PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FCHSD2	3	HSPA5	0	two hybrid	Thalappilly S (2008)	1
FCHSD2	3	FAM9B	0	two hybrid	Rolland T (2014)	1
DAPP1	2	FCHSD2	3	two hybrid	Wang J (2011)	1
FCHSD2	3	HSP90AB1	2	two hybrid	Thalappilly S (2008)	1
WASL	2	HSP90AB1	2	pull down, pull down	Park SJ (2005), Park SJ (2005)	2
CCT2	1	HSP90AB1	2	pull down	Lin YF (2012)	1
ELAVL1	0	FCHSD2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	WASL	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	CASK	18	affinity chromatography technology	Abdelmohsen K (2009)	1
FCHSD2	3	MTUS2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ITSN2	7	PDE4DIP	10	two hybrid	Wong KA (2012)	1
GOPC	5	FCHSD2	3	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	HSP90AB1	2	affinity chromatography technology	Yu CC (2013)	1
GOPC	5	FAM9B	0	two hybrid	Rolland T (2014)	1
KIFC3	3	FCHSD2	3	two hybrid	Rolland T (2014)	1
ITSN1	5	FCHSD2	3	two hybrid	Wong KA (2012)	1
ITSN1	5	ITSN2	7	protein complementation assay	Wong KA (2012)	1
PDE4DIP	10	MTUS2	4	two hybrid	Rolland T (2014)	1
FCHSD2	3	CCDC158	4	two hybrid	Rual JF (2005)	1
FCHSD2	3	CHKA	1	two hybrid	Thalappilly S (2008)	1
HSPA5	0	HSP90AB1	2	biochemical	Havugimana PC (2012)	1
FCHSD2	3	VCP	6	two hybrid, affinity chromatography technology	Thalappilly S (2008), Thalappilly S (2008)	2
FCHSD2	3	CASK	18	pull down	Ohno H (2003)	1
ITSN2	7	FCHSD2	3	two hybrid	Wong KA (2012)	1
HSPA5	0	ABCF3	1	affinity chromatography technology	Hein MY (2015)	1
PDE4DIP	10	FCHSD2	3	two hybrid	Rolland T (2014)	1
FCHSD2	3	SH3BGR	0	two hybrid	Thalappilly S (2008)	1
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
ITSN1	5	WASL	2	pull down	Hussain NK (2001)	1
FCHSD2	3	WASL	2	two hybrid	Wang J (2011)	1
FCHSD2	3	CFAP36	1	two hybrid	Thalappilly S (2008)	1
WAS	0	ITSN2	7	two hybrid, affinity chromatography technology, pull down, two hybrid	McGavin MK (2001), McGavin MK (2001), McGavin MK (2001), Wong KA (2012)	4
ITSN1	5	WAS	0	affinity chromatography technology, affinity chromatography technology	Tsyba L (2008), Wang JB (2005)	2
FCHSD2	3	VCPIP1	4	two hybrid	Thalappilly S (2008)	1
FCHSD2	3	FCHSD2	3	pull down	McDonald NA (2015)	1
FCHSD2	3	CCT2	1	two hybrid	Thalappilly S (2008)	1
FCHSD2	3	ABCF3	1	two hybrid	Rolland T (2014)	1
FCHSD2	3	MSL1	0	two hybrid	Thalappilly S (2008)	1
FCHSD2	3	CCDC85B	0	two hybrid	Rual JF (2005)	1
ELAVL1	0	PDE4DIP	10	affinity chromatography technology	Abdelmohsen K (2009)	1
VCP	6	HSPA5	0	affinity chromatography technology	Yu CC (2013)	1
FCHSD2	3	SRP72	5	two hybrid	Thalappilly S (2008)	1
FCHSD2	3	C2orf73	2	two hybrid	Thalappilly S (2008)	1
CCT2	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology	Lin YF (2012), Lin YF (2012), Yu CC (2013)	3
ITSN2	7	WASL	2	two hybrid	Wong KA (2012)	1
VCPIP1	4	VCP	6	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Totsukawa G (2011), Totsukawa G (2013), Totsukawa G (2013), Zhang X (2014), Raman M (2015)	6
FCHSD2	3	WAS	0	two hybrid	Wang J (2011)	1
MAGI1	3	FCHSD2	3	two hybrid, pull down, affinity chromatography technology	Ohno H (2003), Ohno H (2003), Ohno H (2003)	3
ITSN1	5	MTUS2	4	two hybrid	Wong KA (2012)	1
FCHSD2	3	C9orf78	0	two hybrid	Thalappilly S (2008)	1