PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NR1H4	0	XRCC6	3	affinity chromatography technology, pull down, affinity chromatography technology	Ohno M (2009), Ohno M (2009), Ohno M (2009)	3
NR1H4	0	RXRA	1	two hybrid, pull down, pull down, affinity chromatography technology	Seol W (1995), Seol W (1995), Kemper JK (2009), Kemper JK (2009)	4
NCOA6	6	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Ko L (2000), Ko L (2003)	2
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
NCOR2	12	SUMO1	0	enzymatic study	Jiang J (2010)	1
NCOA6	6	NCOR2	12	two hybrid	Lee SK (2001)	1
SIRT1	3	NCOR1	9	pull down, affinity chromatography technology	Hisahara S (2008), Hisahara S (2008)	2
NR1H4	0	GAPDH	0	two hybrid	Albers M (2005)	1
SMARCD1	5	NR1H4	0	pull down	Hsiao PW (2003)	1
GAPDH	0	EP300	36	affinity chromatography technology, affinity chromatography technology	Sen N (2008), Sen N (2008)	2
ESR1	0	GAPDH	0	affinity chromatography technology	Tarallo R (2011)	1
EP300	36	ESR1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Fajas L (2002), Fan S (2002), Fan S (2002), Fan S (2002), Kang YK (2002), Kang YK (2002), Hao L (2010), Jin W (2008), Cui Y (2006), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Kim SH (2010), Ma Y (2010), Ma Y (2010), Fujita T (2003), Likhite VS (2004), Band AM (2011), Loven MA (2004), Nalvarte I (2010), Yi P (2015)	21
PPARGC1A	3	SIRT1	3	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	Amat R (2009), Nemoto S (2005), Nemoto S (2005), Nemoto S (2005)	4
NCOR2	12	GPS2	0	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi J (2011), Oberoi J (2011), Bi H (2014), Huttlin EL (2015), Huttlin EL (2017)	5
EP300	36	RXRA	1	affinity chromatography technology, affinity chromatography technology	Zhao WX (2007), Zhao WX (2007)	2
ESR1	0	PRKDC	12	affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Tarallo R (2011)	2
NCOR1	9	GPS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Zhang J (2002), Zhang J (2002), Zhang J (2002), Zhang J (2002), Zhang J (2002), Huttlin EL (2015), Huttlin EL (2017)	9
NCOA6	6	PRKDC	12	affinity chromatography technology, enzymatic study	Ko L (2000), Ko L (2000)	2
RXRG	1	RXRA	1	affinity chromatography technology	Huttlin EL (2017)	1
PRMT1	3	SIRT1	3	affinity chromatography technology, enzymatic study	Lai Y (2017), Lai Y (2017)	2
SIRT1	3	HIST1H3A	3	enzymatic study	Das C (2009)	1
CARM1	0	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Naeem H (2007), Daujat S (2002), Ananthanarayanan M (2004), Wu J (2012), Yi P (2017)	5
XRCC6	3	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subramanian C (2011), Chaudhary N (2014), Chaudhary N (2014)	3
NCOA1	6	PPARGC1A	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Puigserver P (1999), Puigserver P (1999), Puigserver P (1999), Puigserver P (1999)	4
PRKDC	12	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, affinity chromatography technology	Shao RG (1999), Drouet J (2005), Gottlieb TM (1993), Shamanna RA (2011), Shamanna RA (2011), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Hein MY (2015)	9
ESR1	0	NCOA1	6	pull down, pull down, pull down, pull down, two hybrid, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	DiRenzo J (2000), Sheppard HM (2001), Kalkhoven E (1998), Kang YK (2002), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Tremblay A (2001), Llopis J (2000), Chien PY (1999), Webb P (1998), Webb P (1998), Lazennec G (1997), Heery DM (1997), Heery DM (1997), Torchia J (1997), Torchia J (1997), Fleming FJ (2004), Fujita T (2003), Fujita T (2003), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Kraichely DM (2000), Kraichely DM (2000), Gong EY (2010), Eng FC (1998), Needham M (2000), Needham M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Albers M (2005), Kurtev V (2004), DiRenzo J (1997), Han SJ (2016), Han SJ (2016)	37
CARM1	0	ESR1	0	affinity chromatography technology	Yi P (2017)	1
HIST1H3A	3	NCOR1	9	pull down	Yu J (2003)	1
NCOA6	6	XRCC6	3	affinity chromatography technology, affinity chromatography technology, pull down	Ko L (2000), Ko L (2003), Ko L (2003)	3
RXRA	1	PPARGC1A	3	affinity chromatography technology, pull down, two hybrid, two hybrid	Delerive P (2002), Delerive P (2002), Delerive P (2002), Delerive P (2002)	4
EP300	36	HDAC6	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Han Y (2009), Han Y (2009), Liu Y (2012), Kirilyuk A (2012), Girdwood D (2003)	5
PRMT1	3	CARM1	0	genetic interference	Koh SS (2001)	1
EP300	36	PRKDC	12	pull down	Karmakar S (2010)	1
NCOR1	9	EP300	36	affinity chromatography technology	Cowger JJ (2006)	1
ESR1	0	XRCC6	3	affinity chromatography technology	Ju BG (2006)	1
SMARCD1	5	SMARCD3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR1H4	0	PRKDC	12	affinity chromatography technology, pull down, affinity chromatography technology	Ohno M (2009), Ohno M (2009), Ohno M (2009)	3
NR1H4	0	NCOR2	12	pull down	Johnson DR (2006)	1
PRKDC	12	RRM2	2	genetic interference	Shen JP (2017)	1
XRCC5	5	PRKDC	12	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology	Jin S (1997), Matheos D (2002), Gell D (1999), Drouet J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Olsen BB (2012), Olsen BB (2012), Sand-Dejmek J (2011), Sartorius CA (2000), Sartorius CA (2000), Drouet J (2006), Drouet J (2006), Sibanda BL (2010), Wan C (2015), Hein MY (2015)	17
NR1H4	0	RXRG	1	two hybrid	Albers M (2005)	1
ESR1	0	XRCC5	5	affinity chromatography technology	Ju BG (2006)	1
NCOR2	12	RXRA	1	two hybrid, pull down, two hybrid, two hybrid	Tagami T (1998), Mouchon A (1999), Li H (1997), Albers M (2005)	4
SMARCD3	0	RXRA	1	pull down	Flajollet S (2007)	1
NCOR1	9	ESR1	0	pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique	Huang HJ (2002), Ku TK (2007), Fujita T (2003), Fujita T (2003), Zhu P (2006), Yoshimaru T (2013)	6
NCOR2	12	EP300	36	affinity chromatography technology	Cowger JJ (2006)	1
NR1H4	0	RXRB	0	affinity chromatography technology	Huttlin EL (2017)	1
SMARCD3	0	ESR1	0	pull down	Flajollet S (2007)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
CARM1	0	NCOA1	6	pull down, enzymatic study	Fauquier L (2008), Feng Q (2006)	2
NCOR1	9	SMARCD1	5	biochemical	Havugimana PC (2012)	1
NR1H4	0	NCOA1	6	two hybrid, pull down	Bramlett KS (2000), Cai SY (2010)	2
SMARCD3	0	NR1H4	0	pull down	Debril MB (2004)	1
NR1H4	0	ESR1	0	affinity chromatography technology	Journe F (2008)	1
HDAC6	0	NR1H4	0	affinity chromatography technology	New M (2013)	1
HDAC6	0	GAPDH	0	affinity chromatography technology	Watson GW (2016)	1
HDAC6	0	XRCC5	5	affinity chromatography technology	New M (2013)	1
HIST1H3A	3	HDAC6	0	pull down	Li X (2014)	1
SIRT1	3	NR1H4	0	pull down, enzymatic study	Kemper JK (2009), Kemper JK (2009)	2
EP300	36	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Liu B (2009), Brackertz M (2006), Faiola F (2005), Daujat S (2002), Kalkhoven E (2002), Seo SB (2002), Kim JH (2005), Bordoli L (2001), Kim MY (2001), Kutney SN (2004), Wang F (2010), Loven MA (2004), Kiernan RE (1999), Wong K (2005), Ogryzko VV (1996), Yamaguchi Y (2004), Furumatsu T (2005), An W (2002), Delvecchio M (2013), Delvecchio M (2013), Tropberger P (2013), Das C (2009), Shimura M (2011), Ji A (2003), Fu M (2005), Suganuma T (2002), Tang Z (2013), Kim JH (2006), Lopes da Rosa J (2013), Li X (2014), Wang YL (2008), Du C (2017), Yi P (2017), Wan W (2017)	34
PPARGC1A	3	EP300	36	affinity chromatography technology	Cooper MP (2006)	1
NR1H4	0	PRMT1	3	affinity chromatography technology	Rizzo G (2005)	1
NCOA6	6	PPARGC1A	3	pull down	Surapureddi S (2008)	1
NCOA6	6	RXRA	1	pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down	Lee SK (1999), Lee SK (1999), Lee SK (2001), Kong HJ (2003), Kong HJ (2003), Ko L (2002), Mahajan MA (2000), Mahajan MA (2000), Caira F (2000)	9
NCOR1	9	RXRA	1	pull down, pull down, pull down	Sun Y (2004), Herdick M (2000), Krogsdam AM (2002)	3
PRKDC	12	HIST1H3A	3	imaging technique	Olsen BB (2012)	1
NR1H4	0	SUMO1	0	affinity chromatography technology, affinity chromatography technology	Balasubramaniyan N (2013), Balasubramaniyan N (2013)	2
PRMT1	3	HIST1H3A	3	enzymatic study	Wu J (2012)	1
GPS2	0	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down	Peng YC (2000), Peng YC (2000), Peng YC (2000)	3
EP300	36	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Bouras T (2005), Bourguignon LY (2009)	2
NCOR1	9	NR1H4	0	affinity chromatography technology	Li CW (2009)	1
EP300	36	XRCC6	3	enzymatic study	Cohen HY (2004)	1
CARM1	0	SMARCD1	5	biochemical, affinity chromatography technology	Xu W (2004), Xu W (2004)	2
NCOR1	9	NCOA1	6	pull down	Stevens A (2003)	1
PPARGC1A	3	ESR1	0	pull down	Tcherepanova I (2000)	1
XRCC5	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Zhang Z (2017), Zhang Z (2017)	2
NCOA6	6	EP300	36	affinity chromatography technology, pull down	Ko L (2000), Ko L (2000)	2
PRMT1	3	ESR1	0	pull down	Koh SS (2001)	1
NCOA6	6	NCOA1	6	pull down, pull down, two hybrid, affinity chromatography technology	Surapureddi S (2011), Lee SK (1999), Lee SK (1999), Goo YH (2003)	4
RXRB	0	NCOA1	6	two hybrid	Albers M (2005)	1
SIRT1	3	ESR1	0	affinity chromatography technology	Elangovan S (2011)	1
NCOR2	12	RXRG	1	two hybrid	Albers M (2005)	1
NR1H4	0	HIST1H3A	3	enzymatic study	Ananthanarayanan M (2004)	1
EP300	36	NR1H4	0	enzymatic study	Kemper JK (2009)	1
SIRT1	3	GAPDH	0	affinity chromatography technology, pull down	Kornberg MD (2010), Kornberg MD (2010)	2
RRM2	2	NR1H4	0	affinity chromatography technology	DAngiolella V (2012)	1
NR1H4	0	XRCC5	5	affinity chromatography technology, pull down, affinity chromatography technology	Ohno M (2009), Ohno M (2009), Ohno M (2009)	3
CARM1	0	EP300	36	enzymatic study, pull down, pull down, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Feng Q (2006), Lee YH (2002), Xu W (2001), Xu W (2001), Xu W (2001), Xu W (2001), Lee YH (2005), Hassa PO (2008), Hassa PO (2008), Wang J (2011), Yi P (2017), Yi P (2017), Yi P (2017)	13
HIST1H3A	3	XRCC6	3	affinity chromatography technology, bioid	Fnu S (2011), Lambert JP (2015)	2
SMARCD1	5	ESR1	0	pull down	Hsiao PW (2003)	1
CASP8	1	NR1H4	0	pull down	Stegh AH (2002)	1
EP300	36	PRMT1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Hassa PO (2008), Lai Y (2017), Lai Y (2017)	3
CARM1	0	NR1H4	0	affinity chromatography technology	Ananthanarayanan M (2004)	1
NCOR2	12	NCOR1	9	biochemical, two hybrid	Li J (2000), Korutla L (2005)	2
NCOA6	6	NR1H4	0	pull down	Ananthanarayanan M (2011)	1
ESR1	0	NCOR2	12	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Smith CL (1997), Fleming FJ (2004), Karmakar S (2010), Karmakar S (2010), Fujita T (2003), Fujita T (2003)	6
NCOA1	6	EP300	36	affinity chromatography technology, imaging technique, pull down, pull down	Matsuda S (2004), Wang F (2010), Kino T (2002), Nasrin N (2000)	4
NCOA6	6	ESR1	0	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology	Lee SK (1999), Lee SK (1999), Ko L (2002), Ko L (2002), Ju BG (2006), Mahajan MA (2000), Mahajan MA (2000), Caira F (2000), Han SJ (2016)	9
PRMT1	3	NCOA1	6	pull down	Koh SS (2001)	1
PPARGC1A	3	NR1H4	0	pull down, affinity chromatography technology	Zhang Y (2004), Zhang Y (2004)	2
GPS2	0	NR1H4	0	affinity chromatography technology	Sanyal S (2007)	1