PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PYM1	3	MAD2L1	0	affinity chromatography technology	Huttlin EL (2017)	1
BUB1B	0	TRIP13	0	affinity chromatography technology, pull down	Wang K (2014), Miniowitz-Shemtov S (2015)	2
DHX40	3	MAD2L1BP	0	biochemical	Havugimana PC (2012)	1
MAD2L1	0	TRIP13	0	affinity chromatography technology, pull down, affinity chromatography technology	Wang K (2014), Miniowitz-Shemtov S (2015), Sedgwick GG (2016)	3
CDC20	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kramer ER (1998), Kallio M (1998), Kallio M (1998), Nilsson J (2008), Jeganathan KB (2006), Nath S (2011), Lee YJ (2008), Lara-Gonzalez P (2011), Mansfeld J (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Lee YJ (2008), DAngiolella V (2003), Lee SJ (2012), Fang G (1998), Fang G (1998), Wolthuis R (2008), Ban KH (2007), Ge S (2009), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Kwan PS (2013), Sedgwick GG (2012), Eytan E (2013), Hyun SY (2013), Lim HJ (2013), Choi BH (2014), Fogeron ML (2013), Sackton KL (2014), Shoji S (2014), Han JS (2014), Lara-Gonzalez P (2011), Hein JB (2014), Vodermaier HC (2003), Yen AH (2010), Voets E (2015), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Craney A (2016), Listovsky T (2013), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	54
TRIP13	0	CDC20	1	pull down, pull down	Miniowitz-Shemtov S (2015), Miniowitz-Shemtov S (2015)	2
MAD2L1	0	TSC22D4	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
BUB1B	0	MAD2L1BP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miniowitz-Shemtov S (2012), Westhorpe FG (2011), Westhorpe FG (2011)	3
KRT15	2	MAD2L1BP	0	two hybrid	Rual JF (2005)	1
CDC20	1	BUB1B	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Fang G (2002), Fang G (2002), Wu H (2000), Wu H (2000), Wu H (2000), Kallio MJ (2002), Sudakin V (2001), Sudakin V (2001), Skoufias DA (2001), Nilsson J (2008), Ho CY (2010), Ho CY (2010), Garnett MJ (2009), Hutchins JR (2010), Di Fiore B (2010), Di Fiore B (2010), Mansfeld J (2011), Jia L (2011), Braunstein I (2007), Eytan E (2008), Eytan E (2008), Ma HT (2011), Miniowitz-Shemtov S (2012), Tang Z (2001), Tang Z (2001), Tang Z (2001), Tang Z (2001), Bolanos-Garcia VM (2011), Ge S (2009), Liu L (2007), Westhorpe FG (2011), Westhorpe FG (2011), Kwan PS (2013), Tian W (2012), Tian W (2012), Tian W (2012), Santaguida S (2011), Hyun SY (2013), Han JS (2013), Rodriguez-Bravo V (2014), Fogeron ML (2013), Wang K (2014), Han JS (2014), Izawa D (2014), Hein JB (2014), So J (2015), Scialpi F (2015), Scialpi F (2015), Diaz-Martinez LA (2015), Diaz-Martinez LA (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Voets E (2015), Chen TC (2014), Lischetti T (2014), Lischetti T (2014), Lischetti T (2014), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Sedgwick GG (2016), Qiao R (2016), Huttlin EL (2017), Izawa D (2012), Jia L (2016), Jia L (2016), Hein JB (2016), Kaisari S (2017)	73
MAD2L1BP	0	SEPT11	2	biochemical	Havugimana PC (2012)	1
CDC27	2	MAD1L1	2	affinity chromatography technology	Westhorpe FG (2011)	1
RIT1	1	MAD2L1BP	0	affinity chromatography technology	Huttlin EL (2017)	1
PTPN22	3	MAD2L1BP	0	affinity chromatography technology	Li X (2016)	1
BUB1B	0	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chan GK (1999), Hutchins JR (2010), Lara-Gonzalez P (2011), Mansfeld J (2011), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Eytan E (2013), Wang K (2014), Han JS (2014), Han JS (2014), Lara-Gonzalez P (2011), So J (2015), Boekhout M (2015), Kelly A (2014), Craney A (2016), Qiao R (2016)	17
MAD2L1BP	0	HOMEZ	2	two hybrid	Rolland T (2014)	1
TOR1AIP1	2	MAD2L1BP	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC27	2	MAD2L1BP	0	affinity chromatography technology	Westhorpe FG (2011)	1
BUB1B	0	MAD2L1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sudakin V (2001), Sudakin V (2001), Ho CY (2010), Bolanos-Garcia VM (2011), Tipton AR (2011), Tipton AR (2011), Tipton AR (2011), Westhorpe FG (2011), Eytan E (2013), Han JS (2013), Wang K (2014), Wang K (2014), So J (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Lischetti T (2014), Tipton AR (2013), Tipton AR (2013), Boekhout M (2015), Sedgwick GG (2016), Sedgwick GG (2016), Sedgwick GG (2016)	23
MAD1L1	2	TRIP13	0	affinity chromatography technology	Wang K (2014)	1
ZBTB14	2	KAT5	1	two hybrid	Rolland T (2014)	1
MAD1L1	2	CDC20	1	affinity chromatography technology, affinity chromatography technology	Rodriguez-Bravo V (2014), Kelly A (2014)	2
MAD2L1	0	MAD1L1	2	two hybrid, pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Sironi L (2001), Murakumo Y (2000), Chen J (2001), Sironi L (2001), Sironi L (2001), Tipton AR (2011), De Antoni A (2005), De Antoni A (2005), Fava LL (2011), Fava LL (2011), Wang J (2011), Rodriguez-Bravo V (2014), Wang K (2014), Hein MY (2015), Sedgwick GG (2016), Sedgwick GG (2016), Yang M (2008), Kim S (2010), Kim S (2010), Theng SS (2014)	21
TP53	0	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2004), Tyteca S (2006), Tyteca S (2006), Kurash JK (2008), Cheng Z (2008), Cheng Z (2008), Cheng Z (2008), Tang Y (2006), Tang Y (2006), Tang Y (2006), Dai C (2013)	11
TP53	0	EEF1A1	0	affinity chromatography technology	Fogeron ML (2013)	1
KAT5	1	NMI	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhang K (2007), Zhang K (2007), Zhang K (2007)	3
MAD2L1BP	0	PTN	0	two hybrid	Stelzl U (2005)	1
MAD2L1BP	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
PYM1	3	MAD2L1BP	0	affinity chromatography technology	Huttlin EL (2017)	1
MAD2L1BP	0	CDC20	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miniowitz-Shemtov S (2012), Westhorpe FG (2011), Westhorpe FG (2011), Lischetti T (2014), Kelly A (2014), Huttlin EL (2017), Izawa D (2012), Jia L (2016)	8
MAD2L1BP	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
NMI	3	MAD2L1BP	0	two hybrid	Rolland T (2014)	1
MAD2L1	0	MAD2L1BP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Habu T (2002), Westhorpe FG (2011), Fava LL (2011), Mapelli M (2006), Rolland T (2014), Hein MY (2015)	6
PTPRO	3	MAD2L1BP	0	affinity chromatography technology	Li X (2016)	1
PTPRR	3	MAD2L1BP	0	affinity chromatography technology	Li X (2016)	1
LBR	1	MAD2L1BP	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC20	1	MAD2L1	0	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, unspecified method, pull down, affinity chromatography technology	Zhang Y (2001), Sihn CR (2003), Luo X (2000), Sironi L (2001), DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kallio M (1998), Fang G (1998), Fang G (1998), Skoufias DA (2001), Nilsson J (2008), Privette LM (2008), Stegmeier F (2007), Ho CY (2010), Ho CY (2010), Mansfeld J (2011), Gao YF (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Townsend K (2009), Lee YJ (2008), DAngiolella V (2003), Tang Z (2001), Tang Z (2001), Sironi L (2001), Sironi L (2001), Ge S (2009), Mapelli M (2007), Tipton AR (2011), Mondal G (2006), Mondal G (2006), Westhorpe FG (2011), De Antoni A (2005), De Antoni A (2005), Kwan PS (2013), Katayama H (2012), Fava LL (2011), Santaguida S (2011), Mapelli M (2006), Eytan E (2013), Eytan E (2013), Hyun SY (2013), Han JS (2013), Rodriguez-Bravo V (2014), Fogeron ML (2013), Wang K (2014), Eytan E (2014), Hein JB (2014), Yen AH (2010), Yen AH (2010), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Lischetti T (2014), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Sedgwick GG (2016), Sedgwick GG (2016), Izawa D (2012), Izawa D (2012), Jia L (2016), Jia L (2016), Kaisari S (2017), Yang M (2008), Kim S (2010), Kim S (2010)	70
MAD2L1BP	0	MAD1L1	2	affinity chromatography technology	Westhorpe FG (2011)	1
ZSCAN29	2	MAD2L1BP	0	affinity chromatography technology	Huttlin EL (2017)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
MAD2L1BP	0	INPP5K	6	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
MAD2L1BP	0	EEF1A1	0	two hybrid	Stelzl U (2005)	1
RIT1	1	PTN	0	two hybrid	Stelzl U (2005)	1
MAD2L1	0	TOR1AIP1	2	affinity chromatography technology	Hein MY (2015)	1
TSC22D4	1	MAD2L1BP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAD2L1BP	0	CEP126	0	two hybrid	Stelzl U (2005)	1
MAD2L1BP	0	TP53	0	two hybrid	Stelzl U (2005)	1
RIT1	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
TRIP13	0	MAD2L1BP	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid, pull down	Rual JF (2005), Rual JF (2005), Stelzl U (2005), Venkatesan K (2009), Miniowitz-Shemtov S (2015)	5
NTF3	2	MAD2L1BP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZBTB14	2	MAD2L1BP	0	two hybrid	Rolland T (2014)	1
MAD2L1BP	0	MAD2L1BP	0	affinity chromatography technology	Westhorpe FG (2011)	1
MAD2L1BP	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
KAT5	1	LRIF1	3	two hybrid	Goehler H (2004)	1
CDC27	2	MAD2L1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wassmann K (1998), Kallio M (1998), Li Y (1997), Li Y (1997), Lara-Gonzalez P (2011), Mansfeld J (2011), Visconti R (2010), Ma HT (2011), Sironi L (2001), Tipton AR (2011), Tipton AR (2011), Westhorpe FG (2011), Eytan E (2013), Lara-Gonzalez P (2011), Yen AH (2010), Hein MY (2015), Craney A (2016), Sedgwick GG (2016)	18
MAD2L1BP	0	KAT5	1	two hybrid	Stelzl U (2005)	1