PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XIAP	0	NEK6	2	two hybrid	Rolland T (2014)	1
PARD6B	0	CDC42	3	pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Joberty G (2000), Joberty G (2000), Joberty G (2000), Noda Y (2001), Noda Y (2001), Bandyopadhyay S (2010), Brajenovic M (2004), Hayase J (2013), Hayase J (2013), Hayase J (2013), Rolland T (2014)	11
TRIP10	1	WASL	2	pull down, biochemical	Tsujita K (2006), Wan C (2015)	2
CDC42	3	RAP1A	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CDC42	3	MAP3K4	1	pull down, imaging technique	Gerwins P (1997), Chen TC (2014)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
XIAP	0	ARHGDIA	3	affinity chromatography technology, affinity chromatography technology	Liu J (2011), Liu J (2012)	2
TRIP10	1	WAS	0	two hybrid, pull down, affinity chromatography technology, two hybrid	Tian L (2000), Tian L (2000), Tian L (2000), Yu H (2011)	4
IQGAP1	1	WASL	2	affinity chromatography technology	Carmon KS (2014)	1
TNK2	7	NEK6	2	two hybrid	Rolland T (2014)	1
CDC42	3	CDH1	4	pull down, affinity chromatography technology	Shen Y (2008), Shen Y (2008)	2
BAIAP2	6	WASL	2	two hybrid, affinity chromatography technology	Wang J (2011), Hein MY (2015)	2
PAK2	0	GDI1	1	biochemical	Wan C (2015)	1
PAK3	2	ARHGEF7	3	two hybrid	Bagrodia S (1998)	1
ARHGEF6	0	PAK2	0	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
ARHGEF7	3	CBL	7	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Flanders JA (2003), Flanders JA (2003), Schmidt MH (2006), Schmidt MH (2006), Schmidt MH (2006), Wu WJ (2003), Singh VK (2012), Singh VK (2012), Chang CC (2012)	9
CDH1	4	BAIAP2	6	bioid	Guo Z (2014)	1
CDC42	3	CBLL1	6	pull down, imaging technique	Shen Y (2008), Shen Y (2008)	2
NEK6	2	PAK6	0	two hybrid	Wang J (2011)	1
CDC42	3	CDC42EP2	0	pull down, pull down, two hybrid, two hybrid, two hybrid, two hybrid	Hirsch DS (2001), Joberty G (1999), Joberty G (1999), Bandyopadhyay S (2010), Wang J (2011), Rolland T (2014)	6
BAIAP2	6	CDC42	3	far western blotting, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Soltau M (2002), Krugmann S (2001), Krugmann S (2001), Miki H (2000), Bandyopadhyay S (2010), Govind S (2001), Govind S (2001)	7
CDH1	4	CBLL1	6	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Fujita Y (2002), Fujita Y (2002), Hirao T (2006), Swaminathan G (2011), Shen Y (2008), Chen Y (2009), Mukherjee M (2012), Smyth D (2012), Figueiredo J (2013), Shrestha H (2017)	10
CDH1	4	PAK6	0	bioid	Guo Z (2014)	1
PARD6G	0	PARD6B	0	affinity chromatography technology	Brajenovic M (2004)	1
CDC42	3	ARHGAP1	0	two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Nagata K (1998), Li R (1997), Low BC (1999), Zhang B (1998), Owen D (2000), Jaffe AB (2004), Jaffe AB (2004)	7
PARD6A	0	CDC42	3	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Joberty G (2000), Qiu RG (2000), Qiu RG (2000), Noda Y (2001), Noda Y (2001), Brajenovic M (2004)	6
CDC42	3	PLD1	5	pull down, affinity chromatography technology	Walker SJ (2000), Walker SJ (2000)	2
ARHGDIG	1	CDC42	3	pull down, biochemical	Adra CN (1997), Wan C (2015)	2
GDI1	1	CDC42	3	pull down, affinity chromatography technology	Gibson RM (2001), Gibson RM (2001)	2
CDC42	3	PAK3	2	two hybrid, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Wang JB (2005), Govind S (2001)	3
CDC42	3	ARHGEF6	0	affinity chromatography technology, imaging technique	Feng Q (2004), Chen TC (2014)	2
CDC42	3	ERRFI1	1	affinity chromatography technology, pull down	Makkinje A (2000), Makkinje A (2000)	2
PAK1	2	PAK2	0	affinity chromatography technology	Varjosalo M (2013)	1
ITSN1	5	CDC42	3	affinity chromatography technology, pull down, x-ray crystallography	Hussain NK (2001), Hussain NK (2001), Snyder JT (2002)	3
AGAP2	14	CDC42	3	two hybrid, pull down	Luo R (2012), Luo R (2012)	2
PAK1	2	CDC42	3	pull down, pull down, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Seoh ML (2003), Zhang B (1998), Bandyopadhyay S (2010), Mott HR (1999), Owen D (2000), Morreale A (2000), Wells CD (2006), Marivin A (2013), Varjosalo M (2013), Shen Y (2008), Gonzalez-Martinez D (2004)	11
PAK2	0	ARHGEF7	3	pull down, affinity chromatography technology	Kaerkkaeinen S (2006), Hein MY (2015)	2
PAK4	3	PAK6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARHGEF7	3	LRRK2	5	affinity chromatography technology, imaging technique, enzymatic study	Haebig K (2010), Haebig K (2010), Haebig K (2010)	3
CDH1	4	ARHGAP32	11	bioid	Guo Z (2014)	1
CDC42	3	BIRC2	1	pull down, pull down, affinity chromatography technology, enzymatic study	Marivin A (2013), Marivin A (2013), Marivin A (2013), Murali A (2017)	4
PAK4	3	PAK5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC42	3	CBL	7	affinity chromatography technology, pull down, affinity chromatography technology	Wu WJ (2003), Wu WJ (2003), Simmons A (2005)	3
ARHGEF6	0	PAK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013), Huttlin EL (2017)	3
ITSN1	5	WASL	2	pull down	Hussain NK (2001)	1
RAP1A	1	ARHGDIA	3	biochemical	Wan C (2015)	1
CDC42	3	CDC42SE2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Pirone DM (2000), Hein MY (2015), Huttlin EL (2017)	3
WASL	2	CDC42	3	pull down, pull down, two hybrid, pull down	Carlier MF (2000), Miki H (1998), Bandyopadhyay S (2010), Martinez-Quiles N (2001)	4
BNIP2	0	CDC42	3	pull down, enzymatic study, affinity chromatography technology, two hybrid, pull down	Low BC (2000), Low BC (2000), Low BC (2000), Low BC (2000), Low BC (1999)	5
WAS	0	TNK2	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yokoyama N (2005), Yokoyama N (2005), Yokoyama N (2005)	3
CBL	7	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
PAK5	0	CDC42	3	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Dan C (2002), Pandey A (2002), Pandey A (2002), Bandyopadhyay S (2010)	4
PAK4	3	CDC42	3	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical, affinity chromatography technology	Ewing RM (2007), Dan C (2002), Abo A (1998), Bandyopadhyay S (2010), Wan C (2015), Dart AE (2015)	6
PAK2	0	CDC42	3	unspecified method, pull down, pull down, two hybrid, pull down, two hybrid	Stevens WK (1999), Abo A (1998), Zhang B (1998), Bandyopadhyay S (2010), Kaerkkaeinen S (2010), Rolland T (2014)	6
CDC42	3	IQGAP2	6	pull down, affinity chromatography technology	Brill S (1996), Brill S (1996)	2
ITSN1	5	WAS	0	affinity chromatography technology, affinity chromatography technology	Tsyba L (2008), Wang JB (2005)	2
PAK3	2	ITSN1	5	affinity chromatography technology	Wang JB (2005)	1
CDC42	3	TRAF2	1	affinity chromatography technology, pull down	Marivin A (2013), Marivin A (2013)	2
ARHGAP32	11	CDC42	3	enzymatic study, enzymatic study, enzymatic study, two hybrid	Nakazawa T (2003), Zhao C (2003), Nakamura T (2002), Bandyopadhyay S (2010)	4
LRRK2	5	TRAF2	1	enzymatic study	Zach S (2010)	1
TNK2	7	CDC42	3	affinity chromatography technology, two hybrid, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Kato-Stankiewicz J (2001), Bandyopadhyay S (2010), Lin Q (2010), Mott HR (1999), Mott HR (1999), Gu Y (2004), Gu Y (2004), Owen D (2000), Govind S (2001), Jones S (2014), Jones S (2014), Urena JM (2005), Urena JM (2005), Tetley GJN (2017), Tetley GJN (2017)	15
NEK6	2	CDC42	3	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
PARD6B	0	PARD6A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Hein MY (2015)	3
ARHGDIA	3	CDC42	3	affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Ewing RM (2007), Gorvel JP (1998), Bandyopadhyay S (2010), Vinayagam A (2011), Marivin A (2013), Marivin A (2013), Wan C (2015)	7
CBL	7	MAP3K11	7	affinity chromatography technology	Sproul AA (2009)	1
PARD6G	0	CDC42	3	pull down, affinity chromatography technology	Noda Y (2001), Brajenovic M (2004)	2
IQGAP1	1	RAP1A	1	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	PAK2	0	bioid	Guo Z (2014)	1
ARHGEF6	0	CBL	7	affinity chromatography technology, affinity chromatography technology	Kortuem F (2015), Kortuem F (2015)	2
TRIP10	1	CDC42	3	two hybrid, pull down, pull down	Aspenstroem P (1997), Tian L (2000), Aspenstroem P (1997)	3
CDC42	3	CDC42EP1	1	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Bandyopadhyay S (2010), Wang J (2011), Rolland T (2014)	4
CBL	7	ITSN1	5	far western blotting, two hybrid, affinity chromatography technology, affinity chromatography technology	Martin NP (2006), Thalappilly S (2008), Dergai M (2011), Tsyba L (2008)	4
ARHGDIA	3	GDI1	1	biochemical	Wan C (2015)	1
CDC42	3	CDC42EP5	0	pull down, two hybrid, pull down	Hirsch DS (2001), Joberty G (1999), Joberty G (1999)	3
CDC42	3	ARHGEF7	3	affinity chromatography technology, pull down	Wu WJ (2003), Wu WJ (2003)	2
CDC42	3	WAS	0	pull down, pull down, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down	Tian L (2000), Kim AS (2000), Kolluri R (1996), Symons M (1996), Bandyopadhyay S (2010), Mott HR (1999), Owen D (2000), Edlund S (2004), Tetley GJN (2017)	9
CDC42	3	XIAP	0	affinity chromatography technology, pull down, enzymatic study, pull down	Murali A (2017), Murali A (2017), Murali A (2017), Murali A (2017)	4
CBL	7	IQGAP1	1	affinity chromatography technology	Brehme M (2009)	1
CDC42	3	LRRK2	5	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Haebig K (2010), Haebig K (2010), Haebig K (2010), Chan D (2011)	4
CDH1	4	CBL	7	bioid	Guo Z (2014)	1
BAIAP2	6	PAK1	2	pull down	Miki H (2000)	1
MCF2L	4	CDC42	3	affinity chromatography technology, x-ray crystallography, pull down	Cheng L (2004), Rossman KL (2002), Rossman KL (2002)	3
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
LRRK2	5	IQGAP1	1	affinity chromatography technology	Liu Z (2011)	1
CDC42	3	CDC42SE1	0	two hybrid, two hybrid, affinity chromatography technology	Pirone DM (2000), Bandyopadhyay S (2010), Huttlin EL (2017)	3
CDC42	3	MAP3K11	7	two hybrid, affinity chromatography technology, imaging technique	Nagata K (1998), Boeck BC (2000), Chen TC (2014)	3
CDC42	3	PAK6	0	pull down, two hybrid	Lee SR (2002), Bandyopadhyay S (2010)	2
ARHGEF6	0	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology	Feng Q (2004), Huttlin EL (2017)	2
PAK1	2	ARHGEF7	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Ku GM (2001), Schmidt MH (2006), Bandyopadhyay S (2010), Varjosalo M (2013), Huttlin EL (2017)	5
IQGAP1	1	CDH1	4	affinity chromatography technology, pull down, bioid	Li Z (1999), Li Z (1999), Guo Z (2014)	3
CDC42	3	CDC42EP3	1	two hybrid, pull down, two hybrid, two hybrid	Alberts AS (1998), Joberty G (1999), Joberty G (1999), Bandyopadhyay S (2010)	4
WAS	0	CBL	7	affinity chromatography technology	Watanabe Y (2013)	1
CDH1	4	CDC42EP1	1	bioid	Guo Z (2014)	1
BNIP2	0	ARHGAP1	0	pull down, pull down, two hybrid, affinity chromatography technology, pull down	Low BC (2000), Low BC (2000), Low BC (2000), Low BC (1999), Low BC (1999)	5
CDC42	3	MAP3K10	2	two hybrid, pull down	Nagata K (1998), Nagata K (1998)	2
TRAF2	1	MAP3K11	7	affinity chromatography technology	Korchnak AC (2009)	1
CDH1	4	ARHGAP1	0	bioid	Guo Z (2014)	1
CDC42	3	IQGAP1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuroda S (1996), Kuroda S (1996), Fukata M (2002), Hart MJ (1996), Hart MJ (1996), Joyal JL (1997), Zhang B (1998), Bourguignon LY (2005), Hein MY (2015), Hein MY (2015)	10
CDH1	4	PAK4	3	bioid	Guo Z (2014)	1