PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKN	1	TOMM70	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Okatsu K (2012), Sarraf SA (2013), Sarraf SA (2013), Bertolin G (2013), Bertolin G (2013), Bertolin G (2013), Zanon A (2013), Zanon A (2013), Bertolin G (2015)	9
EGFR	5	RAB1A	0	affinity chromatography technology	Yao Z (2017)	1
PINK1	2	TRAF6	0	affinity chromatography technology, enzymatic study	Lee HJ (2012), Murata H (2013)	2
TMEM173	0	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TOMM20	0	TOMM40	1	affinity chromatography technology, biochemical, pull down	Lazarou M (2012), Havugimana PC (2012), Humphries AD (2005)	3
PINK1	2	IRAK1	1	affinity chromatography technology, affinity chromatography technology	Lee HJ (2012), Lee HJ (2012)	2
TOMM22	0	TOMM70	1	biochemical	Havugimana PC (2012)	1
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
RIPK4	0	HSP90AA1	7	affinity chromatography technology	Rodriguez J (2016)	1
UNK	3	RAB1A	0	affinity chromatography technology	Murn J (2015)	1
NTRK1	1	HSPB1	2	affinity chromatography technology	Emdal KB (2015)	1
DHX9	3	HNRNPM	1	biochemical	Kristensen AR (2012)	1
EGLN3	0	SFXN2	1	affinity chromatography technology	Rodriguez J (2016)	1
ABCC2	2	TOMM20	0	biochemical	Havugimana PC (2012)	1
TOMM40	1	TOMM70	1	biochemical	Havugimana PC (2012)	1
TIMM50	4	TOMM70	1	biochemical	Havugimana PC (2012)	1
SFXN1	0	TOMM70	1	biochemical	Havugimana PC (2012)	1
RIPK4	0	SFXN2	1	affinity chromatography technology	Rodriguez J (2016)	1
ABCC2	2	TOMM70	1	biochemical	Havugimana PC (2012)	1
SDHA	2	TOMM70	1	biochemical	Havugimana PC (2012)	1
MCM2	3	TOMM70	1	affinity chromatography technology	Drissi R (2015)	1
STAU1	1	HNRNPM	1	affinity chromatography technology	Milev MP (2012)	1
RIPK4	0	IRAK1	1	affinity chromatography technology	Rodriguez J (2016)	1
TOMM22	0	TOMM7	0	biochemical	Havugimana PC (2012)	1
IRF3	4	HSP90AA1	7	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Yang K (2006), Yang K (2006), Yang K (2006), Liu XY (2010), Liu XY (2010)	5
RIPK4	0	TOMM70	1	affinity chromatography technology	Rodriguez J (2016)	1
PINK1	2	TOMM22	0	affinity chromatography technology	Lazarou M (2012)	1
TOMM20	0	TOMM7	0	biochemical	Havugimana PC (2012)	1
IRF3	4	TOMM70	1	affinity chromatography technology, affinity chromatography technology, pull down	Liu XY (2010), Liu XY (2010), Liu XY (2010)	3
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
HSP90AA1	7	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang K (2006), Taipale M (2012), Liu XY (2010)	3
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
TOMM20	0	TRAF6	0	affinity chromatography technology	Murata H (2013)	1
MCM2	3	TIMM50	4	affinity chromatography technology	Drissi R (2015)	1
SFXN1	0	TOMM20	0	biochemical	Havugimana PC (2012)	1
TOMM70	1	TOMM7	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	TOMM70	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	MCM2	3	affinity chromatography technology	Emdal KB (2015)	1
MCM2	3	TBK1	1	affinity chromatography technology	Drissi R (2015)	1
TRADD	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chang YL (2014), Chang YL (2014)	2
STAU1	1	SFXN1	0	affinity chromatography technology	Milev MP (2012)	1
FOXL1	0	TOMM40	1	affinity chromatography technology	Li X (2015)	1
TOMM70	1	HSP90AA1	7	affinity chromatography technology, pull down	Liu XY (2010), Liu XY (2010)	2
PTBP1	2	TOMM70	1	biochemical	Wan C (2015)	1
RNF185	1	TOMM70	1	affinity chromatography technology	Iioka H (2007)	1
TBK1	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Wang L (2012), Liu XY (2011), Liu S (2015), Fang R (2017), Zhang Q (2017)	7
EGFR	5	IRAK1	1	affinity chromatography technology	Yao Z (2017)	1
IRAK1	1	HSPB1	2	affinity chromatography technology	So J (2015)	1
SDHA	2	SFXN1	0	affinity chromatography technology	Malty RH (2017)	1
TOMM70	1	RAB1A	0	biochemical	Wan C (2015)	1
LAMTOR3	0	PTPN1	2	biochemical	Havugimana PC (2012)	1
SFXN2	1	TOMM70	1	biochemical	Havugimana PC (2012)	1
NTRK1	1	STAU1	1	affinity chromatography technology	Emdal KB (2015)	1
STAU1	1	TOMM70	1	affinity chromatography technology	Milev MP (2012)	1
IRF3	4	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Liu S (2015), Liu S (2015), Zhou Z (2014)	6
MCM2	3	DHX9	3	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	SDHA	2	affinity chromatography technology	Emdal KB (2015)	1
PTPN5	0	TOMM70	1	affinity chromatography technology	St-Denis N (2016)	1
PRKN	1	HNRNPM	1	affinity chromatography technology	Zanon A (2013)	1
HSPB1	2	HSP90AA1	7	two hybrid	Katsogiannou M (2014)	1
MCM2	3	PTBP1	2	affinity chromatography technology	Drissi R (2015)	1
TOMM22	0	TOMM40	1	affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology	Ott M (2007), Lazarou M (2012), Havugimana PC (2012), Humphries AD (2005), Huttlin EL (2017)	5
TOMM70	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology	Liu XY (2010), Liu XY (2010)	2
PINK1	2	TOMM40	1	affinity chromatography technology, affinity chromatography technology	Lazarou M (2012), Ando M (2017)	2
FOXL1	0	TOMM70	1	affinity chromatography technology	Li X (2015)	1
TOMM70	1	TRADD	0	affinity chromatography technology	Liu XY (2010)	1
DHX9	3	TOMM70	1	biochemical	Havugimana PC (2012)	1
PRKN	1	MAVS	1	affinity chromatography technology, affinity chromatography technology	Khan M (2016), Khan M (2016)	2
TOMM40	1	TOMM7	0	biochemical	Havugimana PC (2012)	1
EGFR	5	TOMM22	0	affinity chromatography technology	Tong J (2014)	1
TMEM173	0	MAVS	1	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Chen X (2014)	2
TBK1	1	IRF3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Friedman CS (2008), Li S (2011), Li S (2011), Cui J (2012), Piao W (2009), Nakhaei P (2012), Ikeda F (2007), Ikeda F (2007), Ng MH (2011), Wang L (2012), Yang K (2006), Yang K (2006), Liu XY (2010), Liu S (2015), Liu S (2015), Freischmidt A (2015), Zhang Q (2017), Zhang Q (2017)	18
LAMTOR3	0	TOMM22	0	biochemical	Havugimana PC (2012)	1
PTPN1	2	TOMM70	1	affinity chromatography technology	St-Denis N (2016)	1
STAU1	1	DHX9	3	affinity chromatography technology, affinity chromatography technology	Milev MP (2012), Milev MP (2012)	2
PINK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2010), Weihofen A (2008), Weihofen A (2008), Moriwaki Y (2008), Moriwaki Y (2008), Taipale M (2012), Ando M (2017)	7
EGLN3	0	TOMM70	1	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	TBK1	1	affinity chromatography technology	Rodriguez J (2016)	1
EGFR	5	TOMM70	1	affinity chromatography technology	Yao Z (2017)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	DHX9	3	affinity chromatography technology	Liccardi G (2014)	1
EGLN3	0	IRAK1	1	affinity chromatography technology	Rodriguez J (2016)	1
TIMM50	4	TOMM7	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	PTBP1	2	affinity chromatography technology	Emdal KB (2015)	1
TOMM70	1	TBK1	1	affinity chromatography technology	Liu XY (2010)	1
NTRK1	1	TRAF6	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Jadhav T (2008), Geetha T (2005), Zheng C (2015)	3
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
PINK1	2	TOMM70	1	affinity chromatography technology	Lazarou M (2012)	1
IRAK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	De Nardo D (2005), De Nardo D (2005), De Nardo D (2005)	3
EGLN3	0	TOMM22	0	affinity chromatography technology	Rodriguez J (2016)	1
PTBP1	2	RAB1A	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
PRKN	1	TOMM22	0	affinity chromatography technology	Sarraf SA (2013)	1
EGFR	5	TIMM50	4	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
TMEM173	0	IRF3	4	affinity chromatography technology, affinity chromatography technology	Chen X (2014), Liu S (2015)	2
ADRB2	0	TIMM50	4	affinity chromatography technology	Roy SJ (2013)	1
EGLN3	0	SDHA	2	affinity chromatography technology	Rodriguez J (2016)	1
UNK	3	TOMM70	1	affinity chromatography technology	Murn J (2015)	1
PTBP1	2	HSPB1	2	biochemical	Wan C (2015)	1
TOMM20	0	TOMM70	1	biochemical	Havugimana PC (2012)	1
UNK	3	HSP90AA1	7	affinity chromatography technology	Murn J (2015)	1
EGLN3	0	PTPN1	2	affinity chromatography technology	Rodriguez J (2016)	1
PTPN1	2	EGFR	5	x-ray crystallography, enzymatic study, two hybrid, protein complementation assay, affinity chromatography technology, pull down, pull down	Sarmiento M (2000), Zhang ZY (1996), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Milarski KL (1993), Milarski KL (1993)	7
HSPB1	2	TOMM70	1	two hybrid	Katsogiannou M (2014)	1
TBK1	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsuchida T (2010), Li S (2011), Zhang J (2012), Zhang J (2012), Chen X (2014), Ni G (2017), Zhang Q (2017)	7
TOMM70	1	TRAF6	0	affinity chromatography technology	Liu XY (2010)	1
HNRNPM	1	TOMM70	1	biochemical	Havugimana PC (2012)	1
ABCC2	2	TOMM22	0	biochemical	Havugimana PC (2012)	1
RIPK4	0	TIMM50	4	affinity chromatography technology	Rodriguez J (2016)	1
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
LAMTOR3	0	TOMM70	1	biochemical	Havugimana PC (2012)	1
MCM2	3	HSPB1	2	affinity chromatography technology	Drissi R (2015)	1
ADRB2	0	EGLN3	0	affinity chromatography technology, pull down, pull down	Xie L (2009), Xie L (2009), Xie L (2009)	3
TOMM22	0	TOMM20	0	affinity chromatography technology, biochemical	Yano M (2000), Havugimana PC (2012)	2
PTPN5	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kurup PK (2015), Kurup PK (2015), Kurup PK (2015)	3
SDHA	2	HSPB1	2	biochemical	Wan C (2015)	1
TOMM40	1	HSP90AA1	7	pull down	Humphries AD (2005)	1
MCM2	3	HSP90AA1	7	affinity chromatography technology	Drissi R (2015)	1
CPS1	1	TOMM70	1	biochemical	Havugimana PC (2012)	1
TIMM50	4	TOMM40	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PTPN1	2	NTRK1	1	unspecified method	Espanel X (2002)	1
NTRK1	1	TBK1	1	affinity chromatography technology	Emdal KB (2015)	1
IRAK1	1	TOMM70	1	affinity chromatography technology	Li S (2011)	1
PINK1	2	PRKN	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Shiba K (2009), Shiba K (2009), Geisler S (2010), Um JW (2009), Um JW (2009), Xiong H (2009), Xiong H (2009), Xiong H (2009), Kondapalli C (2012), Kondapalli C (2012), Sha D (2010), Sha D (2010), Sha D (2010), Sha D (2010), Lazarou M (2013), Zheng X (2013), Fedorowicz MA (2014), Vives-Bauza C (2010), Shiba-Fukushima K (2014), Bertolin G (2015), Fiesel FC (2015), Kazlauskaite A (2015), Moore DJ (2006), Moore DJ (2006), Zhang T (2016), Klosowiak JL (2016), Gersch M (2017)	27
SDHA	2	TIMM50	4	biochemical	Havugimana PC (2012)	1
IRF3	4	TRAF6	0	affinity chromatography technology	Liu S (2015)	1
MAVS	1	TOMM70	1	affinity chromatography technology, affinity chromatography technology	Liu XY (2010), Liu XY (2010)	2
IRAK1	1	TIMM50	4	affinity chromatography technology	So J (2015)	1
LAMTOR3	0	TOMM40	1	biochemical	Havugimana PC (2012)	1
RIPK4	0	HSPB1	2	affinity chromatography technology	Rodriguez J (2016)	1
PRKN	1	TOMM40	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Bertolin G (2013), Bertolin G (2013)	2
SFXN1	0	TIMM50	4	biochemical	Havugimana PC (2012)	1
EGFR	5	HSPB1	2	affinity chromatography technology	Li J (2013)	1
SFXN1	0	TOMM7	0	biochemical	Havugimana PC (2012)	1
SFXN2	1	TOMM7	0	biochemical	Havugimana PC (2012)	1
EGLN3	0	TIMM50	4	affinity chromatography technology	Rodriguez J (2016)	1
EGFR	5	TBK1	1	affinity chromatography technology	Tong J (2014)	1
MCM2	3	STAU1	1	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	SFXN1	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	HNRNPM	1	affinity chromatography technology	Emdal KB (2015)	1
MCM2	3	HNRNPM	1	affinity chromatography technology	Drissi R (2015)	1
TOMM20	0	PINK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lazarou M (2012), Lazarou M (2012), Murata H (2013)	3
NTRK1	1	DHX9	3	affinity chromatography technology	Emdal KB (2015)	1
ADRB2	0	TOMM70	1	affinity chromatography technology	Roy SJ (2013)	1