PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMAD3	1	MCM3AP	6	two hybrid	Colland F (2004)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
YWHAZ	1	APP	1	pull down	Olah J (2011)	1
CALR	1	APP	1	affinity chromatography technology, imaging technique	Johnson RJ (2001), Chen TC (2014)	2
CDC25A	2	TRIB3	0	affinity chromatography technology	Sakai S (2010)	1
EGLN3	0	STIP1	1	affinity chromatography technology	Rodriguez J (2016)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
CUL1	7	EEF1A1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	YWHAG	5	affinity chromatography technology	Kirli K (2015)	1
RAD23A	1	EEF1A1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scanlon TC (2009), Chen L (2006), Chen L (2006)	3
CDC20	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CHEK2	2	APP	1	pull down	Olah J (2011)	1
CUL3	17	PKM	1	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	YWHAE	0	affinity chromatography technology	Yu CC (2013)	1
CUL1	7	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Michel JJ (1998)	2
EGFR	5	PIM1	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CCNA2	1	SKP1	0	affinity chromatography technology	Hein MY (2015)	1
CHEK2	2	CHEK1	2	genetic interference	Srivas R (2016)	1
VCP	6	YWHAH	0	affinity chromatography technology	Yu CC (2013)	1
FTH1	0	SOX5	11	two hybrid	Wang J (2011)	1
XPO1	8	YWHAH	0	biochemical	Kristensen AR (2012)	1
CCNB1	3	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Di Fiore B (2010), Nishiyama A (2000), Wolthuis R (2008), Desai D (1995), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
CHEK2	2	CUL1	7	affinity chromatography technology	Huh J (2013)	1
VCP	6	CHEK1	2	affinity chromatography technology	Yu CC (2013)	1
CDC25A	2	CDK3	0	affinity chromatography technology	Li X (2016)	1
PTP4A1	0	APP	1	pull down	Olah J (2011)	1
EGFR	5	STIP1	1	protein complementation assay	Deribe YL (2009)	1
CDC25A	2	MTAP	3	two hybrid	Wang J (2011)	1
SRC	2	CDC25A	2	enzymatic study	Liang J (2016)	1
CDC25A	2	XPO1	8	two hybrid	Wang J (2011)	1
VCP	6	RAF1	3	affinity chromatography technology	Yu CC (2013)	1
CDK2	0	PKM	1	affinity chromatography technology	Neganova I (2011)	1
VCP	6	YWHAG	5	affinity chromatography technology	Yu CC (2013)	1
FZR1	1	CDC25A	2	affinity chromatography technology, pull down, enzymatic study	Gao D (2009), Donzelli M (2002), Donzelli M (2002)	3
NFYA	2	APP	1	pull down	Olah J (2011)	1
VCP	6	STIP1	1	biochemical	Wan C (2015)	1
VCP	6	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li JM (2013), Riemer A (2014), Zhang Z (2015)	3
CDC25A	2	CCNB1	3	affinity chromatography technology, affinity chromatography technology	Galaktionov K (1991), Li X (2016)	2
MAPK14	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Wang J (2013)	2
BTRC	1	NPLOC4	4	affinity chromatography technology	Riemer A (2014)	1
CUL3	17	GTF2I	1	affinity chromatography technology	Bennett EJ (2010)	1
SMAD3	1	BTRC	1	affinity chromatography technology	Wan M (2004)	1
CDK2	0	YWHAZ	1	affinity chromatography technology	Neganova I (2011)	1
CCNA1	3	CDK2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, imaging technique	Sweeney C (1996), Yang R (1997), Yang R (1997), Mueller-Tidow C (2001), Brown NR (1999), Niida H (2005), Yam CH (2000), Wang H (2009), Narayanan R (2005), Harwell RM (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Peiretti A (2003), Pan ZQ (1993), Kim KS (2002), Lyapina SA (1998), Desai D (1995), Thomas DM (2004), Johnson LN (2002), Rohaly G (2005), Chen TC (2014)	22
EGFR	5	YWHAB	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
RAD23A	1	CHEK1	2	affinity chromatography technology, affinity chromatography technology, pull down	Tan X (2015), Tan X (2015), Tan X (2015)	3
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
CDK2	0	YWHAH	0	affinity chromatography technology	Neganova I (2011)	1
EGFR	5	ATXN7L3B	0	affinity chromatography technology	Tong J (2014)	1
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
RAD23A	1	CCNA2	1	pull down	Jin L (2008)	1
YWHAE	0	MAPK14	0	biochemical	Wan C (2015)	1
EGLN3	0	FAM193B	1	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	CDC20	1	affinity chromatography technology	Kirli K (2015)	1
NXF1	0	CDC25A	2	affinity chromatography technology	Castello A (2012)	1
NFYA	2	CCNA2	1	pull down	Yun J (2003)	1
CDC25A	2	CUL3	17	two hybrid	Wang J (2011)	1
CDK2	0	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Craney A (2016), Huttlin EL (2017)	4
XPO1	8	CCDC28A	0	affinity chromatography technology	Kirli K (2015)	1
CDC25A	2	FAM193B	1	two hybrid	Vinayagam A (2011)	1
CDC25A	2	FTH1	0	two hybrid	Wang J (2011)	1
CDK3	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
YWHAQ	0	CDC25A	2	pull down, affinity chromatography technology, bioid	Meek SE (2004), Yadav L (2017), Yadav L (2017)	3
CHEK1	2	FZR1	1	genetic interference	Srivas R (2016)	1
CDC25A	2	SFN	1	affinity chromatography technology	Li X (2016)	1
CUL3	17	YWHAB	1	affinity chromatography technology	Bennett EJ (2010)	1
EEF1A1	0	PKM	1	biochemical	Wan C (2015)	1
CUL1	7	PKM	1	affinity chromatography technology	Bennett EJ (2010)	1
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
VCP	6	FBXW11	2	affinity chromatography technology	Li JM (2013)	1
EGLN3	0	GTF2I	1	affinity chromatography technology	Rodriguez J (2016)	1
BTRC	1	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
CUL3	17	YWHAG	5	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	SCYL1	5	affinity chromatography technology	Yao Z (2017)	1
BTRC	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Strack P (2000), Margottin F (1998), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Watanabe N (2004), Wu G (2003), Kawakami T (2001), Hattori K (1999), Hattori K (1999), Hattori K (1999), Kitagawa M (1999), Hart M (1999), Su Y (2008), Banerjee S (2010), Winston JT (1999), Winston JT (1999), Estrabaud E (2007), Latres E (1999), Latres E (1999), Liu J (2004), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Busino L (2012), Li T (2005), da Silva Almeida AC (2013), Sahasrabuddhe AA (2014), Choi BH (2014), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Deng W (2015), Coyaud E (2015), Liu YQ (2015), He N (2005), Kuchay S (2017), Hauri S (2016)	40
EGFR	5	PDIA3	0	affinity chromatography technology	Foerster S (2013)	1
CDC25A	2	EGFR	5	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Wang Z (2002), Wang Z (2002), Wang Z (2002), Wang Z (2002)	4
CDK2	0	YWHAG	5	affinity chromatography technology	Neganova I (2011)	1
CDK2	0	GTF2I	1	affinity chromatography technology	Neganova I (2011)	1
EGFR	5	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2009), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
CDC25A	2	PKM	1	pull down, enzymatic study	Liang J (2016), Liang J (2016)	2
EGLN3	0	YWHAE	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	HLA-C	1	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	VCP	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Besten Wd (2012)	2
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
CDC25A	2	UBE4B	5	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	DNAJC10	3	affinity chromatography technology	Dong M (2008)	1
SMAD3	1	CDC25A	2	affinity chromatography technology, two hybrid	Ray D (2005), Wang J (2011)	2
MAP3K5	1	RAF1	3	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Chen J (2001), Chen J (2001), Ivanov AA (2017)	3
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
CDC25A	2	PDIA3	0	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
CDC25A	2	PEX19	2	two hybrid	Wang J (2011)	1
PKM	1	EGLN3	0	affinity chromatography technology, pull down	Luo W (2011), Luo W (2011)	2
EGFR	5	RAF1	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CUL3	17	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	CSNK1A1	1	affinity chromatography technology	Tong J (2014)	1
CCNA2	1	CDC20	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Di Fiore B (2010), Di Fiore B (2010), Di Fiore B (2010), Wolthuis R (2008), Wolthuis R (2008), Ge S (2009), Townsend K (2009), Di Fiore B (2010), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Huttlin EL (2017), Izawa D (2012), Hein JB (2016)	25
TRIB3	0	APP	1	pull down	Olah J (2011)	1
YWHAZ	1	SFN	1	biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	3
CUL1	7	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC25A	2	NFKBIB	2	two hybrid	Wang J (2011)	1
CSNK1A1	1	CDC25A	2	enzymatic study	Honaker Y (2010)	1
BTRC	1	CCNE1	1	enzymatic study, enzymatic study	Saha A (2008), Pierce NW (2013)	2
CDC25A	2	RAD23A	1	affinity chromatography technology	Li X (2016)	1
MAP3K5	1	DMD	6	two hybrid	Bandyopadhyay S (2010)	1
EGLN3	0	YWHAZ	1	affinity chromatography technology	Rodriguez J (2016)	1
CAMK1D	4	APP	1	pull down	Olah J (2011)	1
FBXW11	2	YWHAE	0	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
LMO2	2	SKP1	0	two hybrid	Rolland T (2014)	1
CCNI	2	CDC25A	2	two hybrid	Wang J (2011)	1
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
CUL1	7	DNAJC10	3	affinity chromatography technology	Bennett EJ (2010)	1
NXF1	0	ROCK1	6	affinity chromatography technology	Castello A (2012)	1
CUL1	7	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina SA (1998), Huttlin EL (2015), Huttlin EL (2017)	4
CDC25A	2	LMO2	2	two hybrid	Wang J (2011)	1
BTRC	1	PPM1G	1	bioid	Coyaud E (2015)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
EGLN3	0	POLR1D	4	affinity chromatography technology	Rodriguez J (2016)	1
YWHAQ	0	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ewing RM (2007), Yeung K (2000), Van Der Hoeven PC (2000), Liu YC (1996), Subramanian RR (2001), ONeill E (2004), Rajalingam K (2005), Zhu J (2005), Bonnefoy-Berard N (1995), So J (2015)	10
EGLN3	0	SKP1	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAZ	1	RAF1	3	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Clark GJ (1997), Tzivion G (2000), Tzivion G (2000), Koyama S (1995), Koyama S (1995), Van Der Hoeven PC (2000), Chow CW (2000), Andersen SD (2012), Subramanian RR (2001), Wang H (1998), Wang H (1998), Wang H (1998), Dougherty MK (2005), Rajalingam K (2005), Zhu J (2005), So J (2015), Powell DW (2003), Ivanov AA (2017)	18
CDK2	0	NFYA	2	enzymatic study, pull down, affinity chromatography technology	Yun J (2003), Yun J (2003), Yun J (2003)	3
PKM	1	NPLOC4	4	biochemical	Kristensen AR (2012)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PPM1G	1	affinity chromatography technology	Rodriguez J (2016)	1
YWHAQ	0	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
CDC20	1	CUL1	7	affinity chromatography technology	Wu F (2017)	1
CDC20	1	CCNA1	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Ohtoshi A (2000), Ohtoshi A (2000), Gao D (2009)	3
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
APP	1	SRC	2	affinity chromatography technology	Austin SA (2009)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
BTRC	1	CCNB1	3	affinity chromatography technology, affinity chromatography technology	Herrero-Ruiz J (2014), Herrero-Ruiz J (2014)	2
CDK2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Fogeron ML (2013)	2
DUSP7	3	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
CDK5	0	APP	1	pull down	Olah J (2011)	1
CDC25A	2	MCM3AP	6	two hybrid	Wang J (2011)	1
CDC20	1	CUL3	17	affinity chromatography technology	Wu F (2017)	1
IPO5	0	SFN	1	biochemical	Wan C (2015)	1
CDC25A	2	SOX5	11	two hybrid	Wang J (2011)	1
CUL3	17	EEF1A1	0	affinity chromatography technology	Bennett EJ (2010)	1
FZR1	1	MAP3K5	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
SFN	1	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Benzinger A (2005), Subramanian RR (2001), Rajalingam K (2005), Zhu J (2005), So J (2015), Mo XL (2015)	6
EGLN3	0	CDC20	1	affinity chromatography technology	Rodriguez J (2016)	1
CDC25A	2	DMD	6	two hybrid	Wang J (2011)	1
CCNE1	1	CDC25A	2	affinity chromatography technology, pull down	Shanahan F (1999), Xu X (1996)	2
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
CDC25A	2	DUSP8	0	two hybrid	Vinayagam A (2011)	1
CDK5	0	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2017)	3
CDC25A	2	CCDC28A	0	affinity chromatography technology	Li X (2016)	1
YWHAQ	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pozuelo-Rubio M (2010), Huttlin EL (2015), Huttlin EL (2017)	3
VCP	6	PKM	1	affinity chromatography technology	Yu CC (2013)	1
CHEK2	2	FZR1	1	genetic interference	Srivas R (2016)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
YWHAG	5	MAP3K5	1	affinity chromatography technology	Wang H (2015)	1
VCP	6	CALR	1	biochemical	Wan C (2015)	1
CDC25A	2	HLA-C	1	two hybrid	Wang J (2011)	1
MAP3K5	1	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Zhang L (1999), So J (2015)	2
LMO2	2	ROCK1	6	two hybrid	Rolland T (2014)	1
CUL1	7	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
CCNA2	1	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC25A	2	MAP3K5	1	two hybrid, affinity chromatography technology, pull down	Zou X (2001), Zou X (2001), Zou X (2001)	3
MAPK14	0	EGFR	5	enzymatic study	Raingeaud J (1995)	1
YWHAQ	0	PKM	1	pull down	Meek SE (2004)	1
CDK5	0	STIP1	1	affinity chromatography technology	Varjosalo M (2013)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
DMD	6	APP	1	pull down	Olah J (2011)	1
EGLN3	0	CDC25A	2	affinity chromatography technology	Rodriguez J (2016)	1
MAPK14	0	PPM1G	1	biochemical	Wan C (2015)	1
FBXW11	2	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1
SFN	1	EEF1A1	0	far western blotting	Wilker EW (2007)	1
CDC25A	2	IPO5	0	affinity chromatography technology	Li X (2016)	1
CUL1	7	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC25A	2	ATXN7L3B	0	affinity chromatography technology	Li X (2016)	1
CDC25A	2	NPLOC4	4	affinity chromatography technology	Riemer A (2014)	1
EGFR	5	YWHAQ	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
NXF1	0	EEF1A1	0	affinity chromatography technology	Castello A (2012)	1
CDK2	0	YWHAQ	0	affinity chromatography technology	Neganova I (2011)	1
SRC	2	CCNA1	3	two hybrid	Narayanan R (2005)	1
SMAD3	1	APP	1	pull down	Olah J (2011)	1
CDC25A	2	VAMP8	0	two hybrid	Wang J (2011)	1
CUL3	17	YWHAH	0	affinity chromatography technology	Bennett EJ (2010)	1
SMAD3	1	CUL1	7	affinity chromatography technology	Ray D (2005)	1
CHEK1	2	SFN	1	affinity chromatography technology	Tian H (2002)	1
YWHAE	0	CALR	1	biochemical	Wan C (2015)	1
CDC25A	2	CALR	1	affinity chromatography technology	Yadav L (2017)	1
CDK3	0	STIP1	1	affinity chromatography technology	Varjosalo M (2013)	1
RAF1	3	YWHAB	1	two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yuryev A (2003), Truong AB (2002), Van Der Hoeven PC (2000), Yuryev A (2000), Vincenz C (1996), Conklin DS (1995), Subramanian RR (2001), Rajalingam K (2005), Zhu J (2005), Couzens AL (2013), So J (2015)	11
PDIA3	0	APP	1	pull down, pull down	Olah J (2011), Erickson RR (2005)	2
EGLN3	0	NPLOC4	4	affinity chromatography technology	Rodriguez J (2016)	1
NXF1	0	YWHAZ	1	affinity chromatography technology	Castello A (2012)	1
CDK2	0	PDIA3	0	affinity chromatography technology	Neganova I (2011)	1
CDC25A	2	YWHAE	0	two hybrid	Conklin DS (1995)	1
NFKBIB	2	APP	1	pull down	Olah J (2011)	1
FZR1	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ROCK1	6	CDC25A	2	enzymatic study	Bhowmick NA (2003)	1
CDC25A	2	PTP4A1	0	affinity chromatography technology	Li X (2016)	1
RAF1	3	PKM	1	two hybrid	Yuryev A (2003)	1
EGLN3	0	CDK2	0	affinity chromatography technology	Rodriguez J (2016)	1
IPO5	0	XPO1	8	biochemical	Wan C (2015)	1
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
NXF1	0	NFYA	2	affinity chromatography technology	Castello A (2012)	1
CUL1	7	FZR1	1	affinity chromatography technology, affinity chromatography technology	Fukushima H (2013), Fukushima H (2013)	2
CDC25A	2	CCNA2	1	affinity chromatography technology	Li X (2016)	1
CCNA1	3	CDC25A	2	affinity chromatography technology, affinity chromatography technology	Liu D (2000), Li X (2016)	2
CHEK1	2	CDC25A	2	pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Goloudina A (2003), Sanchez Y (1997), Sanchez Y (1997), Zhao H (2002), Jin J (2008), Hassepass I (2003), Sorensen CS (2003), Li X (2016)	8
CDC25A	2	FAM91A1	1	affinity chromatography technology	Li X (2016)	1
FZR1	1	CCNA1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sorensen CS (2001), Sorensen CS (2001), Gao D (2009), Fukushima H (2013)	4
NXF1	0	BTRC	1	affinity chromatography technology	Castello A (2012)	1
BTRC	1	GOPC	5	bioid	Coyaud E (2015)	1
CDC25A	2	WDR11	4	affinity chromatography technology	Li X (2016)	1
MAPK14	0	DUSP7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
CUL3	17	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC25A	2	CDK2	0	pull down, enzymatic study, affinity chromatography technology	Xu X (1996), Cheng A (2005), Li X (2016)	3
VCP	6	YWHAQ	0	affinity chromatography technology	Yu CC (2013)	1
CHEK1	2	XPO1	8	pull down	Jiang K (2003)	1
CDK2	0	YWHAE	0	affinity chromatography technology	Neganova I (2011)	1
EGLN3	0	GOPC	5	affinity chromatography technology	Rodriguez J (2016)	1
STIP1	1	APP	1	pull down	Olah J (2011)	1
CDK5	0	CCNI	2	affinity chromatography technology	So J (2015)	1
BTRC	1	NFKBIB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Wu C (1999), Shirane M (1999), Coyaud E (2015), Coyaud E (2015)	4
CDK5	0	CCNB1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	5
CHEK1	2	SRC	2	genetic interference	Shen JP (2017)	1
PIM1	2	FZR1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Cen B (2010), Cen B (2010), Cen B (2010)	3
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
CUL1	7	CHEK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu S (2009), Huh J (2013), Zhang YW (2005)	3
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CUL1	7	CDK3	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC25A	2	155100	0	affinity chromatography technology	Li X (2016)	1
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
MAPK14	0	EEF1A1	0	two hybrid	Wang J (2008)	1
XPO1	8	DUSP7	3	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	NFKBIB	2	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	MAP3K5	1	affinity chromatography technology	Rodriguez J (2016)	1
CDK5	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
RAF1	3	NPLOC4	4	two hybrid	Johnson SE (2006)	1
CAMK1D	4	XPO1	8	biochemical	Kristensen AR (2012)	1
FBXW11	2	CDK5	0	affinity chromatography technology	Low TY (2014)	1
BTRC	1	UBE4B	5	affinity chromatography technology, affinity chromatography technology	Loveless TB (2015), Loveless TB (2015)	2
CDK5	0	FZR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang J (2012), Cataldo F (2013), Maestre C (2008), Maestre C (2008)	4
YWHAQ	0	MAP3K5	1	pull down	Zhang H (2007)	1
XPO1	8	CCNB1	3	affinity chromatography technology	Kirli K (2015)	1
FBXW11	2	UBE4B	5	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Loveless TB (2015)	2
RAF1	3	YWHAE	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vincenz C (1996), Conklin DS (1995), Subramanian RR (2001), Gloeckner CJ (2007), Rajalingam K (2005), Zhu J (2005), Choudhary C (2009), Choudhary C (2009), So J (2015)	9
EGLN3	0	NAA10	9	affinity chromatography technology	Rodriguez J (2016)	1
MAP3K5	1	APP	1	imaging technique	Chen TC (2014)	1
XPO1	8	CSNK1A1	1	affinity chromatography technology	Kirli K (2015)	1
CDK2	0	EEF1A1	0	affinity chromatography technology	Neganova I (2011)	1
YWHAB	1	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
CDK2	0	CALR	1	affinity chromatography technology	Neganova I (2011)	1
LMO2	2	SOX5	11	two hybrid	Rolland T (2014)	1
YWHAB	1	APP	1	pull down	Olah J (2011)	1
SCYL1	5	APP	1	pull down	Olah J (2011)	1
CDC25A	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2003), Donzelli M (2004), Busino L (2003), Donzelli M (2002), He N (2005), Li X (2016)	6
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
VCP	6	CHEK2	2	affinity chromatography technology	Matsuoka S (2007)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
UBE4B	5	RAD23A	1	pull down	Goh AM (2008)	1
EGLN3	0	YWHAQ	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAG	5	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Autieri MV (1999), Van Der Hoeven PC (2000), Rajalingam K (2005), Zhu J (2005), So J (2015), Ivanov AA (2017)	7
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
CDC25A	2	YWHAB	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Conklin DS (1995), Conklin DS (1995), Conklin DS (1995), Li X (2016), Yadav L (2017), Yadav L (2017)	6
CDC25A	2	YWHAG	5	affinity chromatography technology, affinity chromatography technology, bioid	Li X (2016), Yadav L (2017), Yadav L (2017)	3
CCNB1	3	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	3
NXF1	0	NPLOC4	4	affinity chromatography technology	Castello A (2012)	1
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
YWHAE	0	VAMP8	0	affinity chromatography technology	Gloeckner CJ (2007)	1
FBXW11	2	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
YWHAE	0	CSNK1A1	1	affinity chromatography technology	Gloeckner CJ (2007)	1
XPO1	8	DMD	6	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	EEF1A1	0	affinity chromatography technology	Foerster S (2013)	1
NFKBIB	2	FBXW11	2	imaging technique	Chen TC (2014)	1
VCP	6	CCNB1	3	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
RAF1	3	CDC25A	2	affinity chromatography technology, pull down, affinity chromatography technology	Galaktionov K (1995), Galaktionov K (1995), Huang TS (1997)	3
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
EGLN3	0	CDK5	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAZ	1	CDC25A	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Wang Z (2002), Li X (2016), Huttlin EL (2017)	3
CDK3	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CUL1	7	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015)	2
YWHAZ	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
FTH1	0	YWHAE	0	two hybrid	Wang J (2011)	1
UBE4B	5	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsumoto M (2004), Matsumoto M (2004), Boehm S (2011), Takahata M (2008), Morreale G (2009), Fernandez-Saiz V (2010), Fernandez-Saiz V (2010), Raman M (2015), Wang T (2016), Huttlin EL (2017)	10
EGLN3	0	CSNK1A1	1	affinity chromatography technology	Rodriguez J (2016)	1
BTRC	1	CDC25A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Ray D (2005), Jin J (2003), Jin J (2003), Honaker Y (2010), Honaker Y (2010), Gao D (2009), Donzelli M (2004), Donzelli M (2004), Jin J (2005), Busino L (2003), Busino L (2003), Busino L (2003), Busino L (2003), Kim TY (2014), Jin J (2003), Coyaud E (2015), Loveless TB (2015), Coyaud E (2015), He N (2005), He N (2005), St-Denis N (2016), Huttlin EL (2017)	23
CDC25A	2	NFYA	2	two hybrid	Wang J (2011)	1
NXF1	0	GOPC	5	affinity chromatography technology	Castello A (2012)	1
CAMK1D	4	CDC25A	2	two hybrid	Wang J (2011)	1
CDC25A	2	SCYL1	5	two hybrid	Wang J (2011)	1
LMO2	2	STIP1	1	two hybrid	Wang J (2011)	1
TRIB3	0	MCM3AP	6	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
XPO1	8	MCM3AP	6	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	PEX19	2	affinity chromatography technology	Foerster S (2013)	1
CDC25A	2	EEF1A1	0	two hybrid	Wang J (2011)	1
EGFR	5	SFN	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Li J (2013)	5
PKM	1	APP	1	pull down	Olah J (2011)	1
CUL3	17	YWHAQ	0	affinity chromatography technology	Bennett EJ (2010)	1
CCNE1	1	CUL3	17	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singer JD (1999), Singer JD (1999), Singer JD (1999), Wimuttisuk W (2007), Jin X (2016), Jin X (2016), Jin X (2016)	7
CDC25A	2	IL3RA	0	two hybrid	Wang J (2011)	1
RAD23A	1	VCP	6	affinity chromatography technology	Laco MN (2012)	1
CDK2	0	SKP1	0	x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao ZP (2006), Lyapina SA (1998), Zhang H (1995), Varjosalo M (2013), So J (2015), Hein MY (2015)	6
NXF1	0	CCNI	2	affinity chromatography technology	Castello A (2012)	1
CCNB1	3	FZR1	1	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Ke PY (2004), Huang NJ (2012), Pfleger CM (2001), Miller JJ (2006), Song MS (2011), Frye JJ (2013), Lau AW (2013), Brown NG (2014), Summers MK (2009), ODonovan KJ (2010), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Lu L (2013), Yamaguchi M (2015), Brown NG (2015), Chen TC (2014), Williamson A (2011), Qiao R (2016), Brown NG (2016), Huttlin EL (2017)	22
BTRC	1	YWHAZ	1	affinity chromatography technology	Coyaud E (2015)	1
FBXW11	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Watanabe N (2004), Fuchs SY (1999), Tan P (1999), Herter JR (2002), Lievens S (2009), Lievens S (2009), DAnnibale S (2014), Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Hein MY (2015), Liu X (2017), Hauri S (2016)	16
CDC25A	2	GOPC	5	affinity chromatography technology	Li X (2016)	1
CDK5	0	CDC25A	2	enzymatic study	Chang KH (2012)	1
EGFR	5	CDK5	0	affinity chromatography technology	Tong J (2014)	1
CUL3	17	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXW11	2	CDC25A	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Ray D (2005), Ray D (2005), Jin J (2003), Jin J (2005), Gao D (2011), Busino L (2003), Busino L (2003), Kim TY (2014), Jin J (2003), Coyaud E (2015), Low TY (2014), St-Denis N (2016), Li X (2016), Huttlin EL (2017), Liu X (2017), Liu X (2017), Yadav L (2017), Yadav L (2017)	18
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
CDK2	0	SMAD3	1	enzymatic study, imaging technique	Matsuura I (2004), Chen TC (2014)	2
CCNA2	1	FZR1	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Jin L (2008), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Williamson A (2011), Huttlin EL (2017), Choudhury R (2016)	8
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
FBXW11	2	FAM193B	1	affinity chromatography technology	Low TY (2014)	1
CDC20	1	CCNB1	3	enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Garnett MJ (2009), ODonovan KJ (2010), Ke PY (2004), Braunstein I (2007), van Zon W (2010), van Zon W (2010), Pfleger CM (2001), Wolthuis R (2008), Kwan PS (2013), Tian W (2012), Han JS (2013), Lim HJ (2013), Han JS (2014), Brown NG (2014), Townsend K (2009), Sedgwick GG (2013), Lara-Gonzalez P (2011), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Wu T (2010), Uzunova K (2012), Shoji S (2014), Sedgwick GG (2013), Lara-Gonzalez P (2011), Diaz-Martinez LA (2015), Brown NG (2015), Lischetti T (2014), Tipton AR (2013), Lee SB (2015), Lee SB (2015), Jia L (2016)	33
CDC25A	2	CDC20	1	affinity chromatography technology	Li X (2016)	1
VCP	6	YWHAB	1	affinity chromatography technology	Yu CC (2013)	1
CDC25A	2	PPM1G	1	affinity chromatography technology	Yadav L (2017)	1
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	VCP	6	affinity chromatography technology	Rodriguez J (2016)	1
CHEK2	2	CDC25A	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Jin J (2008), Hassepass I (2003), Sorensen CS (2003), Falck J (2001), Falck J (2001)	5
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
MTAP	3	PDIA3	0	biochemical	Kristensen AR (2012)	1
EEF1A1	0	GTF2I	1	biochemical	Havugimana PC (2012)	1
VCP	6	PEX19	2	affinity chromatography technology, affinity chromatography technology	Murakami K (2013), Murakami K (2013)	2
CAMK1D	4	CUL3	17	two hybrid	Wang J (2011)	1
BTRC	1	FZR1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Fukushima H (2013)	3
CDC25A	2	YWHAH	0	affinity chromatography technology, affinity chromatography technology, bioid	Li X (2016), Yadav L (2017), Yadav L (2017)	3
CALR	1	PDIA3	0	affinity chromatography technology, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Oliver JD (1999), Oliver JD (1999), Oliver JD (1999), Oliver JD (1999), Leach MR (2002), Wan C (2015), Tan P (2002), Tan P (2002)	8
CDC25A	2	APOLD1	0	affinity chromatography technology	Li X (2016)	1
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
BTRC	1	YWHAE	0	affinity chromatography technology	Coyaud E (2015)	1
EGFR	5	IPO5	0	affinity chromatography technology	Foerster S (2013)	1
XPO1	8	FAM91A1	1	affinity chromatography technology	Kirli K (2015)	1
SOX5	11	APP	1	pull down	Olah J (2011)	1
CDC25A	2	DUSP7	3	affinity chromatography technology	Li X (2016)	1
SRC	2	RAF1	3	affinity chromatography technology, pull down	Cleghon V (1994), Cleghon V (1994)	2
PIM1	2	CDC20	1	affinity chromatography technology, enzymatic study	Cen B (2010), Cen B (2010)	2
YWHAE	0	XPO1	8	biochemical	Kristensen AR (2012)	1
CDC25A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Donzelli M (2004), Busino L (2003), Donzelli M (2002), He N (2005), Li X (2016), Yadav L (2017), Yadav L (2017)	7
MAPK14	0	CDC25A	2	pull down	Goloudina A (2003)	1
PIM1	2	CDC25A	2	pull down, affinity chromatography technology	Mochizuki T (1999), Mochizuki T (1999)	2
CDK3	0	SKP1	0	affinity chromatography technology	Varjosalo M (2013)	1
XPO1	8	PEX19	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	RAF1	3	affinity chromatography technology	Kirli K (2015)	1
BTRC	1	CSNK1A1	1	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
FBXW11	2	GTF2I	1	affinity chromatography technology	Low TY (2014)	1
XPO1	8	SCYL1	5	affinity chromatography technology	Kirli K (2015)	1
CDC25A	2	CDC25A	2	affinity chromatography technology	Li X (2016)	1
VCP	6	YWHAZ	1	affinity chromatography technology, two hybrid	Yu CC (2013), Wang J (2011)	2
CDK3	0	APP	1	pull down	Olah J (2011)	1
CDC25A	2	FGF21	0	two hybrid	Wang J (2011)	1
SKP1	0	YWHAG	5	biochemical	Wan C (2015)	1
EGFR	5	CALR	1	affinity chromatography technology	Tong J (2014)	1
CDK2	0	FZR1	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Sorensen CS (2001), Fukushima H (2013), Lau AW (2013), Chang L (2015), Huttlin EL (2017)	5
EGFR	5	NAA10	9	affinity chromatography technology	Tong J (2014)	1
CDC25A	2	NAA10	9	two hybrid	Rual JF (2005)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
YWHAQ	0	EEF1A1	0	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
SFN	1	YWHAB	1	affinity chromatography technology	Huttlin EL (2017)	1
CDK5	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
CDC25A	2	STIP1	1	affinity chromatography technology	Li X (2016)	1
SMAD3	1	TRIB3	0	affinity chromatography technology, affinity chromatography technology	Hua F (2011), Hua F (2011)	2
CDC25A	2	POLR1D	4	two hybrid	Wang J (2011)	1
CDC25A	2	APP	1	pull down	Olah J (2011)	1
CHEK1	2	APP	1	pull down	Olah J (2011)	1
CDC25A	2	GTF2I	1	affinity chromatography technology	Li X (2016)	1
NXF1	0	RAF1	3	affinity chromatography technology	Castello A (2012)	1
EEF1A1	0	RAF1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Lamberti A (2007), Lamberti A (2007), Lamberti A (2007)	3
FBXW11	2	YWHAZ	1	affinity chromatography technology	Coyaud E (2015)	1
CDK2	0	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CUL3	17	DNAJC10	3	affinity chromatography technology	Bennett EJ (2010)	1
CDC25A	2	DNAJC10	3	affinity chromatography technology	Li X (2016)	1
FAM193B	1	CUL3	17	affinity chromatography technology	Rutz N (2015)	1
PIM1	2	APP	1	pull down	Olah J (2011)	1
EGLN3	0	IPO5	0	affinity chromatography technology	Rodriguez J (2016)	1
CDC20	1	BTRC	1	affinity chromatography technology	Guardavaccaro D (2008)	1
EGLN3	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
CDC25A	2	VCP	6	affinity chromatography technology	Riemer A (2014)	1
FBXW11	2	WDR11	4	affinity chromatography technology	Low TY (2014)	1
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54
CUL3	17	IPO5	0	affinity chromatography technology	Bennett EJ (2010)	1
YWHAH	0	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ichimura T (2002), Van Der Hoeven PC (2000), Vincenz C (1996), Subramanian RR (2001), Rajalingam K (2005), Zhu J (2005), So J (2015), Hein MY (2015), Hein MY (2015)	9
BTRC	1	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1