PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNX3	1	MPDZ	6	affinity chromatography technology	Hein MY (2015)	1
TSC22D2	2	WNK3	2	two hybrid	Li Q (2016)	1
TSC22D2	2	ANKRD36	1	two hybrid	Li Q (2016)	1
TSC22D2	2	F8	2	two hybrid	Li Q (2016)	1
TSC22D2	2	RBL1	1	two hybrid	Li Q (2016)	1
TSC22D2	2	WDR77	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Li Q (2016), Li Q (2016), Li Q (2016)	3
RNF2	1	TTN	102	affinity chromatography technology	Cao Q (2014)	1
TSC22D2	2	SNX3	1	two hybrid	Li Q (2016)	1
TSC22D2	2	CCDC144A	2	two hybrid	Li Q (2016)	1
TSC22D2	2	SCEL	0	two hybrid	Li Q (2016)	1
TSC22D3	1	TSC22D2	2	affinity chromatography technology	Huttlin EL (2017)	1
TSC22D2	2	SAP18	1	two hybrid	Li Q (2016)	1
TSC22D2	2	FLNB	11	two hybrid	Li Q (2016)	1
TSC22D2	2	LOXHD1	10	two hybrid	Li Q (2016)	1
TSC22D3	1	NRBP1	3	affinity chromatography technology	Huttlin EL (2017)	1
TSC22D2	2	REV1	1	two hybrid	Li Q (2016)	1
TSC22D2	2	CCDC141	1	two hybrid	Li Q (2016)	1
TSC22D4	1	TSC22D3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSC22D2	2	MSH3	4	two hybrid	Li Q (2016)	1
FAM117B	3	NRBP1	3	affinity chromatography technology	Huttlin EL (2017)	1
RNF2	1	SAP18	1	affinity chromatography technology	Cao Q (2014)	1
PSMA8	2	PSMA7	1	biochemical	Havugimana PC (2012)	1
TSC22D2	2	OSBPL1A	1	two hybrid	Li Q (2016)	1
TSC22D2	2	MTIF2	4	two hybrid	Li Q (2016)	1
TSC22D2	2	EPCAM	2	two hybrid	Li Q (2016)	1
TSC22D2	2	ATP1B1	2	two hybrid	Li Q (2016)	1
TSC22D4	1	TSC22D2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSC22D2	2	GPBP1	2	two hybrid	Li Q (2016)	1
TSC22D2	2	SEC31A	7	two hybrid	Li Q (2016)	1
RNF2	1	FLNB	11	affinity chromatography technology	Cao Q (2014)	1
TSC22D2	2	SPEF2	3	two hybrid	Li Q (2016)	1
TSC22D2	2	MED13	11	two hybrid	Li Q (2016)	1
TSC22D2	2	PSMA8	2	two hybrid	Li Q (2016)	1
TSC22D2	2	ITGA2	1	two hybrid	Li Q (2016)	1
TSC22D2	2	ARID2	5	two hybrid	Li Q (2016)	1
TSC22D2	2	UFM1	0	two hybrid	Li Q (2016)	1
TSC22D2	2	CLIP1	2	two hybrid	Li Q (2016)	1
TSC22D2	2	ZNF251	1	two hybrid	Li Q (2016)	1
TSC22D2	2	ANAPC10	0	two hybrid	Li Q (2016)	1
TSC22D2	2	STK39	3	two hybrid	Li Q (2016)	1
TSC22D2	2	PRMT3	1	two hybrid	Li Q (2016)	1
TSC22D2	2	NRBP1	3	two hybrid	Li Q (2016)	1
TSC22D2	2	LRRC6	0	two hybrid	Li Q (2016)	1
NRBP1	3	TSC22D4	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
TSC22D2	2	ENOPH1	0	two hybrid	Li Q (2016)	1
TSC22D2	2	MPDZ	6	two hybrid	Li Q (2016)	1
TSC22D2	2	LPL	3	two hybrid	Li Q (2016)	1
TSC22D2	2	ZMYM2	5	two hybrid	Li Q (2016)	1
TSC22D2	2	TTN	102	two hybrid	Li Q (2016)	1
FAM117B	3	TSC22D2	2	affinity chromatography technology	Huttlin EL (2017)	1
TSC22D2	2	RNF2	1	two hybrid	Li Q (2016)	1
TSC22D4	1	STK39	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KEAP1	0	TSC22D4	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Sowa ME (2009), Hast BE (2013), Wang J (2011), Huttlin EL (2015)	4
KEAP1	0	FAM117B	3	affinity chromatography technology, two hybrid	Hast BE (2013), Rolland T (2014)	2
TSC22D2	2	NGRN	0	two hybrid	Li Q (2016)	1
FAM117B	3	TSC22D3	1	affinity chromatography technology	Huttlin EL (2017)	1
TSC22D2	2	KEAP1	0	affinity chromatography technology	Hast BE (2013)	1
TSC22D2	2	TMA7	0	two hybrid	Li Q (2016)	1
TSC22D2	2	PSMA7	1	two hybrid	Li Q (2016)	1
TSC22D4	1	WNK3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSC22D2	2	ZNF143	0	two hybrid	Li Q (2016)	1
TSC22D2	2	KIAA0586	3	two hybrid	Li Q (2016)	1