PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXW7	2	NFKB1	2	affinity chromatography technology	Fekrmandi F (2015)	1
CDX2	4	HNF1A	0	pull down	Mitchelmore C (2000)	1
NFKB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Deng WG (2003), Deng WG (2003), Furia B (2002), Wang H (2010), Wang H (2010), Sen GS (2011), Hassa PO (2003), Hassa PO (2003), Deng WG (2003)	9
CDX2	4	SMARCD1	5	pull down	Yamamichi N (2009)	1
GSK3B	1	NFKB1	2	enzymatic study	Demarchi F (2001)	1
DNMT3L	2	PAX6	3	pull down, imaging technique, affinity chromatography technology	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	3
GSK3B	1	RELA	1	affinity chromatography technology	Neumann M (2011)	1
CDX2	4	SMARCB1	1	pull down	Yamamichi N (2009)	1
CDX2	4	FBXW7	2	affinity chromatography technology	Kumar Y (2016)	1
CDX2	4	SMARCA4	19	pull down	Yamamichi N (2009)	1
FBXW7	2	RELA	1	affinity chromatography technology	Fekrmandi F (2015)	1
PAX6	3	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	3
FBXW7	2	GSK3B	1	affinity chromatography technology	Kwon YW (2012)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
DNMT3L	2	NFKB1	2	pull down	Pacaud R (2014)	1
SMARCA2	17	EP300	36	affinity chromatography technology	Zhang Y (2010)	1
SMARCA2	17	SMARCD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Pal S (2003), Ito T (2008), Tando T (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
CDX2	4	SMARCA2	17	pull down, affinity chromatography technology	Yamamichi N (2009), Yamamichi N (2009)	2
KDM5B	27	CDX2	4	affinity chromatography technology, affinity chromatography technology	Zhou W (2009), Faber K (2013)	2
SMARCD1	5	SMARCB1	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ito T (2008), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
FOXE1	2	CDX2	4	affinity chromatography technology	Li X (2015)	1
EGLN3	0	CDX2	4	affinity chromatography technology	Rodriguez J (2016)	1
NFKB1	2	CDX2	4	affinity chromatography technology	Mutoh H (2007)	1
EGLN3	0	CDK2	0	affinity chromatography technology	Rodriguez J (2016)	1
FBXW7	2	CDK2	0	affinity chromatography technology, affinity chromatography technology	Zhang W (2012), Zhang W (2012)	2
DNMT3L	2	CDX2	4	pull down	Pacaud R (2014)	1
RELA	1	CDX2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mutoh H (2007), Kim SP (2004), Kim SP (2004)	3
CDX2	4	GSK3B	1	affinity chromatography technology	Kumar Y (2016)	1
PAX6	3	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Yang Y (2006), Yang Y (2006)	2
CDX2	4	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	3
DNMT3L	2	RELA	1	pull down, imaging technique, affinity chromatography technology, pull down	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	4
GSK3B	1	DNMT3L	2	two hybrid	Vinayagam A (2011)	1
CDX2	4	CDK2	0	enzymatic study	Gross I (2005)	1
FOXE1	2	SMARCA4	19	affinity chromatography technology	Li X (2015)	1
PAX6	3	CDX2	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	4
SMARCB1	1	SMARCA4	19	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, genetic interference, affinity chromatography technology, affinity chromatography technology	Sif S (2001), Sullivan EK (2001), Wang W (1996), Wang W (1996), Otsuki T (2001), Zhao K (1998), Reyes JC (1997), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Bultman SJ (2005), Gong F (2008), Medjkane S (2004), Ito T (2008), Sif S (1998), Dallas PB (1998), Tando T (2010), Bakshi R (2010), Bakshi R (2010), Mahmoudi T (2006), Mahmoudi T (2006), Bartlett C (2011), Nishimoto N (2012), Havugimana PC (2012), Wan C (2015), Shen JP (2017), Pchelintsev NA (2013), Pchelintsev NA (2013)	30
SMARCA4	19	SMARCA2	17	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Reyes JC (1997), Pal S (2003), Ito T (2008), Ito T (2008), Havugimana PC (2012)	5
SMARCB1	1	SMARCA2	17	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Sif S (2001), Wang W (1996), Wang W (1996), Pal S (2003), Nakamura T (2002), Ito T (2008), Sif S (1998), Havugimana PC (2012), Wan C (2015)	9
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
SMARCD1	5	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hsiao PW (2003), Pal S (2003), Ito T (2008), Tando T (2010), Mak AB (2010), Oh J (2008), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	10
EP300	36	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Felzien LK (1999), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
EGLN3	0	RELA	1	affinity chromatography technology	Rodriguez J (2016)	1
RELA	1	SMARCA2	17	imaging technique	Ishizaka A (2012)	1
EGLN3	0	GSK3B	1	affinity chromatography technology	Rodriguez J (2016)	1
EP300	36	HNF1A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ban N (2002), Ban N (2002), Dohda T (2004), Dohda T (2004)	4