PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	AGO2	10	affinity chromatography technology	Fei T (2017)	1
CEP250	4	AGO2	10	affinity chromatography technology	Fogeron ML (2013)	1
TBK1	1	FXR2	2	affinity chromatography technology	Li S (2011)	1
OBSL1	9	MCM2	3	affinity chromatography technology	Hanson D (2014)	1
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
HNRNPL	3	LATS2	1	affinity chromatography technology	Fei T (2017)	1
TBK1	1	FMR1	1	affinity chromatography technology	Li S (2011)	1
CALCOCO2	0	RB1CC1	9	two hybrid	Wang J (2011)	1
AZI2	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Fujita F (2003), Fujita F (2003), Fujita F (2003), Fujita F (2003), Ryzhakov G (2007), Seo S (2013)	8
WHRN	1	ANKRD28	1	affinity chromatography technology	Boldt K (2016)	1
EGLN3	0	ANKRD28	1	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	TBK1	1	affinity chromatography technology	Fei T (2017)	1
ANKRD28	1	TBKBP1	2	bioid	Couzens AL (2013)	1
MCM2	3	TBK1	1	affinity chromatography technology	Drissi R (2015)	1
RB1CC1	9	TBK1	1	affinity chromatography technology, genetic interference	Behrends C (2010), Goodwin JM (2017)	2
OBSL1	9	HNRNPL	3	affinity chromatography technology	Hanson D (2014)	1
CALCOCO2	0	TBKBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Thurston TL (2009), Li S (2011), Huttlin EL (2017)	3
FXR2	2	FMR1	1	pull down, biochemical, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Siomi MC (1996), Siomi MC (1996), Ceman S (1999), Zhang Y (1995), Zhang Y (1995), Zhang Y (1995), Zhang Y (1995), Li S (2014), Li S (2014), Corominas R (2014), Rolland T (2014), Huttlin EL (2017)	12
IKBKE	2	CALCOCO2	0	affinity chromatography technology	Thurston TL (2009)	1
EGLN3	0	TBK1	1	affinity chromatography technology	Rodriguez J (2016)	1
TBKBP1	2	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Ryzhakov G (2007), Ryzhakov G (2007)	3
CEP250	4	TBKBP1	2	affinity chromatography technology	Fogeron ML (2013)	1
TBKBP1	2	AGO2	10	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TBKBP1	2	OBSL1	9	affinity chromatography technology	Li S (2011)	1
TBKBP1	2	ACAD11	0	affinity chromatography technology	Li S (2011)	1
LATS2	1	TBKBP1	2	bioid	Couzens AL (2013)	1
EGLN3	0	AZI2	1	affinity chromatography technology	Rodriguez J (2016)	1
MCM2	3	TBKBP1	2	affinity chromatography technology	Drissi R (2015)	1
TBKBP1	2	RB1CC1	9	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TBK1	1	TBKBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Li S (2011), Li S (2011), Ryzhakov G (2007), Ryzhakov G (2007), Ryzhakov G (2007), Seo S (2013), Richter B (2016)	8
WHRN	1	TBK1	1	affinity chromatography technology	Boldt K (2016)	1
LATS2	1	TBK1	1	bioid	Couzens AL (2013)	1
TBKBP1	2	APBA3	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
CALCOCO2	0	AZI2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Huttlin EL (2017)	3
AZI2	1	TBKBP1	2	affinity chromatography technology, affinity chromatography technology	Ryzhakov G (2007), Ryzhakov G (2007)	2
AZI2	1	APBA3	2	affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Li S (2011), Huttlin EL (2017)	3
TBK1	1	AGO2	10	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
HNRNPL	3	TBKBP1	2	affinity chromatography technology	Fei T (2017)	1
AZI2	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Li S (2011), Ryzhakov G (2007)	2
TBK1	1	CALCOCO2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Thurston TL (2009), Li S (2011), Li S (2011), Li S (2011), Li S (2011), Huttlin EL (2017)	6
WHRN	1	TBKBP1	2	affinity chromatography technology	Boldt K (2016)	1
MCM2	3	HNRNPL	3	affinity chromatography technology	Drissi R (2015)	1
TBKBP1	2	FXR2	2	affinity chromatography technology	Li S (2011)	1
CALCOCO2	0	FMR1	1	affinity chromatography technology	Li S (2011)	1
APBA3	2	TBK1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBKBP1	2	TBKBP1	2	affinity chromatography technology	Ryzhakov G (2007)	1
TBK1	1	ANKRD28	1	affinity chromatography technology, bioid	Bouwmeester T (2004), Couzens AL (2013)	2
TBKBP1	2	FMR1	1	affinity chromatography technology	Li S (2011)	1
EGLN3	0	APBA3	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	TBKBP1	2	affinity chromatography technology	Rodriguez J (2016)	1
FXR2	2	CALCOCO2	0	two hybrid	Rual JF (2005)	1
EGLN3	0	OBSL1	9	affinity chromatography technology	Rodriguez J (2016)	1