PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UVRAG	2	PIK3R4	3	affinity chromatography technology	Behrends C (2010)	1
BECN1	2	EXOC2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Simicek M (2013), Simicek M (2013), Bodemann BO (2011)	3
UVRAG	2	RUBCN	3	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Matsunaga K (2009)	2
RUBCN	3	PIK3R4	3	affinity chromatography technology	Matsunaga K (2009)	1
EXOC1	3	EXOC2	5	biochemical, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Huttlin EL (2017), Boldt K (2016)	3
EXOC1	3	RUBCN	3	two hybrid, affinity chromatography technology	Bodemann BO (2011), Bodemann BO (2011)	2
BECN1	2	RUBCN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Ma B (2014), Hein MY (2015), Chauhan S (2015), Lei Y (2016)	8
EXOC8	1	RUBCN	3	affinity chromatography technology	Bodemann BO (2011)	1
BECN1	2	PIK3C3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Platta HW (2012), Platta HW (2012), Platta HW (2012), Wang J (2008), Xia P (2013), Luciani A (2010), Luciani A (2010), Matsunaga K (2009), Ma B (2014), Xia P (2014), Itakura E (2008), Itakura E (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Pattingre S (2005), Luo S (2010), Ramachandran N (2013), Fogel AI (2013), Xu D (2015), Hein MY (2015), Ma B (2015), Zeng X (2006), Verma N (2017), Wei Y (2015), Stjepanovic G (2017), Liu X (2017), Li X (2017)	30
EXOC8	1	BECN1	2	affinity chromatography technology, affinity chromatography technology	Bodemann BO (2011), Bodemann BO (2011)	2
EXOC2	5	RUBCN	3	affinity chromatography technology	Bodemann BO (2011)	1
EXOC8	1	EXOC1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
EXOC8	1	EXOC2	5	two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Moskalenko S (2003), Moskalenko S (2003), Moskalenko S (2003), Havugimana PC (2012), Simicek M (2013), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	8
PIK3C3	1	PIK3R4	3	affinity chromatography technology, biochemical, pull down	Behrends C (2010), Wan C (2015), Stjepanovic G (2017)	3
EXOC8	1	PIK3C3	1	affinity chromatography technology	Bodemann BO (2011)	1
YWHAE	0	RUBCN	3	affinity chromatography technology	Choudhary C (2009)	1
PIK3C3	1	RUBCN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Matsunaga K (2009), Ma B (2014)	3
YWHAE	0	UVRAG	2	affinity chromatography technology	Choudhary C (2009)	1
EXOC2	5	PIK3C3	1	affinity chromatography technology	Bodemann BO (2011)	1
YWHAE	0	PIK3R4	3	affinity chromatography technology	Choudhary C (2009)	1
BECN1	2	UVRAG	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Noble CG (2008), Itakura E (2008), Itakura E (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Fogel AI (2013), Hein MY (2015), Yang Y (2016)	16
PIK3C3	1	UVRAG	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Ma B (2014), Itakura E (2008), Itakura E (2008)	5
BECN1	2	PIK3R4	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Luciani A (2010), Luciani A (2010), Matsunaga K (2009), Sun Q (2008), Fogel AI (2013), Hein MY (2015)	7