PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CLTC	12	CCT6A	1	biochemical	Wan C (2015)	1
VCP	6	RUVBL2	4	affinity chromatography technology	Fogeron ML (2013)	1
ESR1	0	EPRS	2	pull down	Nalvarte I (2010)	1
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
TRAF6	0	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Ling L (2000), Ling L (2000), Ling L (2000), Wang J (2011)	4
TRAF6	0	DDX3X	52	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Yu J (2016)	2
TCP1	0	CCT2	1	affinity chromatography technology, biochemical, biochemical, biochemical, biochemical	Gingras AC (2005), Imai Y (2003), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
FKBP5	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TNIP1	1	TBK1	1	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
TRAF2	1	TRAF3IP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Qian Y (2004), Sun D (2011)	3
UBC	7	CCT8	0	affinity chromatography technology	Bish RA (2007)	1
IKBKB	1	CLTC	12	imaging technique	Chen TC (2014)	1
TMEM173	0	IKBKE	2	affinity chromatography technology	Zhang Q (2017)	1
TRAF2	1	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
HSP90AA1	7	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
ESR1	0	VCP	6	pull down	Nalvarte I (2010)	1
UBC	7	CCT5	1	affinity chromatography technology	Matsumoto M (2005)	1
TRAF3IP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Liu C (2009), Kanamori M (2002), Kanamori M (2002), Kanamori M (2002), Qian Y (2007), Qu F (2012), Wu NL (2014), Wu NL (2014), Rolland T (2014), Garg AV (2013), Sun D (2011), Yu H (2011)	12
IKBKE	2	EPRS	2	affinity chromatography technology	Ewing RM (2007)	1
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
NFKBIA	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2015)	1
MAVS	1	PSMA7	1	affinity chromatography technology, affinity chromatography technology	Jia Y (2009), Jia Y (2009)	2
IKBKG	0	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Stempin CC (2011), Pringle LM (2011), Wu CJ (2006), Higashimoto T (2008), Ducut Sigala JL (2004), Shibata Y (2011), Liu L (2002), Xiao G (2000), Chan H (2005), Funakoshi-Tago M (2005), Wu X (2007), Kato T (2008), Niu J (2011), Neumann M (2011), Keusekotten K (2013), Fu J (2013), Dan HC (2008), Criollo A (2010), Hein MY (2015), Baratchian M (2016)	20
IKBKE	2	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Rajsbaum R (2014), Paz S (2009), Bharaj P (2016)	3
MAVS	1	BIRC3	1	affinity chromatography technology	Mao AP (2010)	1
ESR1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Wang C (2015), Wang C (2015)	2
IKBKE	2	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ng MH (2011), Charoenthongtrakul S (2013), Peng Y (2014), Gu L (2017), Fang R (2017)	5
CCT2	1	CCT3	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
TANK	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Goncharov T (2013)	2
TBK1	1	CYLD	2	affinity chromatography technology, imaging technique, affinity chromatography technology	Friedman CS (2008), Genin P (2015), Genin P (2015)	3
RNF11	0	IKBKG	0	two hybrid	Colland F (2004)	1
RNF11	0	CALCOCO2	0	two hybrid	Colland F (2004)	1
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
CYLD	2	CCT3	1	affinity chromatography technology	Elliott PR (2016)	1
TBK1	1	XIAP	0	enzymatic study, enzymatic study	Nakhaei P (2012), Kuranaga E (2006)	2
ESR1	0	TRAF6	0	affinity chromatography technology	Robinson LJ (2009)	1
IKBKE	2	IRF3	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Friedman CS (2008), Nakhaei P (2012), Bharaj P (2016), Zhang Q (2017)	4
IKBKE	2	BIRC2	1	affinity chromatography technology, enzymatic study	Zhou AY (2013), Zhou AY (2013)	2
IKBKE	2	CCT8	0	affinity chromatography technology	So J (2015)	1
IKBKE	2	TANK	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nomura F (2000), Nomura F (2000), Nomura F (2000), Gatot JS (2007), Renner F (2011), Shen RR (2012), Ryzhakov G (2007), So J (2015)	8
CYLD	2	CCT2	1	affinity chromatography technology	Elliott PR (2016)	1
IRF3	4	TRAF2	1	affinity chromatography technology	Liu S (2015)	1
TRIM6	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Rajsbaum R (2014), Rajsbaum R (2014)	2
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
TRAF3IP2	0	IRF3	4	affinity chromatography technology	Ryzhakov G (2012)	1
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
IKBKE	2	LRPPRC	7	affinity chromatography technology	Ewing RM (2007)	1
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
DDX58	3	CYLD	2	affinity chromatography technology	Friedman CS (2008)	1
TRAF3IP2	0	UBC	7	enzymatic study	Liu C (2009)	1
TBK1	1	NFKBIA	0	enzymatic study	Zhang W (2010)	1
IKBKE	2	TRAF2	1	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Shen RR (2012), Shen RR (2012), Shen RR (2012), Zhang W (2010), Zhou AY (2013), Zhou AY (2013), So J (2015), Fang R (2017)	8
TRIM27	2	TBK1	1	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
CLTC	12	PPP2R1A	8	biochemical	Wan C (2015)	1
IKBKE	2	CCT5	1	affinity chromatography technology	So J (2015)	1
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
TANK	1	CHUK	5	affinity chromatography technology	Chariot A (2002)	1
TCP1	0	CCT4	2	affinity chromatography technology, biochemical, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
CYLD	2	DDX3X	52	affinity chromatography technology	Elliott PR (2016)	1
IKBKE	2	IKBKE	2	affinity chromatography technology	Zhou AY (2013)	1
TRIM27	2	IKBKE	2	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
IKBKE	2	FKBP5	0	affinity chromatography technology	Bouwmeester T (2004)	1
DDX58	3	IRF3	4	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Xu LG (2005)	2
IKBKG	0	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Leonardi A (2000), Li X (2000), Mauro C (2003), Mauro C (2003), Mauro C (2003)	5
IKBKE	2	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Qu F (2012), Qu F (2012), Qu F (2012), Ryzhakov G (2012)	4
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
VCP	6	TAX1BP1	3	affinity chromatography technology	Yu CC (2013)	1
IKBKG	0	TRAF3	1	affinity chromatography technology	Belgnaoui SM (2012)	1
CCT8	0	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
IKBKB	1	MAVS	1	enzymatic study	Liu S (2015)	1
HSP90AA1	7	IKBKE	2	affinity chromatography technology	Taipale M (2012)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
AZI2	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Fujita F (2003), Fujita F (2003), Fujita F (2003), Fujita F (2003), Ryzhakov G (2007), Seo S (2013)	8
TRAF3	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakhaei P (2009), Arnaud N (2011), Paz S (2011), Wang Y (2012), Saha SK (2006), Saha SK (2006), Ng MH (2011), Johnsen IB (2009), van Zuylen WJ (2012), Belgnaoui SM (2012), Chen X (2014), Wang P (2013), Wang P (2013), Minassian A (2015), Gu L (2017), Khan M (2016), Fang R (2017), Fang R (2017)	18
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
IKBKE	2	CDC37	0	affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Li S (2011)	2
MAVS	1	IFIT3	1	affinity chromatography technology, affinity chromatography technology	Liu XY (2011), Liu XY (2011)	2
ESR1	0	SND1	4	pull down	Nalvarte I (2010)	1
TOPORS	6	UBC	7	enzymatic study	Rajendra R (2004)	1
DDX58	3	IKBKG	0	affinity chromatography technology	Oshiumi H (2013)	1
IRF3	4	HSP90AA1	7	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Yang K (2006), Yang K (2006), Yang K (2006), Liu XY (2010), Liu XY (2010)	5
TRAF3	1	TNIP1	1	affinity chromatography technology	Gao L (2011)	1
RELA	1	UBC	7	affinity chromatography technology	Schweitzer K (2015)	1
TBK1	1	IFIT3	1	affinity chromatography technology, affinity chromatography technology	Liu XY (2011), Liu XY (2011)	2
MYD88	1	TNIP1	1	affinity chromatography technology, affinity chromatography technology	Zhou J (2011), Zhou J (2011)	2
YAP1	0	DDX3X	52	affinity chromatography technology	Enzo E (2015)	1
ESR1	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Lee MO (2002), Fan M (2005), Tateishi Y (2004), Fiskus W (2007), Powell E (2010), Suzuki T (2011), Berry NB (2008), Sumanasekera WK (2003), Taipale M (2012), Donley C (2013), Donley C (2013), Dhamad AE (2016)	13
IKBKG	0	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Zhao T (2007), Zhou AY (2013)	2
CYLD	2	IMPDH2	3	affinity chromatography technology	Elliott PR (2016)	1
IKBKE	2	ROCK2	2	affinity chromatography technology	Ewing RM (2007)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
RNF11	0	TNIP1	1	two hybrid	Colland F (2004)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
ESR1	0	IKBKE	2	affinity chromatography technology	Wang C (2015)	1
HSP90AA1	7	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang K (2006), Taipale M (2012), Liu XY (2010)	3
CYLD	2	ROCK2	2	affinity chromatography technology	Elliott PR (2016)	1
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
TRAF6	0	IKBKE	2	affinity chromatography technology	Fang R (2017)	1
MBP	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Feng M (2012), Feng M (2012)	2
CCT4	2	CCT3	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
CLTC	12	DSTYK	1	affinity chromatography technology	Hein MY (2015)	1
UBC	7	PSMA7	1	affinity chromatography technology	Matsumoto M (2005)	1
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
TANK	1	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method	Bouwmeester T (2004), Rothe M (1996), Rothe M (1996), Nomura F (2000), Nomura F (2000), Pomerantz JL (1999), Behrends C (2010), Li S (2011), Li S (2011), Li C (2002), Shen RR (2012), Shen RR (2012), Wang J (2011), Huttlin EL (2017), Kim CM (2017)	15
BIRC3	1	IKBKE	2	enzymatic study	Zhou AY (2013)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
PPP2R1A	8	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Aranda-Orgilles B (2008), Gano JJ (2010)	2
UBC	7	CALCOCO2	0	pull down, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique	Fenner BJ (2009), Fenner BJ (2009), Rolland T (2014), Tumbarello DA (2015), Xie X (2015), Xie X (2015), Xie X (2015), Xie X (2015), Ordureau A (2015), Minowa-Nozawa A (2017)	10
CYLD	2	SND1	4	affinity chromatography technology	Elliott PR (2016)	1
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
IKBKE	2	RUVBL2	4	affinity chromatography technology	Ewing RM (2007)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
IKBKE	2	HYOU1	2	affinity chromatography technology	Ewing RM (2007)	1
IKBKE	2	LARS	1	affinity chromatography technology	Ewing RM (2007)	1
CHUK	5	CDC37	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen G (2002), Li S (2011), Taipale M (2014), Taipale M (2014), Li J (2013)	5
UBC	7	CCT3	1	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
UBC	7	TNIP1	1	affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down	Wagner S (2008), Wagner S (2008), Fenner BJ (2009), Verhelst K (2012), Zhang X (2017), Kliza K (2017)	6
DDX58	3	IKBKE	2	affinity chromatography technology	Oshiumi H (2013)	1
IKBKE	2	3324	0	affinity chromatography technology	Bouwmeester T (2004)	1
IKBKE	2	NMRAL1	1	affinity chromatography technology	Peng Y (2014)	1
IKBKE	2	RNF11	0	affinity chromatography technology, affinity chromatography technology	Charoenthongtrakul S (2013), Charoenthongtrakul S (2013)	2
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
IKBKE	2	CCT6A	1	affinity chromatography technology	So J (2015)	1
CCT3	1	CCT8	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
YAP1	0	PML	7	affinity chromatography technology, affinity chromatography technology	Lapi E (2008), Lapi E (2008)	2
IKBKE	2	NFKBIA	0	enzymatic study	Zhang W (2010)	1
CCT2	1	CCT4	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
IKBKE	2	PDIA6	1	affinity chromatography technology	Ewing RM (2007)	1
MYD88	1	CYLD	2	affinity chromatography technology	Lee BC (2016)	1
IKBKE	2	MBP	0	enzymatic study	Ikeda F (2007)	1
TRAF3IP2	0	CHUK	5	affinity chromatography technology, biochemical	Leonardi A (2000), Mauro C (2003)	2
IKBKG	0	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Chen G (2002), Taipale M (2014), Taipale M (2014), Liu D (2014), Hein MY (2015), Hein MY (2015), Li J (2013)	8
MAVS	1	BIRC2	1	affinity chromatography technology	Mao AP (2010)	1
CCT5	1	CCT6A	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ESR1	0	CLTC	12	affinity chromatography technology	Tarallo R (2011)	1
TBK1	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Wang L (2012), Liu XY (2011), Liu S (2015), Fang R (2017), Zhang Q (2017)	7
IKBKE	2	CCT3	1	affinity chromatography technology	So J (2015)	1
IKBKG	0	TAX1BP1	3	two hybrid	Wang J (2011)	1
PPP2R1A	8	CDC37	0	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
CHUK	5	ESR1	0	imaging technique	Park KJ (2005)	1
UBC	7	ACLY	3	pull down, affinity chromatography technology	Nathan JA (2013), Bish RA (2007)	2
IKBKE	2	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Saitoh T (2005)	2
DDX3X	52	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology	Gu L (2017), Gu L (2017), Gu L (2017)	3
IKBKE	2	MYD88	1	affinity chromatography technology	Zhou AY (2013)	1
TRAF3	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013)	2
CALCOCO2	0	IKBKG	0	two hybrid	Wang J (2011)	1
CYLD	2	CCT8	0	affinity chromatography technology	Elliott PR (2016)	1
DDX58	3	UBC	7	pull down, pull down	Feng M (2012), Zeng W (2010)	2
TCP1	0	CCT5	1	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
VCP	6	CCT8	0	affinity chromatography technology	Yu CC (2013)	1
YAP1	0	CCT2	1	affinity chromatography technology	Enzo E (2015)	1
BIRC3	1	TANK	1	affinity chromatography technology	Goncharov T (2013)	1
CCT5	1	CCT8	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
VCP	6	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai RM (1998), Dai RM (1998), Gao Y (2000), Hotta K (2013), Yu CC (2013), Li JM (2013), Li JM (2013), Schweitzer K (2016)	8
TAX1BP1	3	TBK1	1	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Goodwin JM (2017)	2
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
CALCOCO2	0	TBKBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Thurston TL (2009), Li S (2011), Huttlin EL (2017)	3
IKBKB	1	RELA	1	enzymatic study, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology	Buss H (2004), Schwabe RF (2005), Dan HC (2008), Chen TC (2014), Busch F (2012)	5
VCP	6	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology	Ohama T (2010), Yakovlev VA (2013)	2
MAFB	1	IKBKE	2	affinity chromatography technology	Kim H (2010)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
IKBKE	2	CCT2	1	affinity chromatography technology	So J (2015)	1
IKBKE	2	TCP1	0	affinity chromatography technology	So J (2015)	1
HSP90AA1	7	TCP1	0	affinity chromatography technology	Falsone SF (2005)	1
YAP1	0	TBK1	1	affinity chromatography technology, affinity chromatography technology	Zhang Q (2017), Zhang Q (2017)	2
CDC37	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
IKBKE	2	PLS3	1	affinity chromatography technology	Ewing RM (2007)	1
SND1	4	PLS3	1	affinity chromatography technology	Boldt K (2016)	1
DDX3X	52	IRF3	4	affinity chromatography technology	Gu L (2017)	1
TMEM173	0	TRAF2	1	affinity chromatography technology	Yao X (2016)	1
CYLD	2	TCP1	0	affinity chromatography technology	Elliott PR (2016)	1
IRF3	4	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Liu S (2015), Liu S (2015), Zhou Z (2014)	6
CLTC	12	CCT3	1	biochemical	Wan C (2015)	1
MAVS	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paz S (2009), Li S (2011), Paz S (2011), Paz S (2011), Fang R (2017)	5
CD209	0	IKBKE	2	affinity chromatography technology	Gringhuis SI (2014)	1
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
RUVBL2	4	3324	0	affinity chromatography technology	Jeronimo C (2007)	1
AZI2	1	TRAF3	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
CCT4	2	CCT5	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CD209	0	CYLD	2	affinity chromatography technology	Gringhuis SI (2014)	1
TCP1	0	CCT6A	1	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
CCT2	1	CCT8	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
TRAF6	0	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
HSP90AA1	7	CHUK	5	affinity chromatography technology, affinity chromatography technology	Qu X (2012), Gano JJ (2010)	2
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
ESR1	0	DDX3X	52	affinity chromatography technology, affinity chromatography technology, pull down	Ambrosino C (2010), Tarallo R (2011), Nalvarte I (2010)	3
TBK1	1	CDC37	0	affinity chromatography technology	Bouwmeester T (2004)	1
TRAF3IP2	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian Y (2002), Qian Y (2004), Boisson B (2013)	3
PML	7	RELA	1	affinity chromatography technology, affinity chromatography technology	Wu WS (2003), Chen Y (2015)	2
VCP	6	CCT3	1	affinity chromatography technology	Yu CC (2013)	1
IKBKE	2	SND1	4	affinity chromatography technology	Ewing RM (2007)	1
IKBKE	2	DSTYK	1	affinity chromatography technology	Ewing RM (2007)	1
TNIP1	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Gao L (2011), Gao L (2011), Rolland T (2014)	3
YAP1	0	HYOU1	2	affinity chromatography technology	Hauri S (2013)	1
CALCOCO2	0	TRAF6	0	two hybrid	Wang J (2011)	1
CYLD	2	3324	0	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	CLTC	12	affinity chromatography technology	Elliott PR (2016)	1
TMEM173	0	MAVS	1	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Chen X (2014)	2
CCT2	1	HSP90AA1	7	affinity chromatography technology	Lin YF (2012)	1
IKBKE	2	CALCOCO2	0	affinity chromatography technology	Thurston TL (2009)	1
TBK1	1	IRF3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Friedman CS (2008), Li S (2011), Li S (2011), Cui J (2012), Piao W (2009), Nakhaei P (2012), Ikeda F (2007), Ikeda F (2007), Ng MH (2011), Wang L (2012), Yang K (2006), Yang K (2006), Liu XY (2010), Liu S (2015), Liu S (2015), Freischmidt A (2015), Zhang Q (2017), Zhang Q (2017)	18
NFKBIA	0	MAVS	1	affinity chromatography technology	Liu S (2015)	1
IKBKE	2	PSMA7	1	affinity chromatography technology	Ewing RM (2007)	1
TNFAIP3	3	CHUK	5	affinity chromatography technology	Zetoune FS (2001)	1
CYLD	2	CDC37	0	affinity chromatography technology	Elliott PR (2016)	1
TRAF3IP2	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Qu F (2012), Qu F (2012), Qu F (2012)	3
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
CHUK	5	NFKBIA	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	DiDonato JA (1997), Cohen L (1998), Woronicz JD (1997), Ninomiya-Tsuji J (1999), Burke JR (2002), Wu ZH (2010), Tong KM (2008), Singhirunnusorn P (2005), Heilker R (1999), Huang TT (2002), Lee FS (1998), Kim KS (2002), Cappello C (2007), Hong S (2007), Morrison BH (2007), Zandi E (1998), Li Q (2006), Manna SK (2010), Li XH (2001), Poyet JL (2001), Zhang W (2010), Bauer JA (2007), Chan H (2005), Munzert G (2002), Stehlik C (2002), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Mitsuhashi S (2008), Hayashi T (2007), Niu J (2013), Dan HC (2008), Criollo A (2010), Kim Y (2002), Huttlin EL (2015), Liu D (2014), Zhang H (2004), Aggarwal S (2006), Ninomiya-Tsuji J (2003), Huttlin EL (2017)	41
TBK1	1	RELA	1	affinity chromatography technology, enzymatic study, enzymatic study	Bouwmeester T (2004), Buss H (2004), Fujita F (2003)	3
UBC	7	TAX1BP1	3	pull down, x-ray crystallography, pull down, pull down	Fenner BJ (2009), Tumbarello DA (2015), Tumbarello DA (2015), Zhang X (2017)	4
CYLD	2	VCP	6	affinity chromatography technology	Elliott PR (2016)	1
TRAF3	1	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
TBKBP1	2	IKBKE	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Ryzhakov G (2007), Ryzhakov G (2007)	3
EPRS	2	TCP1	0	biochemical	Havugimana PC (2012)	1
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
RNF11	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shembade N (2009), Pranski EL (2012), Kelly C (2012), Colland F (2004)	4
IKBKB	1	FKBP5	0	affinity chromatography technology	Li S (2011)	1
DDX3X	52	MAVS	1	pull down, affinity chromatography technology	Gu L (2017), Gu L (2017)	2
TRAF3	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology	Chen X (2014), Yao X (2016)	2
ESR1	0	RUVBL2	4	affinity chromatography technology	Tarallo R (2011)	1
FKBP5	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TANK	1	IRF3	4	affinity chromatography technology	Gatot JS (2007)	1
CYLD	2	RUVBL2	4	affinity chromatography technology	Elliott PR (2016)	1
IKBKG	0	3324	0	affinity chromatography technology	Bouwmeester T (2004)	1
IFIT3	1	PABPC1	5	affinity chromatography technology	Pichlmair A (2011)	1
UBC	7	RUVBL2	4	affinity chromatography technology	Matsumoto M (2005)	1
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
IKBKE	2	IMPDH2	3	affinity chromatography technology	Ewing RM (2007)	1
CCT2	1	CCT5	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
UBC	7	CCT6A	1	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
TBK1	1	3324	0	affinity chromatography technology	Bouwmeester T (2004)	1
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
UBC	7	CCT4	2	affinity chromatography technology	Bish RA (2007)	1
VCP	6	CCT4	2	affinity chromatography technology	Yu CC (2013)	1
TBK1	1	TANK	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Bouwmeester T (2004), Pomerantz JL (1999), Gatot JS (2007), Li S (2011), Li S (2011), Shen RR (2012), Ryzhakov G (2007), Wang J (2011), Seo S (2013), Saul VV (2014), Richter B (2016), Shostak K (2014)	12
IKBKE	2	RELA	1	enzymatic study	Buss H (2004)	1
DDX58	3	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gack MU (2010), Gack MU (2009), Nistal-Villan E (2010), Kawai T (2005), Li S (2011), Li S (2011), Inn KS (2011), Arnaud N (2011), Maharaj NP (2011), Meylan E (2005), Xu LG (2005), Cui J (2010), Wei C (2010), Zhang H (2015), Tan P (2017)	15
TRIM27	2	PML	7	affinity chromatography technology	Cao T (1998)	1
YAP1	0	MYH10	9	affinity chromatography technology	Enzo E (2015)	1
VCP	6	TCP1	0	affinity chromatography technology	Yu CC (2013)	1
PPP2R1A	8	ACLY	3	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
NFKBIA	0	RELA	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Lf (2001), Kiernan R (2003), Kiernan R (2003), Spencer E (1999), Spencer E (1999), Hay DC (2001), Hansen SK (1994), Malek S (1998), Cohen L (1998), Robert I (2009), Sasaki CY (2005), Wu BY (1995), Fagan-Garcia K (2011), Livolsi A (2001), Van Antwerp DJ (1996), Van Antwerp DJ (1996), Krappmann D (1996), Chen Z (1995), Bottero V (2001), Wang H (2010), DiDonato J (1996), Carvalho G (2010), Carvalho G (2010), Suzuki H (1999), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Pringle LM (2011), Pringle LM (2011), Pringle LM (2011), DiDonato J (1996), Ryo A (2003), Ryo A (2003), Inan MS (2000), Burstein E (2005), Chu ZL (1996), Chu ZL (1996), Starokadomskyy P (2013), Wang J (2011), Arenzana-Seisdedos F (1995), Arenzana-Seisdedos F (1997), Wood KM (1998), Cockman ME (2006), Cockman ME (2006), Li JM (2013), Rodriguez MS (1999), Huttlin EL (2015), Hein MY (2015), Taura M (2015), Kim MY (2015), Schweitzer K (2016), Schweitzer K (2016), Hochrainer K (2015), Jiang GM (2017), Huttlin EL (2017), Kumar S (2012), Kumar S (2012)	56
TNFAIP3	3	TNIP1	1	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Heyninck K (1999), Heyninck K (1999), Bohgaki M (2008), Klinkenberg M (2001), Heyninck K (2003), Wang J (2011), Rodriguez MS (2014), Rolland T (2014)	8
TRIM27	2	IKBKB	1	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
IKBKE	2	APPBP2	3	affinity chromatography technology	So J (2015)	1
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
TAX1BP1	3	IKBKE	2	affinity chromatography technology	Gao L (2011)	1
IKBKB	1	NFKBIA	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Mercurio F (1999), Cohen L (1998), Woronicz JD (1997), Burke JR (2002), Tsuchiya Y (2010), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Ducut Sigala JL (2004), Heilker R (1999), Edinger RS (2009), Lee FS (1998), Hai T (2006), Zandi E (1998), Henkler F (2003), Li XH (2001), Byun MS (2006), Mauro C (2003), Zhang W (2010), Munzert G (2002), Shibata Y (2012), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Gao H (2004), Hauenstein AV (2014), Fujita H (2014), Zhang J (2013), Chong RA (2014), Dan HC (2008), Sun L (2004), Criollo A (2010), Liu D (2014), Vincendeau M (2016), Zhang L (2015), Zilberman-Rudenko J (2016), Minassian A (2015), Lindstroem TM (2008), Kim BH (2008), Pandey MK (2008), Joo M (2005), Ninomiya-Tsuji J (2003), Chang YJ (2004), Huang WC (2004), Kim EK (2017), Mei ZZ (2016), Shinohara H (2016), Shkoda A (2012)	48
TOPORS	6	PML	7	imaging technique	Renner F (2010)	1
UBC	7	PPP2R1A	8	affinity chromatography technology	Matsumoto M (2005)	1
CYLD	2	HSP90AA1	7	affinity chromatography technology	Elliott PR (2016)	1
IKBKE	2	KTN1	1	affinity chromatography technology	Bouwmeester T (2004)	1
LARS	1	PPP2R1A	8	genetic interference	Horlbeck MA (2018)	1
IKBKE	2	MYH10	9	affinity chromatography technology	Ewing RM (2007)	1
IKBKE	2	YAP1	0	affinity chromatography technology	Zhang Q (2017)	1
CYLD	2	PABPC1	5	affinity chromatography technology	Elliott PR (2016)	1
YAP1	0	CCT5	1	affinity chromatography technology	Enzo E (2015)	1
TNIP1	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Gao L (2011), Gao L (2011)	2
DDX3X	52	SND1	4	biochemical	Kristensen AR (2012)	1
TBK1	1	TBKBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Li S (2011), Li S (2011), Ryzhakov G (2007), Ryzhakov G (2007), Ryzhakov G (2007), Seo S (2013), Richter B (2016)	8
TRAF3	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kayagaki N (2007), Mankouri J (2010), Mankouri J (2010), Tzieply N (2012), Wang Y (2012), Ng MH (2011), Charoenthongtrakul S (2013), van Zuylen WJ (2012), van Zuylen WJ (2012), Karim R (2013), Chen X (2014), Peng Y (2014), Wang S (2013), Zhou Y (2016), Cai B (2017), Fang R (2017), Fang R (2017)	17
TMEM173	0	IRF3	4	affinity chromatography technology, affinity chromatography technology	Chen X (2014), Liu S (2015)	2
IKBKE	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Zhou AY (2013)	2
TRAF6	0	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
TRAF3IP2	0	IKBKB	1	affinity chromatography technology, biochemical, affinity chromatography technology	Leonardi A (2000), Mauro C (2003), Valente AJ (2014)	3
IKBKG	0	RELA	1	enzymatic study	Dan HC (2008)	1
IKBKG	0	TANK	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Chariot A (2002), Chariot A (2002), Chariot A (2002), Zhang W (2010), Zhang W (2010), Zhao T (2007), Wang J (2011), Wang W (2015), Huttlin EL (2017)	9
XIAP	0	IRF3	4	affinity chromatography technology	Nakhaei P (2012)	1
MAFB	1	IRF3	4	affinity chromatography technology, affinity chromatography technology	Kim H (2010), Kim H (2010)	2
CYLD	2	PDIA6	1	affinity chromatography technology	Elliott PR (2016)	1
IKBKB	1	HSP90AA1	7	affinity chromatography technology	Xue J (2010)	1
IKBKE	2	PPP2R1A	8	affinity chromatography technology	Ewing RM (2007)	1
IKBKB	1	CDC37	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen G (2002), Chen G (2002), Li S (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015)	6
CCT3	1	CCT6A	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
CCT5	1	CCT3	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
MYD88	1	TRAF3	1	affinity chromatography technology	Zhou J (2011)	1
CCT2	1	XIAP	0	pull down, affinity chromatography technology	Lin YF (2012), Lin YF (2012)	2
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
ESR1	0	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Olivier S (2006), Nettles KW (2008), Nettles KW (2008), Rubio MF (2006), Rubio MF (2006)	5
CYLD	2	CCT5	1	affinity chromatography technology	Elliott PR (2016)	1
DDX58	3	TBK1	1	affinity chromatography technology	Oshiumi H (2013)	1
TRAF3	1	BIRC3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mao AP (2010), de Jong SJ (2013), Goncharov T (2013)	3
CHUK	5	RELA	1	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Hoberg JE (2006), Buss H (2004), Li S (2011), Dan HC (2008), Huang WC (2007), Busch F (2012)	6
ESR1	0	TBK1	1	affinity chromatography technology	Wang C (2015)	1
NMRAL1	1	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Peng Y (2014), Peng Y (2014)	2
TBK1	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsuchida T (2010), Li S (2011), Zhang J (2012), Zhang J (2012), Chen X (2014), Ni G (2017), Zhang Q (2017)	7
EPRS	2	HSP90AA1	7	two hybrid, affinity chromatography technology, pull down, biochemical	Kang J (2000), Kang J (2000), Kang J (2000), Kang J (2000)	4
CALCOCO2	0	AZI2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Huttlin EL (2017)	3
IRF3	4	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Ng MH (2011), Gu L (2017)	2
YAP1	0	VCP	6	affinity chromatography technology	Enzo E (2015)	1
CYLD	2	CCT6A	1	affinity chromatography technology	Elliott PR (2016)	1
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
IKBKG	0	MYD88	1	pull down	Emmerich CH (2013)	1
CALCOCO2	0	MAVS	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IKBKE	2	ACLY	3	affinity chromatography technology	Ewing RM (2007)	1
TANK	1	TRAF3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology	Bouwmeester T (2004), Rothe M (1996), Gatot JS (2007), Li S (2011), Li C (2003), Li C (2002), Li C (2002), Ng MH (2011)	8
IKBKB	1	IKBKE	2	enzymatic study, affinity chromatography technology	Heilker R (1999), Zhou AY (2013)	2
AZI2	1	TBKBP1	2	affinity chromatography technology, affinity chromatography technology	Ryzhakov G (2007), Ryzhakov G (2007)	2
VCP	6	CDC37	0	affinity chromatography technology	Yu CC (2013)	1
ESR1	0	CCT2	1	pull down, affinity chromatography technology	Nalvarte I (2010), Han SJ (2016)	2
TBK1	1	MBP	0	enzymatic study	Ikeda F (2007)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
PSMA7	1	VCP	6	two hybrid	Wang J (2011)	1
IMPDH2	3	DDX3X	52	biochemical	Wan C (2015)	1
TRAF3	1	TAX1BP1	3	affinity chromatography technology	Gao L (2011)	1
CDC37	0	IFIT3	1	two hybrid, pull down, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
IKBKE	2	ATIC	6	affinity chromatography technology	Ewing RM (2007)	1
UBC	7	APPBP2	3	affinity chromatography technology	Matsumoto M (2005)	1
MAVS	1	TAX1BP1	3	affinity chromatography technology	Choi YB (2017)	1
TRAF3IP2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Wu L (2014), Boisson B (2013)	2
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
CCT2	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology	Lin YF (2012), Lin YF (2012), Yu CC (2013)	3
VCP	6	CCT6A	1	affinity chromatography technology	Yu CC (2013)	1
ESR1	0	FKBP5	0	pull down, affinity chromatography technology	Nair SC (1996), Dhamad AE (2016)	2
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
TOPORS	6	IKBKE	2	imaging technique, affinity chromatography technology	Renner F (2010), Renner F (2010)	2
ESR1	0	PABPC1	5	affinity chromatography technology	Tarallo R (2011)	1
TRIM27	2	CHUK	5	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
ESR1	0	PPP2R1A	8	pull down, affinity chromatography technology	Nalvarte I (2010), Okada M (2015)	2
AZI2	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Li S (2011), Ryzhakov G (2007)	2
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
IRF3	4	TRAF6	0	affinity chromatography technology	Liu S (2015)	1
DDX58	3	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
TBK1	1	CALCOCO2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Thurston TL (2009), Li S (2011), Li S (2011), Li S (2011), Li S (2011), Huttlin EL (2017)	6
FKBP5	0	HSP90AA1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1997), Nair SC (1997), Li J (2011), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Ni L (2010), Luo K (2017)	13
YAP1	0	PPP2R1A	8	affinity chromatography technology	Enzo E (2015)	1
IKBKE	2	CLTC	12	affinity chromatography technology	Ewing RM (2007)	1
IKBKG	0	TNIP1	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Ashida H (2010), Wagner S (2008), Wang J (2011)	3
IKBKG	0	NMRAL1	1	affinity chromatography technology	Li T (2014)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
CYLD	2	CCT4	2	affinity chromatography technology	Elliott PR (2016)	1
RNF11	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Shembade N (2009), Colland F (2004)	2
CYLD	2	PSMA7	1	affinity chromatography technology	Elliott PR (2016)	1
CCT5	1	VCP	6	biochemical, affinity chromatography technology	Havugimana PC (2012), Yu CC (2013)	2
YAP1	0	EPRS	2	affinity chromatography technology	Enzo E (2015)	1
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
CALCOCO2	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Morriswood B (2007), Morriswood B (2007)	2
UBC	7	CCT2	1	affinity chromatography technology	Bish RA (2007)	1
EPRS	2	LARS	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
CHUK	5	IKBKE	2	enzymatic study	Heilker R (1999)	1
YAP1	0	SND1	4	affinity chromatography technology	Enzo E (2015)	1
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
ESR1	0	LARS	1	pull down	Nalvarte I (2010)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
TNFAIP3	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gao L (2011), Saitoh T (2005)	3
IKBKE	2	CCT4	2	affinity chromatography technology	So J (2015)	1
IKBKE	2	PABPC1	5	affinity chromatography technology	Ewing RM (2007)	1
IKBKE	2	DDX3X	52	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Schroeder M (2008), Schroeder M (2008), Gu L (2017), Gu L (2017)	4
CCT4	2	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
CCT2	1	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
TCP1	0	CCT8	0	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
TBK1	1	RNF11	0	affinity chromatography technology, affinity chromatography technology	Charoenthongtrakul S (2013), Charoenthongtrakul S (2013)	2
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
PML	7	IKBKE	2	imaging technique	Renner F (2010)	1
TCP1	0	CCT3	1	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
IKBKE	2	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
IKBKE	2	XIAP	0	enzymatic study	Nakhaei P (2012)	1
IKBKE	2	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
CYLD	2	EPRS	2	affinity chromatography technology	Elliott PR (2016)	1
CCT4	2	CCT8	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TNFAIP3	3	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	De Valck D (1999), De Valck D (1999), Klinkenberg M (2001), Kelly C (2012), Huttlin EL (2017)	5