PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIST1H4A	0	CUL1	7	biochemical	Kristensen AR (2012)	1
KDM4A	3	AR	3	affinity chromatography technology	Shin S (2007)	1
NXF1	0	CAPZA1	2	affinity chromatography technology	Castello A (2012)	1
PRMT5	3	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Pal S (2003), Amente S (2005), Pal S (2004), Migliori V (2012)	4
H3F3A	1	KDM4C	2	affinity chromatography technology	Heo K (2007)	1
WAS	0	KDM4A	3	affinity chromatography technology	Taylor MD (2010)	1
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
KDM4A	3	HDAC1	4	affinity chromatography technology	Gray SG (2005)	1
KDM4A	3	FBXL4	1	affinity chromatography technology, affinity chromatography technology	Van Rechem C (2011), Van Rechem C (2011)	2
KDM4C	2	HIST1H3A	3	enzymatic study	Cloos PA (2006)	1
HDAC3	5	HIST1H4A	0	enzymatic study, pull down	Hartman HB (2005), Li X (2014)	2
RB1	2	AR	3	pull down, pull down, two hybrid, affinity chromatography technology	Lu J (1998), Yeh S (1998), Yeh S (1998), Gamble SC (2007)	4
HIST1H4A	0	HDAC1	4	pull down, pull down, affinity chromatography technology	Shiio Y (2003), Li X (2014), Hein MY (2015)	3
EPHB2	10	KDM4A	3	biochemical	Wan C (2015)	1
KDM4C	2	HDAC3	5	affinity chromatography technology	Lizcano F (2011)	1
KDM4A	3	CUL1	7	affinity chromatography technology	Van Rechem C (2011)	1
ZNF414	1	KDM4A	3	affinity chromatography technology	Huttlin EL (2017)	1
RNF8	2	KDM4A	3	enzymatic study	Mallette FA (2012)	1
ABHD5	2	KDM4A	3	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3A	3	NCOR1	9	pull down	Yu J (2003)	1
KDM4A	3	HIST1H4A	0	unspecified method	Botuyan MV (2006)	1
NCOR1	9	HIST1H4A	0	pull down	Hartman HB (2005)	1
CUL1	7	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
RNF168	0	KDM4A	3	enzymatic study	Mallette FA (2012)	1
AR	3	NCOR1	9	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, imaging technique, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Masiello D (2004), Song LN (2004), Cheng S (2002), Cheng S (2002), Cheng S (2002), Hodgson MC (2005), Hodgson MC (2005), Cheng S (2002), Cheng S (2002), Song LN (2004), Wu Y (2006), Wu Y (2006), Fu M (2002), Altintas DM (2011), Cui J (2011), Hodgson MC (2005), Hodgson MC (2005), Zhu P (2006), Qi J (2013), Lempiaeinen JK (2017), Tan G (2017)	21
KDM4C	2	PRMT5	3	genetic interference	Wong AS (2016)	1
RB1	2	HDAC1	4	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Dick FA (2000), Fuks F (2000), Puri PL (2001), Puri PL (2001), Wang S (2002), Luo RX (1998), Luo RX (1998), Lai A (1999), Lai A (1999), Ferreira R (1998), Kimura H (2003), Qiu Z (2008), Fedele M (2006), Brown VD (2002), Khan MM (2001), Dasgupta P (2004), Chang YC (2001), Dahiya A (2000), Zhang HS (2000), Tokitou F (1999), Nguyen DX (2004), Takaki T (2004), Magnaghi-Jaulin L (1998), Magnaghi-Jaulin L (1998), Brehm A (1998), Brehm A (1998), Brehm A (1998), Sun JM (2007), Fan LX (2012), Harbour JW (1999), Brehm A (1999), Joshi P (2013), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	36
HDAC1	4	H3F3A	1	affinity chromatography technology	Hein MY (2015)	1
PRMT5	3	HIST1H4A	0	enzymatic study, enzymatic study, enzymatic study	Pal S (2003), Amente S (2005), Pal S (2004)	3
NXF1	0	KDM4C	2	affinity chromatography technology	Castello A (2012)	1
AR	3	HDAC3	5	pull down, affinity chromatography technology	Franco PJ (2003), Zhu P (2006)	2
KDM4C	2	KDM4A	3	affinity chromatography technology, affinity chromatography technology	Shin S (2007), Shin S (2007)	2
NXF1	0	KDM4A	3	affinity chromatography technology	Castello A (2012)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
NCOR1	9	KDM4A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, imaging technique	Yoon HG (2003), Zhang D (2005), Zhang D (2005), Zhang D (2005), Zhang D (2005), Zhang D (2005)	6
WDR48	2	KDM4A	3	affinity chromatography technology	Sowa ME (2009)	1
WDR48	2	STK11	2	affinity chromatography technology	Sowa ME (2009)	1
STK11	2	KDM4A	3	affinity chromatography technology	Huttlin EL (2017)	1
KDM4A	3	HDAC3	5	affinity chromatography technology	Gray SG (2005)	1
MOV10	6	KDM4C	2	affinity chromatography technology	Castello A (2012)	1
HDAC3	5	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fajas L (2002), Lai A (1999), Lai A (1999), Dahiya A (2000)	4
KDM4A	3	HIST1H3A	3	enzymatic study, x-ray crystallography, unspecified method	Klose RJ (2006), Huang Y (2006), Huang Y (2006)	3
KDM4B	6	KDM4A	3	affinity chromatography technology	Huttlin EL (2017)	1
ZNF414	1	KDM4B	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H3F3A	1	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology	Tagami H (2004), Lacoste N (2014)	2
MOV10	6	KDM4A	3	affinity chromatography technology	Castello A (2012)	1
AR	3	WDR48	2	affinity chromatography technology	McClurg UL (2015)	1
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
KDM4A	3	KDM4A	3	affinity chromatography technology	Shin S (2007)	1
CCL22	1	KDM4A	3	affinity chromatography technology	Huttlin EL (2017)	1
KDM4A	3	H3F3A	1	x-ray crystallography	Ulucan O (2011)	1
KDM4A	3	RB1	2	affinity chromatography technology, two hybrid	Gray SG (2005), Gray SG (2005)	2
KDM4A	3	CAPZA1	2	biochemical	Wan C (2015)	1
ZNF131	0	KDM4A	3	affinity chromatography technology	Varier RA (2016)	1
HIST1H3A	3	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Nishioka K (2002), Li X (2014), Hein MY (2015)	3
PRMT5	3	HDAC1	4	genetic interference	Wong AS (2016)	1
KDM4A	3	PRMT5	3	genetic interference	Wong AS (2016)	1
KDM4C	2	HDAC1	4	affinity chromatography technology	Lizcano F (2011)	1
HIST1H3A	3	HDAC3	5	pull down	Li X (2014)	1