PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PAN2	3	CD59	2	affinity chromatography technology	Bett JS (2013)	1
CFTR	5	DBN1	1	affinity chromatography technology	Pankow S (2015)	1
PAN2	3	FLNA	10	affinity chromatography technology	Bett JS (2013)	1
FLNA	10	CD59	2	affinity chromatography technology	Hein MY (2015)	1
DBN1	1	CD59	2	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
ABCE1	2	CD59	2	affinity chromatography technology	Kaerblane K (2015)	1
ABCE1	2	FLNA	10	affinity chromatography technology	Kaerblane K (2015)	1
GOLT1B	0	CD59	2	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	FLNA	10	affinity chromatography technology	Bisson N (2011)	1
MAPRE1	0	DBN1	1	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	CD59	2	fluorescent resonance energy transfe	Blagoev B (2003)	1
SYNPO	5	FLNA	10	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
TINAGL1	0	CD59	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DBN1	1	FLNA	10	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015), Hein MY (2015)	3
MAPRE1	0	CD59	2	affinity chromatography technology	Hein MY (2015)	1
SMAD4	9	CD59	2	two hybrid	Colland F (2004)	1
NCR3	0	CD59	2	affinity chromatography technology	Marcenaro E (2003)	1
MAPRE1	0	SYNPO	5	affinity chromatography technology	Hein MY (2015)	1
UBE2A	0	CD59	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), An H (2017)	2
GRB2	2	DBN1	1	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
CD59	2	C9	2	pull down, pull down	Chang CP (1994), Ninomiya H (1992)	2
IGFBP1	0	CD59	2	affinity chromatography technology	Huttlin EL (2017)	1
MAPRE1	0	FLNA	10	affinity chromatography technology	Hein MY (2015)	1
ATP6AP2	2	CD59	2	affinity chromatography technology	Hein MY (2015)	1
GALK2	3	CD59	2	affinity chromatography technology	Huttlin EL (2017)	1
NCR1	1	CD59	2	affinity chromatography technology	Marcenaro E (2003)	1
ABCE1	2	MAPRE1	0	affinity chromatography technology	Kaerblane K (2015)	1
CFTR	5	CD59	2	affinity chromatography technology	Wang X (2006)	1
CD27	1	CD59	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SYNPO	5	CD59	2	affinity chromatography technology	Hein MY (2015)	1
PAN2	3	DBN1	1	affinity chromatography technology	Bett JS (2013)	1
GRB2	2	CD59	2	affinity chromatography technology	Blagoev B (2003)	1
SYNPO	5	DBN1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
C8A	2	CD59	2	pull down	Lockert DH (1995)	1
CD8A	0	CD59	2	pull down	Ninomiya H (1992)	1
TMPRSS11B	0	CD59	2	affinity chromatography technology	Huttlin EL (2017)	1