PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZBP1	2	CTBP1	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
KDM1A	2	CTBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi YJ (2005), Lee MG (2005), Kuppuswamy M (2008), Kuppuswamy M (2008), Keutgens A (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
HDAC1	4	HIST3H3	0	enzymatic study, unspecified method	Shi Y (2003), Vermeulen M (2010)	2
LCOR	4	ZNF516	8	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	ZNF516	8	affinity chromatography technology	Yao Z (2017)	1
MED23	3	CTBP1	2	affinity chromatography technology	Lambert JP (2015)	1
EGFR	5	HDAC1	4	affinity chromatography technology	Yao Z (2017)	1
HDAC1	4	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2003), You A (2001), You A (2001), Shi YJ (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Godmann M (2007), Terhune SS (2010), Godmann M (2010), Godmann M (2010), Wang Y (2009), Nicholson TB (2011), Li Q (2011), Cui S (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Wang Q (2016), Huttlin EL (2017)	26
DYRK1B	1	ZNF516	8	affinity chromatography technology	Varjosalo M (2013)	1
ZBP1	2	KDM1A	2	affinity chromatography technology	Li S (2011)	1
ZBTB42	0	ZNF516	8	affinity chromatography technology	Huttlin EL (2017)	1
LCOR	4	HDAC1	4	pull down	Fernandes I (2003)	1
ZBP1	2	ZNF516	8	affinity chromatography technology	Li S (2011)	1
EGFR	5	CTBP1	2	affinity chromatography technology	Tong J (2014)	1
HDAC1	4	ZNF516	8	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2017)	2
KDM1A	2	ZNF516	8	affinity chromatography technology	Lee MG (2005)	1
MED23	3	ZNF516	8	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
HDAC1	4	CTBP1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang CL (2001), Melhuish TA (2000), Sundqvist A (1998), Jin W (2008), Joshi P (2013)	5
ZNF516	8	HIST3H3	0	enzymatic study	Shi Y (2003)	1
HYPK	2	ZNF516	8	affinity chromatography technology	Choudhury KR (2012)	1
CTBP1	2	HIST3H3	0	enzymatic study	Shi Y (2003)	1
MED23	3	DYRK1B	1	affinity chromatography technology	Lambert JP (2015)	1
MED23	3	KDM1A	2	affinity chromatography technology	Lambert JP (2015)	1
CTBP1	2	LCOR	4	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ravasi T (2010), Fernandes I (2003), Fernandes I (2003), Corominas R (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	7
CTBP1	2	ZNF516	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2