PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	CSE1L	1	affinity chromatography technology, pull down, affinity chromatography technology	Jiang MC (2002), Uen WC (2010), Uen WC (2010)	3
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
CTNNB1	30	EZR	8	affinity chromatography technology	Hiscox S (1999)	1
HSPA8	4	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Du C (2017), Du C (2017)	3
CDH1	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Schmeiser K (1999), Catimel B (2005), Guo Z (2014)	7
IQGAP1	1	CTNNB1	30	pull down	Briggs MW (2002)	1
EZR	8	IQGAP1	1	pull down	Berryman M (2000)	1
SRC	2	CBLL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swaminathan G (2011), Shen Y (2008), Shrestha H (2017)	3
SRC	2	IQGAP1	1	affinity chromatography technology	Meyer RD (2008)	1
CREBBP	29	NFE2L2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Katoh Y (2001), Katoh Y (2001), Katoh Y (2001), Liu GH (2008), Liu GH (2008), Sun Z (2009), Sun Z (2009), Sun Z (2009)	8
EGFR	5	HSPA5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Yao Z (2017)	4
PSEN1	11	CTNND1	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Tanahashi H (1999), Tanahashi H (1999), Tanahashi H (1999), Shrestha H (2017)	4
FYN	1	CTNND1	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Martinez MC (2003), Piedra J (2003), Piedra J (2003)	3
CFTR	5	VCL	6	affinity chromatography technology	Pankow S (2015)	1
CTNNB1	30	SRC	2	affinity chromatography technology	Xi Y (2013)	1
MAGI1	3	CDH1	4	affinity chromatography technology, bioid	Dobrosotskaya IY (2000), Guo Z (2014)	2
NDRG1	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tu LC (2007), Tu LC (2007), Tu LC (2007)	3
CFTR	5	EZR	8	affinity chromatography technology, affinity chromatography technology	Sun F (2000), Pankow S (2015)	2
MAGI1	3	CTNNB1	30	two hybrid, affinity chromatography technology, pull down	Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000)	3
CDC42	3	CDH1	4	pull down, affinity chromatography technology	Shen Y (2008), Shen Y (2008)	2
EP300	36	KRT18	2	two hybrid	Wang J (2011)	1
KLF4	2	HDAC1	4	pull down	Noti JD (2005)	1
CFTR	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meacham GC (1999), Younger JM (2004), Fuller W (2000), Rubenstein RC (2000), Matsumura Y (2011), Goldstein RF (2007), Goldstein RF (2007), Meacham GC (2001), Meacham GC (2001), Wang X (2006), Matsumura Y (2013), Zaman K (2006), Pankow S (2015)	13
CTNNB1	30	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma H (2005), Sustmann C (2008), Taurin S (2006), Zhao Y (2016), Benoit YD (2017)	5
CDC42	3	MYO6	3	two hybrid	Bandyopadhyay S (2010)	1
PSEN1	11	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tesco G (1998), Kang DE (1999), Murayama M (1998), Prager K (2007), Prager K (2007), Prager K (2007), Serban G (2005), Raurell I (2006), Raurell I (2006)	9
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
EGFR	5	EZR	8	protein complementation assay	Petschnigg J (2014)	1
CDH3	3	CTNNA1	7	biochemical, affinity chromatography technology, affinity chromatography technology	Klingelhoefer J (2000), Klingelhoefer J (2000), Schmeiser K (1999)	3
CDH1	4	VCL	6	affinity chromatography technology, affinity chromatography technology, bioid	Hazan RB (1997), Hazan RB (1998), Guo Z (2014)	3
CDC27	2	CDH1	4	affinity chromatography technology, affinity chromatography technology	Chen M (2012), Tran K (2010)	2
CFTR	5	HSPA5	0	affinity chromatography technology	Pankow S (2015)	1
CTNNB1	30	VCL	6	affinity chromatography technology, affinity chromatography technology	Hazan RB (1997), Chang CC (2012)	2
SKP2	2	NDRG1	2	affinity chromatography technology	Wang Y (2017)	1
CFTR	5	CDH1	4	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
CDH1	4	JUP	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Hazan RB (1998), Shibata T (1994), Hinck L (1994), Knudsen KA (1992), Geng F (2012), Guo Z (2014)	7
HSPA8	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Polanowska-Grabowska R (1997), Cid C (2007)	2
CDC42	3	CBLL1	6	pull down, imaging technique	Shen Y (2008), Shen Y (2008)	2
CDH1	4	CBLL1	6	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Fujita Y (2002), Fujita Y (2002), Hirao T (2006), Swaminathan G (2011), Shen Y (2008), Chen Y (2009), Mukherjee M (2012), Smyth D (2012), Figueiredo J (2013), Shrestha H (2017)	10
EP300	36	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kitagawa M (2008), Inuzuka H (2012), Inuzuka H (2012), Oh M (2016)	4
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
NDRG1	2	HSPA5	0	affinity chromatography technology	Tu LC (2007)	1
CDC27	2	CTNNB1	30	pull down	Gomes NP (2006)	1
CREBBP	29	MDM2	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Inoue Y (2011), Wang X (2004), Sanchez M (2012)	3
CDH1	4	EP300	36	affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005)	2
CDH1	4	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Genda T (2000), Swaminathan G (2011), Shen Y (2008), Guo Z (2014)	4
NFE2L2	1	HDAC2	1	affinity chromatography technology	Lee DY (2012)	1
CTNNB1	30	CTNND1	4	affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Kucerova D (2001)	2
CREBBP	29	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nath S (2011), Nath S (2011), Townsend K (2009)	3
HSPA5	0	IQGAP1	1	biochemical	Havugimana PC (2012)	1
CREBBP	29	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Ito K (2000), Adenuga D (2010)	2
CTNNB1	30	JUP	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hazan RB (1998), Kucerova D (2001), Hein MY (2015), Chen TC (2014)	4
CDH1	4	MET	7	affinity chromatography technology, affinity chromatography technology	Davies G (2001), Davies G (2001)	2
HSPA5	0	CTNNA1	7	affinity chromatography technology	Hein MY (2015)	1
CFTR	5	CTNNA1	7	affinity chromatography technology	Pankow S (2015)	1
EGFR	5	HDAC1	4	affinity chromatography technology	Yao Z (2017)	1
CTNNB1	30	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vietor I (2005), Billin AN (2000), Iguchi H (2007), Iioka H (2009)	4
CTNNA1	7	VCL	6	pull down, affinity chromatography technology	Watabe-Uchida M (1998), Hein MY (2015)	2
EP300	36	SRC	2	affinity chromatography technology, affinity chromatography technology	Paladino D (2016), Paladino D (2016)	2
CDH1	4	KRT18	2	affinity chromatography technology, bioid	Catimel B (2005), Guo Z (2014)	2
CDH1	4	EZR	8	affinity chromatography technology, bioid	Hiscox S (1999), Guo Z (2014)	2
CDH1	4	HSPA8	4	affinity chromatography technology, bioid	Catimel B (2005), Guo Z (2014)	2
CFTR	5	CSE1L	1	affinity chromatography technology	Wang X (2006)	1
HSPA5	0	CSE1L	1	affinity chromatography technology	Hein MY (2015)	1
EP300	36	KLF4	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Evans PM (2007), Yu K (2011), Yu K (2011), Zhang R (2010), Allen KL (2011)	5
SRC	2	MDM2	2	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015)	5
CDH3	3	CTNNB1	30	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klingelhoefer J (2000), Klingelhoefer J (2000), Schmeiser K (1999), Ribeiro AS (2013)	4
EP300	36	JUP	7	affinity chromatography technology	Zhao Y (2016)	1
NFE2L2	1	CDH1	4	affinity chromatography technology, affinity chromatography technology, pull down	Kim WD (2012), Kim WD (2012), Kim WD (2012)	3
CDH1	4	CDH1	4	biochemical, affinity chromatography technology, pull down	Klingelhoefer J (2000), Klingelhoefer J (2000), Pertz O (1999)	3
CREBBP	29	JUP	7	affinity chromatography technology	Zhao Y (2016)	1
PSEN1	11	PKP4	5	affinity chromatography technology, pull down, two hybrid	Stahl B (1999), Stahl B (1999), Stahl B (1999)	3
MDM2	2	CDH1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang JY (2006), Yang JY (2006), Yang JY (2006), Adhikary A (2014)	4
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
PPP1CA	3	CDH1	4	affinity chromatography technology, bioid	Flores-Delgado G (2007), Guo Z (2014)	2
EGFR	5	JUP	7	pull down, affinity chromatography technology, two hybrid, protein complementation assay	Hazan RB (1998), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014)	4
KEAP1	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Huo L (2015), Huo L (2015), Huo L (2015)	3
CDH1	4	HSPA5	0	affinity chromatography technology, bioid	Catimel B (2005), Guo Z (2014)	2
PSEN1	11	CTNNA1	7	affinity chromatography technology	Georgakopoulos A (1999)	1
PPP1CA	3	MDM2	2	affinity chromatography technology	Liu X (2016)	1
MET	7	CTNNB1	30	affinity chromatography technology	Davies G (2001)	1
SKP2	2	CDH1	4	affinity chromatography technology, enzymatic study	Chen JY (2011), Liu YQ (2015)	2
PPP1CA	3	SKP2	2	affinity chromatography technology	Liu X (2016)	1
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
CDH1	4	HDAC2	1	biochemical, affinity chromatography technology, imaging technique	Yoon YM (2004), Yoon YM (2004), Chen TC (2014)	3
CFTR	5	CTNNB1	30	affinity chromatography technology	Pankow S (2015)	1
KLF4	2	HDAC2	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Meng F (2009), Meng F (2009), Noti JD (2005), Yu K (2011), Yu K (2011)	5
CDH3	3	JUP	7	affinity chromatography technology, biochemical	Klingelhoefer J (2000), Klingelhoefer J (2000)	2
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	KRT18	2	affinity chromatography technology	Pankow S (2015)	1
CDH1	4	CTNND1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, bioid	Daniel JM (1995), Daniel JM (1995), Ireton RC (2002), Kinch MS (1995), Hazan RB (1998), Bonne S (2003), Piedra J (2003), Piedra J (2003), Shibamoto S (1995), Shibamoto S (1995), Ohkubo T (1999), Ohkubo T (1999), Ishiyama N (2010), Ishiyama N (2010), Ishiyama N (2010), Chen Y (2009), Smyth D (2012), Del Valle-Perez B (2011), Figueiredo J (2013), Ribeiro AS (2013), Pinheiro H (2012), Guo Z (2014)	22
EP300	36	HSPA5	0	affinity chromatography technology, affinity chromatography technology	Chang YW (2014), Chang YW (2014)	2
IQGAP1	1	PPP1CA	3	affinity chromatography technology	Hein MY (2015)	1
HDAC1	4	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Ito A (2002), Ito A (2002), Gaughan L (2005), Gaughan L (2005)	5
CDH1	4	HDAC1	4	affinity chromatography technology, biochemical	Yoon YM (2004), Yoon YM (2004)	2
CTNND1	4	SRC	2	affinity chromatography technology	Piedra J (2003)	1
KLF4	2	CDH1	4	affinity chromatography technology, affinity chromatography technology	Hu D (2011), Hu D (2011)	2
VCL	6	HSPA5	0	biochemical	Kristensen AR (2012)	1
CTNNB1	30	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Oyama T (1994), Roe S (1998), Piedra J (2003), Aberle H (1994), Reuver SM (1998), Selbach M (2006), Tian Q (2004), Wan C (2015), Hein MY (2015), Ji H (2009), Ji H (2009)	11
SRC	2	MET	7	affinity chromatography technology	Rahimi N (1998)	1
EGFR	5	HSPA8	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Yao Z (2017)	8
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
HDAC1	4	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Guo C (2007), Chen CS (2005)	2
HSPA8	4	CREBBP	29	affinity chromatography technology	Du C (2017)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
CDH1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005)	2
CTNNB1	30	EP300	36	genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, genetic interference, affinity chromatography technology	Kennell JA (2003), Sun Y (2000), Sun Y (2000), Sun Y (2000), Saegusa M (2005), Daniels DL (2002), Levy L (2004), Labalette C (2004), Lee YH (2006), Zhao Y (2016)	10
EGFR	5	CSE1L	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Yao Z (2017)	2
KEAP1	0	NFE2L2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, unspecified method, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cullinan SB (2003), Shibata T (2008), Wang XJ (2008), Nioi P (2007), Tanigawa S (2007), Tanigawa S (2007), Hong F (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2003), McMahon M (2006), Ichikawa T (2009), Niture SK (2009), Niture SK (2009), Wu JH (2010), Wong DP (2010), Wong DP (2010), Yu M (2011), Lau A (2010), Lau A (2010), Kay HY (2010), Sun Z (2011), Sun Z (2011), Li X (2004), Li X (2004), Lo SC (2008), Plafker KS (2010), Plafker KS (2010), Yao JW (2012), Li Y (2012), Lo SC (2006), Lo SC (2006), Lo SC (2006), Eggler AL (2005), Zipper LM (2002), Sekhar KR (2002), Seng S (2009), Hast BE (2013), Hoerer S (2013), Baba K (2013), Wang J (2011), Ichimura Y (2013), Baird L (2013), Baird L (2013), Gorrini C (2013), Schaap M (2013), Jiang ZY (2014), Hast BE (2014), Hast BE (2014), Hast BE (2014), Qin S (2014), Buommino E (2012), Kaspar JW (2012), Kaspar JW (2012), Camp ND (2012), Zhang DD (2004), Furukawa M (2005), Khan H (2015), Huo L (2015), Foygel K (2015), Liu K (2015), Lo SC (2006), Kim WD (2012), Kim WD (2012), Kim WD (2012), Zhang Y (2016), Zhang Y (2016), Wu G (2017), Villeneuve NF (2013), Ma J (2012), Ma J (2012), Ma J (2012), Ge W (2017), Ge W (2017), Yoshizaki Y (2017), Yoshizaki Y (2017), Quinti L (2017), Wang Q (2017), Ha Kim K (2017), Yang C (2016), Mulvaney KM (2016), Lu K (2017)	82
CDH1	4	PIP5K1C	4	fluorescent resonance energy transfe, affinity chromatography technology	Figueiredo J (2013), Geng F (2012)	2
EGFR	5	CTNND1	4	pull down, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Shrestha H (2016)	7
MDM2	2	EZR	8	pull down	Miyamoto-Sato E (2010)	1
CTNND1	4	CDH3	3	affinity chromatography technology, affinity chromatography technology	Reynolds AB (1996), Ribeiro AS (2013)	2
SRC	2	CREBBP	29	pull down, affinity chromatography technology, imaging technique	Whiting RJ (2012), Ruas JL (2005), Ruas JL (2005)	3
RAD17	2	CDH1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2010), Zhang L (2010), Zhang L (2010)	3
FYN	1	CDH1	4	affinity chromatography technology, pull down	Piedra J (2003), Piedra J (2003)	2
CDH1	4	MYO6	3	pull down, bioid	Mangold S (2012), Guo Z (2014)	2
HSPA5	0	HSPA8	4	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
CTNNB1	30	HSPA8	4	affinity chromatography technology	Tian Q (2004)	1
CDH1	4	PSEN1	11	affinity chromatography technology, affinity chromatography technology	Georgakopoulos A (1999), Serban G (2005)	2
CFTR	5	MYO6	3	affinity chromatography technology, affinity chromatography technology	Collaco A (2010), Pankow S (2015)	2
EGFR	5	CTNNB1	30	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Schroeder JA (2002), Takahashi K (1997), Li J (2013)	4
PKP4	5	CDH1	4	two hybrid, bioid	Hatzfeld M (2003), Guo Z (2014)	2
JUP	7	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical, biochemical, imaging technique	Roe S (1998), Roe S (1998), Sacco PA (1995), Obama H (1997), Bandyopadhyay S (2010), Havugimana PC (2012), Wan C (2015), Chen TC (2014)	8
MDM2	2	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Lu TL (2010), Okoro DR (2013)	2
NFE2L2	1	HDAC1	4	affinity chromatography technology	Lee DY (2012)	1
CFTR	5	CDH3	3	affinity chromatography technology	Pankow S (2015)	1
IQGAP1	1	CDH1	4	affinity chromatography technology, pull down, bioid	Li Z (1999), Li Z (1999), Guo Z (2014)	3
EGFR	5	CTNNA1	7	imaging technique, affinity chromatography technology	Chen TC (2014), Li J (2013)	2
NDRG1	2	CDH1	4	affinity chromatography technology, affinity chromatography technology, bioid	Tu LC (2007), Tu LC (2007), Guo Z (2014)	3
CDH3	3	CDH1	4	affinity chromatography technology, affinity chromatography technology, biochemical	Klingelhoefer J (2000), Klingelhoefer J (2000), Klingelhoefer J (2000)	3
CFTR	5	HDAC2	1	affinity chromatography technology	Pankow S (2015)	1
CDC42	3	IQGAP1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuroda S (1996), Kuroda S (1996), Fukata M (2002), Hart MJ (1996), Hart MJ (1996), Joyal JL (1997), Zhang B (1998), Bourguignon LY (2005), Hein MY (2015), Hein MY (2015)	10
KEAP1	0	CDH1	4	affinity chromatography technology, affinity chromatography technology, pull down, bioid	Kim WD (2012), Kim WD (2012), Kim WD (2012), Guo Z (2014)	4
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
EGFR	5	IQGAP1	1	affinity chromatography technology	Casar B (2009)	1
FYN	1	CTNNB1	30	enzymatic study, imaging technique	Piedra J (2003), Chen TC (2014)	2
CREBBP	29	KLF4	2	pull down, affinity chromatography technology, enzymatic study, imaging technique, imaging technique	Geiman DE (2000), Geiman DE (2000), Evans PM (2007), Kalra IS (2011), Allen KL (2011)	5
CTNNA1	7	CTNND1	4	affinity chromatography technology	Daniel JM (1995)	1
EGFR	5	MET	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li J (2013), Li L (2015), Liu X (2011)	3