PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP10	1	ECE2	6	two hybrid	Wang J (2011)	1
BAG3	4	EZR	8	affinity chromatography technology	Chen Y (2013)	1
EZR	8	CASP10	1	biochemical	Gajate C (2005)	1
ECE2	6	RPS6KA2	2	affinity chromatography technology	Huttlin EL (2015)	1
PNPO	1	ECE2	6	biochemical	Wan C (2015)	1
ECE2	6	KCNIP4	0	affinity chromatography technology	Huttlin EL (2017)	1
KDM1A	2	RCOR3	0	affinity chromatography technology, two hybrid, biochemical	Bantscheff M (2011), Weimann M (2013), Wan C (2015)	3
ECE2	6	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ECE2	6	DHX40	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	ECE2	6	pull down	Nathan JA (2013)	1
ECE2	6	SYNE4	1	two hybrid	Rolland T (2014)	1
BAG3	4	ECE2	6	affinity chromatography technology	Chen Y (2013)	1
CD86	2	ECE2	6	two hybrid	Wang J (2011)	1
MTNR1A	1	ECE2	6	two hybrid	Benleulmi-Chaachoua A (2016)	1
ECE2	6	RCOR1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
ECE2	6	KDM1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EZR	8	ECE2	6	biochemical	Wan C (2015)	1
CMPK1	2	ECE2	6	biochemical	Wan C (2015)	1