PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PPARGC1A	3	MED1	4	affinity chromatography technology, pull down, pull down	Wallberg AE (2003), Wallberg AE (2003), Wallberg AE (2003)	3
PPARGC1A	3	MED17	0	affinity chromatography technology, pull down	Wallberg AE (2003), Wallberg AE (2003)	2
MED14	0	MED17	0	affinity chromatography technology, biochemical, biochemical	Ryu S (1999), Havugimana PC (2012), Wan C (2015)	3
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
MED12	11	MED24	4	affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Hein MY (2015)	3
NR1I3	2	UBB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED1	4	MED24	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, genetic interference	Yuan CX (1998), Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Horlbeck MA (2018)	8
MED1	4	MED23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, genetic interference	Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Lambert JP (2015), Huttlin EL (2017), Horlbeck MA (2018)	6
MED15	6	MED24	4	biochemical	Wan C (2015)	1
NCOA3	3	PSMC5	4	affinity chromatography technology, imaging technique	Ferry C (2009), Ferry C (2009)	2
MED14	0	MED4	2	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
HNF4A	2	PPARGC1A	3	pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology	Surapureddi S (2008), Bhalla S (2004), Bhalla S (2004), Ponugoti B (2007), Inoue S (2011), Felder TK (2011), Zhang Z (2012), Li T (2005), Li T (2005)	9
POU1F1	2	MED1	4	pull down, affinity chromatography technology	Gordon DF (2006), Gordon DF (2006)	2
MED15	6	MED13	11	affinity chromatography technology	Mittler G (2003)	1
MED14	0	MED24	4	affinity chromatography technology, biochemical, biochemical, genetic interference	Ryu S (1999), Havugimana PC (2012), Wan C (2015), Horlbeck MA (2018)	4
PPARGC1A	3	NR1I3	2	affinity chromatography technology, affinity chromatography technology	Gao J (2015), Gao J (2015)	2
NCOA1	6	NCOA2	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Wu RC (2002), Lodrini M (2008), McKenna NJ (1998), Eng FC (1998)	4
MED17	0	MED24	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NR1I3	2	MAP4	8	two hybrid	Albers M (2005)	1
NR1I3	2	PPM1B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR1I3	2	CHD9	5	pull down	Surapureddi S (2006)	1
NR1I3	2	FTH1	0	two hybrid	Albers M (2005)	1
HNF4A	2	NCOA2	2	two hybrid	Wang JC (1998)	1
HSP90AA1	7	NR1I3	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Chen T (2013)	2
NCOA1	6	PPARGC1A	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Puigserver P (1999), Puigserver P (1999), Puigserver P (1999), Puigserver P (1999)	4
RXRA	1	PSMC5	4	pull down, two hybrid	vom Baur E (1996), Choi HS (1996)	2
MED15	6	MED14	0	affinity chromatography technology, biochemical	Mittler G (2003), Wan C (2015)	2
DNMT3L	2	NR1I3	2	pull down	Pacaud R (2014)	1
RXRA	1	PPARGC1A	3	affinity chromatography technology, pull down, two hybrid, two hybrid	Delerive P (2002), Delerive P (2002), Delerive P (2002), Delerive P (2002)	4
NCOA1	6	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Lodrini M (2008), Lodrini M (2008)	2
MED23	3	MED17	0	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
MED1	4	MED15	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Mittler G (2003), Wan C (2015), Huttlin EL (2017)	6
NR1I3	2	MED17	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR1I3	2	MED23	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PML	7	NCOA2	2	pull down	Liu ST (2013)	1
MED1	4	MED14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, genetic interference	Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Ryu S (1999), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Horlbeck MA (2018)	8
POU1F1	2	NR1I3	2	pull down	Gonzalez MM (2002)	1
NR1I3	2	MED24	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED12	11	MED15	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Mittler G (2003), Hein MY (2015)	3
HNF4A	2	NCOA1	6	two hybrid	Wang JC (1998)	1
NR1I3	2	MED4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNF4A	2	MED14	0	affinity chromatography technology, pull down	Maeda Y (2002), Malik S (2002)	2
NCOA3	3	NCOA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu RC (2002), Lodrini M (2008), Lodrini M (2008)	3
NR1I3	2	NCOA1	6	affinity chromatography technology, two hybrid, affinity chromatography technology	Huttlin EL (2015), Albers M (2005), Huttlin EL (2017)	3
MED23	3	MED4	2	bioid, affinity chromatography technology, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015), Lambert JP (2015)	3
NR1I3	2	SNX13	3	two hybrid	Wang J (2011)	1
MED1	4	MED4	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015), Huttlin EL (2017)	7
NR1I3	2	NR0B1	2	pull down, affinity chromatography technology	Laurenzana EM (2012), Laurenzana EM (2012)	2
NR1I3	2	SRC	2	two hybrid	Laurenzana EM (2012)	1
SRC	2	RXRA	1	pull down	Sun Y (2004)	1
RXRA	1	CHD9	5	affinity chromatography technology	Surapureddi S (2006)	1
MED12	11	MED13	11	affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Wan C (2015), Hein MY (2015)	3
NR1I3	2	SNRPD3	0	two hybrid	Wang J (2011)	1
MED12	11	MED17	0	affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Wan C (2015), Hein MY (2015)	3
RXRA	1	NCOA2	2	pull down, pull down, pull down, pull down	Lee WY (2002), Zhang C (2001), Kindle KB (2005), Voegel JJ (1998)	4
MED12	11	MED4	2	affinity chromatography technology, biochemical, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015), Hein MY (2015)	6
NR1I3	2	PSMC4	6	two hybrid	Choi HS (1996)	1
PML	7	NR1I3	2	affinity chromatography technology, affinity chromatography technology	Gao J (2015), Gao J (2015)	2
NCOA3	3	RXRA	1	pull down, pull down, imaging technique, pull down, pull down	Chen H (1997), Lee WY (2002), Sinkkonen L (2005), Yang W (2000), Takeshita A (1997)	5
PPARGC1A	3	MED14	0	affinity chromatography technology, pull down	Wallberg AE (2003), Wallberg AE (2003)	2
MED4	2	MED17	0	biochemical, bioid, affinity chromatography technology	Wan C (2015), Lambert JP (2015), Lambert JP (2015)	3
MED13	11	MED14	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MED1	4	MED17	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Liu X (2008), Malovannaya A (2010), Donner AJ (2010), Wan C (2015), Huttlin EL (2017)	7
MED14	0	MED23	3	affinity chromatography technology, biochemical, bioid, affinity chromatography technology	Ryu S (1999), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
HNF4A	2	NR1I3	2	pull down	Surapureddi S (2008)	1
MED1	4	MED12	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Malovannaya A (2010), Donner AJ (2010), Davis MA (2013), Tsai KL (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	10
MED24	4	RXRA	1	pull down	Yuan CX (1998)	1
MED17	0	MED13	11	biochemical	Wan C (2015)	1
NR1I3	2	MED13	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR1I3	2	NCOA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PML	7	RXRA	1	pull down, imaging technique	Zhong S (1999), Bellodi C (2006)	2
NR1I3	2	MED1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED15	6	MED17	0	affinity chromatography technology, biochemical	Mittler G (2003), Wan C (2015)	2
NR1I3	2	MED12	11	affinity chromatography technology	Huttlin EL (2015)	1
HNF4A	2	MED23	3	affinity chromatography technology	Maeda Y (2002)	1
MED23	3	MED13	11	bioid	Lambert JP (2015)	1
MED4	2	MED13	11	two hybrid, biochemical, bioid, affinity chromatography technology	Nakayama M (2002), Havugimana PC (2012), Lambert JP (2015), Lambert JP (2015)	4
MED23	3	MED24	4	biochemical, bioid, affinity chromatography technology	Wan C (2015), Lambert JP (2015), Lambert JP (2015)	3
NR1I3	2	PSMC5	4	two hybrid, two hybrid	Choi HS (1996), Albers M (2005)	2
PPARGC1A	3	PML	7	affinity chromatography technology, affinity chromatography technology	Gao J (2015), Gao J (2015)	2
HNF4A	2	MED24	4	pull down	Malik S (2002)	1
MED24	4	MED4	2	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
RXRA	1	NR1I3	2	pull down, pull down, pull down, imaging technique, pull down	Baes M (1994), Goodwin B (2002), Yoshinari K (2010), Yoshinari K (2010), Molnar F (2005)	5
MED15	6	MED23	3	affinity chromatography technology, bioid	Mittler G (2003), Lambert JP (2015)	2
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
MED15	6	MED4	2	biochemical, affinity chromatography technology	Wan C (2015), Lambert JP (2015)	2
MED12	11	MED23	3	affinity chromatography technology, bioid, affinity chromatography technology	Malovannaya A (2010), Lambert JP (2015), Hein MY (2015)	3
MED1	4	MED13	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Davis MA (2013), Tsai KL (2013), Wan C (2015), Huttlin EL (2017)	8
NR1I3	2	MED14	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNF4A	2	MED17	0	pull down	Malik S (2002)	1
MED23	3	NCOA2	2	bioid	Lambert JP (2015)	1
RXRA	1	MED1	4	imaging technique, pull down, two hybrid, two hybrid	Sinkkonen L (2005), Yang W (2000), Shao G (2000), Osburn DL (2001)	4
DNMT3L	2	RXRA	1	pull down	Pacaud R (2014)	1
PSMC4	6	PSMC5	4	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Hendil KB (2009), Kaneko T (2009), Kaneko T (2009), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Albers M (2005), Albers M (2005), Huttlin EL (2017)	13
MED12	11	MED14	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Tsai KL (2013), Wan C (2015), Hein MY (2015)	4
PSMC5	4	MED4	2	affinity chromatography technology	Huttlin EL (2017)	1
MED13	11	MED24	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PPARGC1A	3	MED12	11	affinity chromatography technology, pull down	Wallberg AE (2003), Wallberg AE (2003)	2
3492	0	NR1I3	2	two hybrid	Wang J (2011)	1
NR1I3	2	NCOA3	3	pull down	Molnar F (2005)	1
HNF4A	2	MED1	4	affinity chromatography technology, pull down, pull down	Maeda Y (2002), Maeda Y (2002), Malik S (2002)	3
NR1I3	2	MED15	6	affinity chromatography technology	Huttlin EL (2015)	1