PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RRAS2	0	AFDN	10	two hybrid	Murphy GA (2002)	1
RIN1	1	ANKS1A	3	affinity chromatography technology	Huttlin EL (2017)	1
YWHAE	0	AFDN	10	affinity chromatography technology	Gloeckner CJ (2007)	1
HRAS	2	RALGDS	4	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, imaging technique	Mitin NY (2004), Li W (2000), Boettner B (2000), Hofer F (1994), Hofer F (1994), Miller MJ (1997), Spaargaren M (1994), Spaargaren M (1994), Rodriguez-Viciana P (1997), Stang S (1997), Bandyopadhyay S (2010), Nancy V (2002), Chen TC (2014)	13
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
YWHAG	5	AFDN	10	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
TES	1	RIN1	1	affinity chromatography technology	Sala S (2017)	1
YWHAZ	1	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), Yoshida K (2005), So J (2015)	5
RIN1	1	LZTS2	4	two hybrid	Rolland T (2014)	1
COMT	2	RIN1	1	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2009), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
ERBB2	6	ANKS1B	2	unspecified method	Jones RB (2006)	1
YWHAG	5	ANKS1A	3	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
ZWINT	1	RIN1	1	affinity chromatography technology	Hein MY (2015)	1
RIN1	1	KRAS	1	affinity chromatography technology	Huttlin EL (2017)	1
RIN1	1	RRAS	2	affinity chromatography technology	Huttlin EL (2017)	1
ABL2	4	RIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu H (2005), Hu H (2005), Huttlin EL (2017)	3
ERBB3	3	RIN1	1	unspecified method	Jones RB (2006)	1
ABL1	9	ABL2	4	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Cao C (2003), Cao C (2003), Cao C (2003), Cao C (2005)	4
EGFR	5	ANKS1A	3	unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
RAB5A	0	RIN1	1	two hybrid, affinity chromatography technology	Tall GG (2001), Kong C (2007)	2
RRAS	2	RALGDS	4	two hybrid, pull down	Spaargaren M (1994), Spaargaren M (1994)	2
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
EGFR	5	STAM2	0	affinity chromatography technology, pull down	Kong C (2007), Morino C (2004)	2
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
ABL1	9	EGFR	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
RRAS2	0	RIN1	1	two hybrid, two hybrid, affinity chromatography technology	Murphy GA (2002), Venkatesan K (2009), Huttlin EL (2017)	3
HRAS	2	AFDN	10	two hybrid, pull down, affinity chromatography technology	Boettner B (2000), Yamamoto T (1999), Yamamoto T (1999)	3
RAP2B	0	RIN1	1	affinity chromatography technology	Boldt K (2016)	1
EGFR	5	ABL2	4	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
RIN1	1	YWHAZ	1	affinity chromatography technology	Huttlin EL (2017)	1
RIN1	1	STAM2	0	affinity chromatography technology, affinity chromatography technology	Kong C (2007), Balaji K (2012)	2
RIN1	1	ANKS1B	2	two hybrid	Grossmann A (2015)	1
LZTS2	4	ISCA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
RAB5B	1	RIN1	1	two hybrid	Tall GG (2001)	1
RIN1	1	ABL1	9	affinity chromatography technology	Huttlin EL (2017)	1
RIN1	1	AFDN	10	two hybrid	Shao H (1999)	1
ABL1	9	ERBB2	6	unspecified method	Jones RB (2006)	1
YWHAH	0	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
RIN1	1	ISCA1	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	RIN1	1	affinity chromatography technology	Kong C (2007)	1
RIN1	1	YWHAH	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	ANKS1B	2	unspecified method	Jones RB (2006)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
RIN1	1	NRAS	1	affinity chromatography technology	Huttlin EL (2017)	1
KRAS	1	EGFR	5	genetic interference	Hart T (2015)	1
RIN1	1	YWHAE	0	affinity chromatography technology	Huttlin EL (2017)	1
YWHAG	5	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
RRAS2	0	RALGDS	4	two hybrid, two hybrid	Murphy GA (2002), Wang J (2011)	2
DPP8	2	RIN1	1	affinity chromatography technology	Boldt K (2016)	1
YWHAE	0	ABL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raina D (2006), Yoshida K (2005), Yoshida K (2005), So J (2015)	4
RALGDS	4	RAP2B	0	pull down, two hybrid	Nancy V (1999), Nancy V (2002)	2
HRAS	2	ABL2	4	affinity chromatography technology, affinity chromatography technology	Hu H (2005), Hu H (2005)	2
RIN1	1	YWHAG	5	affinity chromatography technology	Huttlin EL (2017)	1
KRAS	1	RALGDS	4	two hybrid, two hybrid, pull down, two hybrid	Li W (2000), Spaargaren M (1994), Spaargaren M (1994), Wang J (2011)	4
RIN1	1	RALGDS	4	two hybrid	Shao H (1999)	1
ERBB3	3	ABL2	4	unspecified method	Jones RB (2006)	1
ERBB2	6	ABL2	4	unspecified method	Jones RB (2006)	1
SMAD2	5	RIN1	1	affinity chromatography technology	Brown KA (2008)	1
ERBB2	6	RIN1	1	unspecified method	Jones RB (2006)	1
ERBB2	6	ANKS1A	3	unspecified method	Jones RB (2006)	1
SMAD2	5	AFDN	10	two hybrid	Colland F (2004)	1
RIN1	1	CALCOCO2	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
AFDN	10	NRAS	1	affinity chromatography technology	Radziwill G (2003)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
ABL1	9	ERBB3	3	unspecified method	Jones RB (2006)	1
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3
HRAS	2	RIN1	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Mitin NY (2004), Han L (1995), Han L (1995), Hu H (2005), Huttlin EL (2017)	5