PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF6	0	DDX3X	52	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Yu J (2016)	2
NCOA6	6	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Ko L (2000), Ko L (2003)	2
CD40	3	CD40	3	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
PIK3R1	6	PIK3CA	8	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Woscholski R (1994), Chamberlain MD (2004), Ren SY (2005), Kamal M (2010), Sun M (2010), Hein MY (2015), Fang D (2001), Xiong Y (2009), Ivanov AA (2017)	9
TRAF2	1	TRAF3IP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Qian Y (2004), Sun D (2011)	3
SGK1	4	HSPA4	3	affinity chromatography technology	Belova L (2006)	1
TRAF6	0	HSPA4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Chen H (2006), Pridgeon JW (2004), Chen H (2006)	3
CD40	3	FAF1	1	affinity chromatography technology, pull down, two hybrid	Elmetwali T (2014), Elmetwali T (2014), Elmetwali T (2014)	3
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
TRAF3IP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Liu C (2009), Kanamori M (2002), Kanamori M (2002), Kanamori M (2002), Qian Y (2007), Qu F (2012), Wu NL (2014), Wu NL (2014), Rolland T (2014), Garg AV (2013), Sun D (2011), Yu H (2011)	12
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
CD40	3	RNF31	3	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
TANK	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Goncharov T (2013)	2
CD40	3	SLC30A7	0	affinity chromatography technology	Ewing RM (2007)	1
CBL	7	HSPA4	3	affinity chromatography technology	Valiya Veettil M (2011)	1
CD40	3	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
CD40	3	SLC39A7	0	affinity chromatography technology	Ewing RM (2007)	1
RIPK2	0	TRAF5	1	affinity chromatography technology	McCarthy JV (1998)	1
CD40	3	RFC5	2	affinity chromatography technology	Ewing RM (2007)	1
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
CD40	3	TRAF5	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Ishida TK (1996), Werneburg BG (2001), Peters AL (2010), Mizushima S (1998), Basaki Y (2002), He B (2010), Hostager BS (2010), Hostager BS (2010)	9
CD40	3	SGK1	4	affinity chromatography technology	Ewing RM (2007)	1
TANK	1	CD40	3	affinity chromatography technology	Qiao G (2007)	1
TRAF1	0	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Greenfeld H (2015), Huttlin EL (2017)	3
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
TANK	1	CHUK	5	affinity chromatography technology	Chariot A (2002)	1
CD40	3	POLR2H	0	affinity chromatography technology	Ewing RM (2007)	1
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
TRAF2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Li S (2011), Huttlin EL (2017)	3
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
TRAF5	1	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology	Sun D (2011), Sun D (2011)	2
CD40	3	CALR	1	affinity chromatography technology	Ewing RM (2007)	1
TRAF1	0	HTRA2	1	affinity chromatography technology	Greenfeld H (2015)	1
CD40	3	XRCC6	3	pull down	Morio T (1999)	1
NCOA6	6	XRCC6	3	affinity chromatography technology, affinity chromatography technology, pull down	Ko L (2000), Ko L (2003), Ko L (2003)	3
TANK	1	TRAF2	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method	Bouwmeester T (2004), Rothe M (1996), Rothe M (1996), Nomura F (2000), Nomura F (2000), Pomerantz JL (1999), Behrends C (2010), Li S (2011), Li S (2011), Li C (2002), Shen RR (2012), Shen RR (2012), Wang J (2011), Huttlin EL (2017), Kim CM (2017)	15
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
BIRC2	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
CD40	3	ERP44	1	affinity chromatography technology	Ewing RM (2007)	1
FAF1	1	IKBKB	1	affinity chromatography technology, pull down, pull down	Park MY (2007), Park MY (2007), Park MY (2007)	3
TRAF3	1	RIPK2	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Cai X (2013), Cai X (2013), Cai X (2013), Cai X (2013)	4
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
CD40	3	TXN	1	affinity chromatography technology	Ewing RM (2007)	1
PIK3CA	8	SGK1	4	pull down	Park J (1999)	1
TRAF6	0	TDP2	2	affinity chromatography technology	Pype S (2000)	1
TRAF3IP2	0	CHUK	5	affinity chromatography technology, biochemical	Leonardi A (2000), Mauro C (2003)	2
CD40LG	0	CD40	3	affinity chromatography technology	Salzmann S (2013)	1
CD40	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Ha YJ (2011), Ha YJ (2011)	2
DDX3X	52	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology	Gu L (2017), Gu L (2017), Gu L (2017)	3
TRAF3	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013)	2
CD40	3	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Hostager BS (2010), Hostager BS (2010)	3
CD40	3	DIABLO	2	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
CD40	3	HTRA2	1	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
TMEM173	0	TRAF2	1	affinity chromatography technology	Yao X (2016)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
CBL	7	TRAF4	1	two hybrid	Woodsmith J (2012)	1
BAG3	4	HSPA4	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2003), Doong H (2003), Gentilella A (2011), Gamerdinger M (2009), Gamerdinger M (2009), Ammirante M (2010), Chen Y (2013), Chen Y (2013)	8
TRAF1	0	TANK	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Rothe M (1996), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017), Kim CM (2017), Kim CM (2017)	6
CD40	3	CBL	7	affinity chromatography technology	Deregibus MC (2003)	1
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TRAF3IP2	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian Y (2002), Qian Y (2004), Boisson B (2013)	3
FAF1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Lee JJ (2012), Kim HJ (2005), Kim HJ (2005), Lee JJ (2013), Lee JJ (2013), Kristensen AR (2012)	6
CBL	7	TRAF2	1	affinity chromatography technology	Xu L (2017)	1
MAP3K8	2	TRAF6	0	affinity chromatography technology	Chan H (2005)	1
NCOA6	6	CD40	3	pull down	Lee SK (2000)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
XRCC5	5	CBL	7	affinity chromatography technology	Hein MY (2015)	1
RIPK2	0	RNF31	3	affinity chromatography technology	Damgaard RB (2012)	1
MAP3K8	2	CHUK	5	enzymatic study, affinity chromatography technology	Lin X (1999), Lin X (1999)	2
CD40	3	MS4A1	1	affinity chromatography technology	Leveille C (1999)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
TRAF3IP2	0	HSPA4	3	affinity chromatography technology	Boisson B (2013)	1
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
TRAF1	0	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
TRAF3	1	TDP2	2	affinity chromatography technology	Pype S (2000)	1
CD40	3	UGGT1	6	affinity chromatography technology	Ewing RM (2007)	1
TRAF5	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Li S (2011), He L (2004), Chen TC (2014)	3
HTRA2	1	DIABLO	2	far western blotting, affinity chromatography technology	Hegde R (2002), Hegde R (2002)	2
CD40	3	TRAF3	1	pull down, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Hu HM (1994), Hu HM (1994), Hu HM (1994), Ni CZ (2000), Roy N (1997), Qiao G (2007), Mosialos G (1995), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Li C (2003), Boucher LM (1997), Graham JP (2009), Sato T (1995), Sato T (1995), Sato T (1995), Deregibus MC (2003), Hostager BS (1999), Basaki Y (2002), Cheng G (1995), Miliara S (2013), Elmetwali T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	27
TRAF2	1	TRAF4	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Zhang X (2013), Zhang X (2013), Zhang X (2013), Ren HY (2015)	4
TRAF3	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology	Chen X (2014), Yao X (2016)	2
CD40	3	CHUK	5	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
BIRC2	1	HTRA2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Hegde R (2003), Verhagen AM (2002), Suzuki Y (2001), Huttlin EL (2017)	5
USP15	4	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2013), Zhang L (2013)	2
MAP3K8	2	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Eliopoulos AG (2002), Chan H (2005)	2
TRAF5	1	TDP2	2	affinity chromatography technology	Pype S (2000)	1
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
TRAF4	1	RIPK2	0	affinity chromatography technology	Marinis JM (2011)	1
TRAF6	0	TRAF5	1	two hybrid, two hybrid, two hybrid, pull down	Woodsmith J (2012), Rolland T (2014), Yu H (2011), Middleton AJ (2017)	4
CD40LG	0	TRAF1	0	affinity chromatography technology	Salzmann S (2013)	1
TRAF6	0	TRAF4	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Takeshita F (2005), Takeshita F (2005), Chen TC (2014)	3
PIK3CA	8	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sattler M (1997), Sattler M (1997), Chernock RD (2001), Chernock RD (2001), Brehme M (2009)	5
CD40	3	RIPK2	0	affinity chromatography technology	McCarthy JV (1998)	1
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
CD40	3	USP15	4	affinity chromatography technology	Ewing RM (2007)	1
CHUK	5	RIPK2	0	enzymatic study	Marinis JM (2012)	1
TRAF1	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Wicovsky A (2009), Henkler F (2003)	2
CD40	3	HSPA4	3	pull down, affinity chromatography technology	Becker T (2002), Becker T (2002)	2
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
TRAF3IP2	0	IKBKB	1	affinity chromatography technology, biochemical, affinity chromatography technology	Leonardi A (2000), Mauro C (2003), Valente AJ (2014)	3
TRAF2	1	HTRA2	1	affinity chromatography technology	Behrends C (2010)	1
CD40	3	MAP3K8	2	affinity chromatography technology	Chan H (2005)	1
CD40	3	TRAF4	1	affinity chromatography technology	Werneburg BG (2001)	1
CD40	3	XRCC5	5	pull down	Morio T (1999)	1
CD40	3	TRAF6	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tsukamoto N (1999), Roy N (1997), Davies CC (2005), Pullen SS (1998), Peters AL (2010), Ye H (2002), Deregibus MC (2003), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Hostager BS (2010), Hostager BS (2010), Verstak B (2014)	14
CD40	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Werneburg BG (2001), Peters AL (2010), Hostager BS (2010), Hostager BS (2010)	4
CD40	3	RNF219	1	affinity chromatography technology	Ewing RM (2007)	1
BAG3	4	CD40	3	affinity chromatography technology	Chen Y (2013)	1
CD40	3	FBL	1	affinity chromatography technology	Ewing RM (2007)	1
IL4R	1	CD40	3	affinity chromatography technology	Doucet C (2002)	1
CD40	3	PIK3CA	8	affinity chromatography technology	Deregibus MC (2003)	1
TANK	1	TRAF3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology	Bouwmeester T (2004), Rothe M (1996), Gatot JS (2007), Li S (2011), Li C (2003), Li C (2002), Li C (2002), Ng MH (2011)	8
CD40	3	TDP2	2	two hybrid, affinity chromatography technology	Pype S (2000), Pype S (2000)	2
BIRC2	1	DIABLO	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hegde R (2003), Verhagen AM (2000), Samuel T (2006), Samuel T (2006), Yang QH (2004), Hu S (2003), Hu S (2003), Csomos RA (2009), Burke SP (2010), Kulathila R (2009), Kulathila R (2009), Arnt CR (2002), Budhidarmo R (2014), Lee S (2014), Wo L (2016), Huttlin EL (2017)	16
CHUK	5	TRAF4	1	enzymatic study	Marinis JM (2012)	1
CD40LG	0	BIRC2	1	affinity chromatography technology	Salzmann S (2013)	1
RIPK2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	McCarthy JV (1998), Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	8
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
CD40LG	0	TRAF2	1	affinity chromatography technology	Salzmann S (2013)	1
XRCC5	5	HSPA4	3	biochemical	Kristensen AR (2012)	1
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
TRAF2	1	TDP2	2	affinity chromatography technology	Pype S (2000)	1
CD40	3	DDX3X	52	affinity chromatography technology	Ewing RM (2007)	1
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
TRAF2	1	CD40	3	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McWhirter SM (1999), Tsukamoto N (1999), Malinin NL (1997), Knox PG (2011), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Boucher LM (1997), Graham JP (2009), Deregibus MC (2003), Yacoub D (2010), Hostager BS (1999), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Rolland T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	21
TRAF3IP2	0	CD40	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian Y (2002), Qian Y (2004), Boisson B (2013)	3
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
IKBKB	1	TRAF1	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid	Sughra K (2010), Sughra K (2010), Sughra K (2010), Henkler F (2003)	4
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
TMEM173	0	CD40	3	affinity chromatography technology, affinity chromatography technology	Yao X (2016), Yao X (2016)	2
BAG3	4	POLR2H	0	affinity chromatography technology	Chen Y (2013)	1