PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SOCS5	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CASP3	0	SOCS5	0	two hybrid	Wang J (2011)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
SOCS5	0	TMBIM1	1	two hybrid	Wang J (2011)	1
DCUN1D1	0	SOCS5	0	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	TMBIM1	1	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	SOCS5	0	affinity chromatography technology	Kario E (2005)	1
CASP3	0	APP	1	imaging technique	Chen TC (2014)	1
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
CUL5	1	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Zhang X (2017)	2
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
TRIM25	5	CUL5	1	affinity chromatography technology	Choudhury NR (2017)	1
DCUN1D1	0	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Huang G (2014), Huang G (2014)	3
CUL5	1	SOCS5	0	affinity chromatography technology	Huttlin EL (2017)	1
ALK	8	SOCS5	0	affinity chromatography technology	Crockett DK (2004)	1
IL4R	1	SOCS5	0	affinity chromatography technology, pull down	Seki Y (2002), Seki Y (2002)	2
UBC	7	SOCS5	0	pull down	Nathan JA (2013)	1
TRIM25	5	SOCS5	0	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1