PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
S100A8	0	ERG28	0	two hybrid	Stelzl U (2005)	1
FXR1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
PCDHA4	1	ERG28	0	two hybrid	Stelzl U (2005)	1
PAFAH1B3	1	ERG28	0	two hybrid	Stelzl U (2005)	1
HNRNPH3	1	HNRNPUL1	1	biochemical, two hybrid, two hybrid	Havugimana PC (2012), Hegele A (2012), Hegele A (2012)	3
COX17	0	ERG28	0	two hybrid	Stelzl U (2005)	1
SAT1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
HMGB1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
PHYHIP	2	TTR	0	two hybrid	Stelzl U (2005)	1
NDUFA4L2	0	DYNLL1	0	two hybrid	Stelzl U (2005)	1
CREB1	1	ERG28	0	two hybrid	Stelzl U (2005)	1
ANXA1	1	ERG28	0	two hybrid	Vinayagam A (2011)	1
SNRPG	0	ERG28	0	two hybrid	Stelzl U (2005)	1
DYNLL1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
MAPK8IP2	5	ERG28	0	two hybrid	Vinayagam A (2011)	1
PPP1R8	0	ERG28	0	two hybrid	Stelzl U (2005)	1
SULT1E1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
TFG	3	ANXA1	1	affinity chromatography technology	Hein MY (2015)	1
NDUFA4L2	0	ERG28	0	two hybrid	Stelzl U (2005)	1
ALDH2	2	HSPE1	0	two hybrid	Lee KH (2002)	1
CRADD	0	ERG28	0	two hybrid	Stelzl U (2005)	1
BAIAP2	6	CDC42	3	far western blotting, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Soltau M (2002), Krugmann S (2001), Krugmann S (2001), Miki H (2000), Bandyopadhyay S (2010), Govind S (2001), Govind S (2001)	7
POLE2	2	ERG28	0	two hybrid	Stelzl U (2005)	1
AQP2	0	ERG28	0	two hybrid	Trimpert C (2017)	1
CLN8	0	ERG28	0	two hybrid	Passantino R (2013)	1
ZNF24	1	ERG28	0	two hybrid	Stelzl U (2005)	1
CCL18	0	ERG28	0	two hybrid	Stelzl U (2005)	1
CSTF2	2	TFG	3	two hybrid	Rolland T (2014)	1
ANXA7	0	ERG28	0	two hybrid	Vinayagam A (2011)	1
NR1H2	2	ERG28	0	two hybrid	Vinayagam A (2011)	1
ZNF24	1	HMGB1	0	pull down	Miyamoto-Sato E (2010)	1
ENO1	3	LMNA	2	affinity chromatography technology	Castello A (2012)	1
MOV10	6	TK1	0	affinity chromatography technology	Castello A (2012)	1
TK1	0	ERG28	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
CREB3	1	ERG28	0	two hybrid	Yu H (2011)	1
FXR1	0	GSK3B	1	affinity chromatography technology	Qie S (2017)	1
MRPL38	2	ERG28	0	two hybrid	Stelzl U (2005)	1
SERPINB9	0	ERG28	0	two hybrid	Stelzl U (2005)	1
MOV10	6	BID	1	affinity chromatography technology	Castello A (2012)	1
ALDH2	2	ERG28	0	two hybrid	Stelzl U (2005)	1
HYLS1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
MOV10	6	CREB3	1	affinity chromatography technology	Castello A (2012)	1
GSK3B	1	ERG28	0	two hybrid	Vinayagam A (2011)	1
TSC22D1	1	ERG28	0	two hybrid	Vinayagam A (2011)	1
ENO1	3	ERG28	0	affinity chromatography technology	Castello A (2012)	1
PHYHIP	2	ERG28	0	two hybrid	Stelzl U (2005)	1
RAB27A	0	ERG28	0	two hybrid	Stelzl U (2005)	1
POLR2C	0	ERG28	0	two hybrid	Stelzl U (2005)	1
LMNA	2	CREB3	1	two hybrid	Dittmer TA (2014)	1
ZFP64	4	ERG28	0	two hybrid	Stelzl U (2005)	1
MPHOSPH6	1	ERG28	0	two hybrid	Stelzl U (2005)	1
SNRPB	0	LSM2	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
SEPHS1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
GSK3B	1	CREB1	1	enzymatic study	Li B (2003)	1
NSF	3	ERG28	0	two hybrid	Stelzl U (2005)	1
FAS	2	ERG28	0	two hybrid	Stelzl U (2005)	1
MTNR1B	1	ERG28	0	two hybrid	Benleulmi-Chaachoua A (2016)	1
BID	1	ERG28	0	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	ERG28	0	two hybrid	Vinayagam A (2011)	1
SAT1	0	HSPE1	0	two hybrid	Stelzl U (2005)	1
DYNLL1	0	CDK5RAP2	3	affinity chromatography technology	Hein MY (2015)	1
PQBP1	1	ERG28	0	two hybrid	Stelzl U (2005)	1
SNRPG	0	SNRPB	0	affinity chromatography technology	Huttlin EL (2017)	1
TFG	3	ERG28	0	two hybrid	Stelzl U (2005)	1
GSK3B	1	DYNLL1	0	affinity chromatography technology	Varjosalo M (2013)	1
CELF3	2	ERG28	0	two hybrid	Stelzl U (2005)	1
HNRNPH3	1	ERG28	0	two hybrid	Stelzl U (2005)	1
PFN1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
SNRPB	0	ERG28	0	two hybrid	Stelzl U (2005)	1
NAT9	1	ERG28	0	two hybrid	Stelzl U (2005)	1
FAS	2	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
HNRNPH3	1	TTR	0	two hybrid	Stelzl U (2005)	1
SAT1	0	SEPHS1	0	two hybrid	Stelzl U (2005)	1
CCDC106	1	ERG28	0	two hybrid	Stelzl U (2005)	1
MOV10	6	HNRNPH3	1	affinity chromatography technology	Castello A (2012)	1
ENO1	3	ANXA1	1	affinity chromatography technology	Castello A (2012)	1
HSPE1	0	ERG28	0	two hybrid	Stelzl U (2005)	1
ANXA7	0	CELF3	2	two hybrid	Vinayagam A (2011)	1
CDC42	3	ERG28	0	two hybrid	Stelzl U (2005)	1
POLR3F	1	ERG28	0	two hybrid	Stelzl U (2005)	1
GADD45A	1	ERG28	0	two hybrid	Vinayagam A (2011)	1
MOV10	6	ANXA1	1	affinity chromatography technology	Castello A (2012)	1
CSTF2	2	ERG28	0	two hybrid	Stelzl U (2005)	1
HNRNPUL1	1	ERG28	0	two hybrid	Stelzl U (2005)	1
MOV10	6	CSTF2	2	affinity chromatography technology	Castello A (2012)	1
LSM2	0	ERG28	0	two hybrid	Stelzl U (2005)	1
CDK5RAP2	3	ERG28	0	two hybrid	Stelzl U (2005)	1
MOV10	6	ANXA7	0	affinity chromatography technology	Castello A (2012)	1
RPS6KA6	0	PQBP1	1	biochemical	Havugimana PC (2012)	1
MOV10	6	LMNA	2	affinity chromatography technology	Castello A (2012)	1
ENO1	3	HNRNPH3	1	affinity chromatography technology	Castello A (2012)	1
BAIAP2	6	ERG28	0	two hybrid	Stelzl U (2005)	1
KLHL20	2	ERG28	0	two hybrid	Stelzl U (2005)	1
MOV10	6	ERG28	0	affinity chromatography technology	Castello A (2012)	1
MRPS12	0	ERG28	0	two hybrid	Stelzl U (2005)	1
LMNA	2	ERG28	0	two hybrid	Dittmer TA (2014)	1
BTBD2	4	ERG28	0	two hybrid	Stelzl U (2005)	1
PEX2	2	ERG28	0	two hybrid	Stelzl U (2005)	1
GSK3B	1	NAT9	1	two hybrid	Vinayagam A (2011)	1
FAS	2	GADD45A	1	two hybrid	Wang J (2011)	1
TTR	0	ERG28	0	two hybrid	Vinayagam A (2011)	1