PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PSMC5	4	UBE3C	5	affinity chromatography technology, pull down	You J (2003), You J (2001)	2
USP13	2	UBC	7	enzymatic study, pull down, pull down, pull down, pull down	Zhang YH (2012), Nathan JA (2013), Zhang YH (2012), Zhang X (2017), Kwasna D (2018)	5
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
ANXA7	0	PCBP1	2	biochemical	Wan C (2015)	1
EEF2K	3	PANK4	3	biochemical	Kristensen AR (2012)	1
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
PSMD6	0	PSMC5	4	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
KDM1A	2	MTA1	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wang Y (2009), Wang Y (2009), Cui S (2011), Cui S (2011)	4
SEM1	0	PSMD2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baillat D (2005), Wei SJ (2008), Krogan NJ (2004), Krogan NJ (2004)	4
PSMD2	2	UBE2L3	1	biochemical	Havugimana PC (2012)	1
HNRNPL	3	PANK4	3	affinity chromatography technology	Fei T (2017)	1
CCNB1	3	UBE3C	5	pull down, enzymatic study	Okada M (2015), Okada M (2015)	2
TRIM25	5	MYC	2	affinity chromatography technology	Choudhury NR (2017)	1
FAM3C	0	UBE3C	5	affinity chromatography technology	Sun Y (2017)	1
RAD21	3	UBE3C	5	affinity chromatography technology	Panigrahi AK (2011)	1
TRIM25	5	FAF2	4	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	PCBP1	2	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
WDR92	2	UBE3C	5	biochemical	Kristensen AR (2012)	1
PSMC5	4	PSMD14	3	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Braunstein I (2015), Huttlin EL (2017)	7
CFTR	5	PSMA2	1	affinity chromatography technology	Pankow S (2015)	1
SEM1	0	PSMD6	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wei SJ (2008), Wei SJ (2008), Gudmundsdottir K (2007), Gudmundsdottir K (2007), Zhang Y (2014)	5
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CFTR	5	PSMD14	3	affinity chromatography technology	Pankow S (2015)	1
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
PSMA2	1	PSMD2	2	affinity chromatography technology, biochemical, biochemical	Bousquet-Dubouch MP (2009), Havugimana PC (2012), Wan C (2015)	3
HNRNPL	3	TLK1	5	affinity chromatography technology	Fei T (2017)	1
FAF2	4	PSMD2	2	affinity chromatography technology, pull down	Suzuki M (2012), Suzuki M (2012)	2
PSMD14	3	PSMD2	2	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Sun S (2017)	6
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
PHKA2	6	UBE3C	5	biochemical	Havugimana PC (2012)	1
UBC	7	FAF2	4	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Alexandru G (2008)	2
RAD21	3	USP13	2	affinity chromatography technology	Huttlin EL (2017)	1
PSMD6	0	PSMA2	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Bousquet-Dubouch MP (2009), Havugimana PC (2012), Wan C (2015)	4
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
NTRK1	1	KDM1A	2	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	PSMD6	0	pull down	Zhang X (2017)	1
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
SCN2B	1	CAND2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	PSMD2	2	affinity chromatography technology	Emdal KB (2015)	1
RAD21	3	PSMD2	2	affinity chromatography technology	Panigrahi AK (2011)	1
ELAVL1	0	MTA1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
VSIG4	1	APP	1	pull down	Olah J (2011)	1
SCN2B	1	UBE3C	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
FAF2	4	UBE3C	5	affinity chromatography technology	Raman M (2015)	1
UBE2D1	0	CAND2	7	biochemical	You J (2001)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
USP13	2	FAF2	4	affinity chromatography technology	Sowa ME (2009)	1
GOLGA2	2	UBE3C	5	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
UBE3C	5	UBE2D1	0	pull down, pull down, pull down, biochemical, biochemical, pull down, pull down	You J (2003), Wang M (2006), Schwarz SE (1998), Havugimana PC (2012), You J (2001), You J (2001), Kristariyanto YA (2015)	7
UBC	7	PSMD14	3	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
MYC	2	RAD21	3	genetic interference	Toyoshima M (2012)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
NTRK1	1	RAD21	3	affinity chromatography technology	Emdal KB (2015)	1
PCBP1	2	UBE3C	5	affinity chromatography technology	Zhang MP (2017)	1
RIPK4	0	ECT2	2	affinity chromatography technology	Rodriguez J (2016)	1
UBE2D2	0	CCNB1	3	enzymatic study	Tang Z (2001)	1
UBE3C	5	APP	1	pull down	Olah J (2011)	1
UBE3C	5	UBE2D2	0	pull down, pull down	Wu PY (2003), Kristariyanto YA (2015)	2
NTRK1	1	UBE3C	5	affinity chromatography technology	Emdal KB (2015)	1
ELAVL1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, pull down	Abdelmohsen K (2009), Zhou HL (2013), Zhou HL (2013)	3
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
APP	1	MYC	2	pull down	Virok DP (2011)	1
GOLGA2	2	KDM1A	2	two hybrid	Rolland T (2014)	1
ANXA7	0	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
TRIM25	5	MTA1	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Zang HL (2017)	2
CFTR	5	PSMC5	4	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	PSMD2	2	affinity chromatography technology	Wang X (2006)	1
ELAVL1	0	TLK1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
PANK4	3	UBE3C	5	biochemical	Kristensen AR (2012)	1
SEM1	0	PSMA2	1	affinity chromatography technology	Wei SJ (2008)	1
MYC	2	NTRK1	1	genetic interference	Toyoshima M (2012)	1
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
MYC	2	RBM15	7	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	UBE2L3	1	affinity chromatography technology	Choudhury NR (2017)	1
PSMD14	3	UBE3C	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang X (2007), Jacobson AD (2014), Jacobson AD (2014)	3
SEM1	0	PSMC5	4	affinity chromatography technology, affinity chromatography technology	Baillat D (2005), Krogan NJ (2004)	2
PSMA2	1	PSMC5	4	affinity chromatography technology, biochemical	Bousquet-Dubouch MP (2009), Wan C (2015)	2
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	UTRN	6	affinity chromatography technology	Fei T (2017)	1
MTA2	1	UBE3C	5	two hybrid	Wang J (2011)	1
PSMA2	1	UBE3C	5	affinity chromatography technology	Bousquet-Dubouch MP (2009)	1
PSMD6	0	PSMD14	3	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015)	7
ESR1	0	PSMC5	4	pull down	vom Baur E (1996)	1
ESR1	0	UBE3C	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okada M (2015), Okada M (2015), Okada M (2015)	3
SEM1	0	PSMD14	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baillat D (2005), Wei SJ (2008), Wei SJ (2008), Wang X (2007)	4
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
MYC	2	UBE2L3	1	affinity chromatography technology	Shimura H (2001)	1
TRIM25	5	UBE3C	5	affinity chromatography technology	Choudhury NR (2017)	1
PSMA2	1	PSMD14	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Bousquet-Dubouch MP (2009), Wang X (2007), Wan C (2015), Sparks A (2014)	4
CPEB4	2	UBE3C	5	biochemical	Havugimana PC (2012)	1
ECT2	2	KDM1A	2	affinity chromatography technology	Woods NT (2012)	1
ELAVL1	0	MTA2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE3C	5	UBE2D3	1	pull down, pull down	Kristariyanto YA (2015), Okada M (2015)	2
RAD21	3	UBC	7	affinity chromatography technology	Panigrahi AK (2011)	1
UBE3C	5	UBE3C	5	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Schwarz SE (1998), Sheng Y (2012), You J (2001), Zhang W (2016), Byrne R (2017)	5
THOC2	4	UTRN	6	biochemical	Havugimana PC (2012)	1
ELAVL1	0	EEF2K	3	affinity chromatography technology	Abdelmohsen K (2009)	1
MTA2	1	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Cui S (2011), Wan C (2015)	4
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
MTA2	1	KDM1A	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wang Y (2009), Wang Y (2009), Wang Y (2009), Li Q (2011), Cui S (2011)	5
TLK1	5	UBE3C	5	two hybrid	Wang J (2011)	1
SEM1	0	UBC	7	affinity chromatography technology	Besche HC (2014)	1
PSMD2	2	UBE3C	5	pull down, affinity chromatography technology, pull down	You J (2003), Chu BW (2013), You J (2001)	3
UBE3C	5	WDR74	0	biochemical	Havugimana PC (2012)	1
MYC	2	PSMD2	2	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
PCBP1	2	TRIM25	5	affinity chromatography technology	Zhang MP (2017)	1
UBE3C	5	UBE2L3	1	pull down, pull down, pull down, pull down	Schwarz SE (1998), Michel MA (2015), Kristariyanto YA (2015), Zhang W (2016)	4
ESR1	0	GOLGA2	2	affinity chromatography technology	Tarallo R (2011)	1
ECT2	2	UBE3C	5	affinity chromatography technology	Woods NT (2012)	1
MYC	2	UBE3C	5	affinity chromatography technology	Koch HB (2007)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
MYC	2	PSMA2	1	affinity chromatography technology	Koch HB (2007)	1
MTA1	3	ESR1	0	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Kumar R (2002), Kumar R (2002), Kumar R (2002), Mazumdar A (2001), Singh RR (2006), Mishra SK (2003)	6
EFNB2	0	CAND2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
THOC7	0	USP13	2	biochemical	Havugimana PC (2012)	1
RBM15	7	UBE3C	5	biochemical	Havugimana PC (2012)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	PSMA2	1	affinity chromatography technology	Emdal KB (2015)	1
VSIG4	1	UBE3C	5	affinity chromatography technology	Huttlin EL (2015)	1
UBE2D1	0	UTRN	6	biochemical	Havugimana PC (2012)	1
THOC2	4	UBE3C	5	biochemical	Havugimana PC (2012)	1
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	PSMC5	4	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PSMD14	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	MTA1	3	affinity chromatography technology	Emdal KB (2015)	1
UBE3C	5	CAND2	7	enzymatic study	You J (2003)	1
NTRK1	1	MTA2	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	GOLGA2	2	affinity chromatography technology	Emdal KB (2015)	1
FAM234B	0	UBE3C	5	affinity chromatography technology	Huttlin EL (2017)	1
PSMD6	0	UBE3C	5	affinity chromatography technology	You J (2003)	1
HNRNPL	3	ANXA7	0	affinity chromatography technology	Fei T (2017)	1
UBE3C	5	UTRN	6	biochemical	Havugimana PC (2012)	1
FAF2	4	UBE2D1	0	pull down	Phan VT (2010)	1
PCBP1	2	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	UBE2L3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MYC	2	PCBP1	2	affinity chromatography technology	Koch HB (2007)	1
PSMC5	4	MYC	2	affinity chromatography technology	von der Lehr N (2003)	1
EFNB2	0	UBE3C	5	affinity chromatography technology	Huttlin EL (2015)	1
CFTR	5	FAF2	4	affinity chromatography technology	Pankow S (2015)	1
NTRK1	1	THOC2	4	affinity chromatography technology	Emdal KB (2015)	1
ELAVL1	0	RBM15	7	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	PSMC5	4	affinity chromatography technology	Choudhury NR (2017)	1
MTA2	1	ESR1	0	pull down, pull down, affinity chromatography technology	Cui Y (2006), Cui Y (2006), Cui Y (2006)	3
RIPK4	0	UBE3C	5	affinity chromatography technology	Rodriguez J (2016)	1
EEF2K	3	UBE3C	5	biochemical	Kristensen AR (2012)	1
SEM1	0	UBE3C	5	affinity chromatography technology, affinity chromatography technology	Besche HC (2014), Besche HC (2014)	2
KDM1A	2	UBE3C	5	biochemical	Havugimana PC (2012)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE3C	5	ANXA7	0	affinity chromatography technology, affinity chromatography technology	Pan SJ (2015), Pan SJ (2015)	2
NTRK1	1	PANK4	3	affinity chromatography technology	Emdal KB (2015)	1
THOC2	4	THOC7	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Masuda S (2005), Havugimana PC (2012), Chi B (2013), Wan C (2015), Hein MY (2015), Hein MY (2015)	6
HNRNPL	3	EFNB2	0	affinity chromatography technology	Fei T (2017)	1
TRIM25	5	PSMD2	2	affinity chromatography technology	Choudhury NR (2017)	1
MYC	2	KDM1A	2	two hybrid	Weimann M (2013)	1
ESR1	0	KDM1A	2	affinity chromatography technology, affinity chromatography technology	Garcia-Bassets I (2007), Garcia-Bassets I (2007)	2
THOC7	0	UBE3C	5	biochemical	Havugimana PC (2012)	1
PSMC5	4	PSMD2	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
NTRK1	1	RBM15	7	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
UBE3C	5	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Wang M (2006), Wu PY (2003), Michel MA (2015), Kristariyanto YA (2015), Okada M (2015)	5
ELAVL1	0	PCBP1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	PSMA2	1	affinity chromatography technology	Matsumoto M (2005)	1
PSMD6	0	PSMD2	2	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
RIPK4	0	FAF2	4	affinity chromatography technology	Rodriguez J (2016)	1
CFTR	5	UBE3C	5	affinity chromatography technology	Pankow S (2015)	1
HNRNPL	3	UBE3C	5	affinity chromatography technology	Fei T (2017)	1
ELAVL1	0	ANXA7	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE3C	5	USP13	2	biochemical	Havugimana PC (2012)	1
MTA1	3	UBE3C	5	affinity chromatography technology	Zang HL (2017)	1
ELAVL1	0	UBE3C	5	affinity chromatography technology	Abdelmohsen K (2009)	1
NTRK1	1	PSMD6	0	affinity chromatography technology	Emdal KB (2015)	1