PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BARD1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Dong Y (2003), Dong Y (2003), Feki A (2005), Jiang J (2011), Tembe V (2015), Tembe V (2015), Tembe V (2015)	7
BABAM2	2	MMS19	5	affinity chromatography technology	Sowa ME (2009)	1
BABAM2	2	FAS	2	affinity chromatography technology, affinity chromatography technology	Li Q (2004), Li Q (2004)	2
UIMC1	4	TP53	0	affinity chromatography technology, pull down	Yan J (2009), Yan J (2009)	2
BABAM2	2	SSR3	0	affinity chromatography technology	Sowa ME (2009)	1
COPS5	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei T (2017)	2
USP7	14	SUMO2	0	enzymatic study	Lecona E (2016)	1
USP7	14	WWP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Chaudhary N (2014)	2
MDC1	8	ABRAXAS1	0	affinity chromatography technology	Woods NT (2012)	1
DEF6	0	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
UIMC1	4	ABRAXAS2	1	affinity chromatography technology	Sowa ME (2009)	1
TNS2	3	BRCA1	7	two hybrid	Hill SJ (2014)	1
BABAM2	2	SLC25A13	1	affinity chromatography technology	Sowa ME (2009)	1
GFI1B	1	COPS5	0	two hybrid	Lim J (2006)	1
UBC	7	HNRNPA2B1	2	affinity chromatography technology	Matsumoto M (2005)	1
BABAM2	2	UGGT2	5	affinity chromatography technology	Sowa ME (2009)	1
BRCA2	6	BRCC3	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Kumaraswamy E (2007)	4
UBC	7	ABRAXAS1	0	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2009), Zhang X (2017)	3
BABAM2	2	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009)	17
PAXIP1	1	ABRAXAS1	0	affinity chromatography technology	Woods NT (2012)	1
WWP2	7	BRCC3	0	affinity chromatography technology	Chaudhary N (2014)	1
PAXIP1	1	BABAM1	1	affinity chromatography technology	Woods NT (2012)	1
NCOA3	3	BABAM2	2	two hybrid	Li C (2011)	1
BABAM2	2	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sowa ME (2009), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Zheng H (2013)	14
8339	0	BARD1	4	bioid	Lambert JP (2015)	1
BRCC3	0	UBE2D1	0	pull down	Dong Y (2003)	1
UBC	7	SLC25A13	1	affinity chromatography technology	Matsumoto M (2005)	1
8339	0	UIMC1	4	bioid	Lambert JP (2015)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
MDC1	8	BABAM2	2	affinity chromatography technology	Woods NT (2012)	1
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
MDC1	8	BABAM1	1	affinity chromatography technology	Woods NT (2012)	1
BABAM2	2	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Hu X (2011), Hu X (2011), Kristensen AR (2012), Zhang J (2014), Yan K (2015), Zheng H (2013)	8
BARD1	4	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down	Mallery DL (2002), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Nhukeaw T (2014), Thakar A (2010)	6
UBC	7	ABRAXAS2	1	pull down, pull down	Wang B (2009), Nathan JA (2013)	2
BARD1	4	RAD51	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Hu Y (2014)	3
ABRAXAS2	1	HNRNPA2B1	2	biochemical	Kristensen AR (2012)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
UIMC1	4	UBC	7	pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, unspecified method, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Sobhian B (2007), Sobhian B (2007), Wang B (2009), Hu X (2012), Sekiyama N (2012), Cho HJ (2009), Markin CJ (2010), Sekiyama N (2012), Sekiyama N (2012), Sato Y (2009), Sato Y (2009), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Guzzo CM (2012), Nathan JA (2013), Anamika A (2014), Kensche T (2012), Yan J (2007), Castaneda CA (2013), Nakasone MA (2013), Thach TT (2015), Zhang X (2017), Li Y (2017), Kristariyanto YA (2017)	25
BABAM2	2	TMX3	1	affinity chromatography technology	Sowa ME (2009)	1
WWP2	7	ABRAXAS2	1	affinity chromatography technology	Chaudhary N (2014)	1
COPS5	0	USP7	14	affinity chromatography technology	Bennett EJ (2010)	1
DEF6	0	BABAM1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	TFG	3	affinity chromatography technology	Ertych N (2016)	1
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
BRCA1	7	NCOA3	3	unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Rodriguez M (2003), Nakuci E (2006), Nakuci E (2006), Nakuci E (2006)	4
BABAM2	2	BRCA1	7	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Woods NT (2012), Hill SJ (2014)	5
BABAM2	2	RPN2	0	affinity chromatography technology	Sowa ME (2009)	1
BABAM1	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang B (2009), Shao G (2009), Shao G (2009), Shao G (2009), Bian C (2012), Hill SJ (2014)	6
BABAM2	2	SHMT2	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
BABAM2	2	TP53	0	affinity chromatography technology, affinity chromatography technology, biochemical	Dong Y (2003), Dong Y (2003), Dong Y (2003)	3
GFI1B	1	BABAM2	2	two hybrid	Lim J (2006)	1
MDC1	8	COPS5	0	two hybrid	Woods NT (2012)	1
BRCA1	7	RAD51	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scully R (1997), Dong Y (2003), Dong Y (2003), Dong Y (2003), Wang Q (2001), Chen J (1998), Mok MT (2010), Scully R (1997), Scully R (1997), Johnson N (2013), Jung YS (2014), Jung YS (2014), Parameswaran B (2015)	13
GRB2	2	BABAM2	2	affinity chromatography technology	Brehme M (2009)	1
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
BABAM2	2	ATG2A	8	affinity chromatography technology	Sowa ME (2009)	1
NCOA3	3	MMS19	5	two hybrid, pull down	Wu X (2001), Wu X (2001)	2
BRCC3	0	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang B (2007), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2010), Solyom S (2012), Zheng H (2013)	19
SUMO2	0	UIMC1	4	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Hu X (2012), Hu X (2012), Hu X (2012), Hu X (2012), Guzzo CM (2012), Guzzo CM (2012), Anamika (2016)	7
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
ABRAXAS1	0	BARD1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang B (2009), Feng L (2009), Hu Y (2014)	3
WWP2	7	DHRS7B	0	affinity chromatography technology	Chaudhary N (2014)	1
BRCA2	6	TP53	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Marmorstein LY (1998)	4
USP7	14	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Zhang J (2014), Zhang J (2014), Zhang J (2014)	4
BABAM2	2	FKBP8	1	affinity chromatography technology	Sowa ME (2009)	1
GRB2	2	HNRNPA2B1	2	affinity chromatography technology	Li J (2013)	1
WWP2	7	BABAM2	2	affinity chromatography technology	Chaudhary N (2014)	1
BRCA2	6	BARD1	4	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Dong Y (2003), Dong Y (2003), Ryser S (2009), Ryser S (2009), Kumaraswamy E (2007), Greenberg RA (2006)	6
8339	0	BABAM2	2	bioid	Lambert JP (2015)	1
BARD1	4	UIMC1	4	affinity chromatography technology, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009)	2
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
UIMC1	4	MDC1	8	imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, affinity chromatography technology	Strauss C (2011), Strauss C (2011), Strauss C (2011), Strauss C (2011), Strauss C (2011), Strauss C (2011), Woods NT (2012)	7
FKBP8	1	UBC	7	affinity chromatography technology	Nakagawa T (2007)	1
UBC	7	PHB	0	affinity chromatography technology	Matsumoto M (2005)	1
BABAM1	1	UGGT2	5	affinity chromatography technology	Sowa ME (2009)	1
BABAM1	1	SHMT2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
FAM189B	2	ABRAXAS2	1	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
BRCA2	6	RAD51	3	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sharan SK (1997), Lin HR (2003), Yu DS (2003), Yu DS (2003), Chen PL (1998), Chen PL (1998), Chen PL (1998), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sarkisian CJ (2001), Wong AK (1997), Wong AK (1997), Katagiri T (1998), Katagiri T (1998), Pellegrini L (2002), Tarsounas M (2004), Liu J (2001), Chen J (1998), Sharan SK (1997), Marmorstein LY (1998), Ohashi A (2005), Shivji MK (2006), Xia B (2006), Xia B (2006), Badie S (2010), Liu J (2010), Carreira A (2011), Chen CF (1999), Chen CF (1999), Chen CF (1999), Lee M (2011), Esashi F (2005), Esashi F (2005), Esashi F (2005), Thorslund T (2007), Thorslund T (2007), Esashi F (2007), Brough R (2012), Zhao W (2015), Chu WK (2015), Trego KS (2016), Trego KS (2016), Trego KS (2016), Trego KS (2016), Luo K (2016)	46
TNS2	3	BABAM2	2	affinity chromatography technology	Li X (2016)	1
PHB	0	SSR3	0	biochemical	Wan C (2015)	1
BABAM1	1	SLC25A13	1	affinity chromatography technology	Sowa ME (2009)	1
COPS5	0	BABAM2	2	affinity chromatography technology	Cooper EM (2009)	1
HNRNPL	3	BARD1	4	affinity chromatography technology	Fei T (2017)	1
EGFR	5	DHRS7B	0	affinity chromatography technology	Tong J (2014)	1
TP53	0	ABRAXAS2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2014), Zhang J (2014), Zhang J (2014), Huttlin EL (2015), Huttlin EL (2017)	5
BABAM2	2	OPTN	1	biochemical	Kristensen AR (2012)	1
BABAM2	2	TFG	3	biochemical	Kristensen AR (2012)	1
BABAM2	2	LRPPRC	7	affinity chromatography technology	Sowa ME (2009)	1
HNRNPL	3	TMX3	1	affinity chromatography technology	Fei T (2017)	1
BRCA2	6	BRCA1	7	affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sarkisian CJ (2001), Reuter TY (2003), Dong Y (2003), Chen J (1998), Chen J (1998), Villarroel MC (2011), Kumaraswamy E (2007), Sy SM (2009), Sy SM (2009), Sy SM (2009), Johnson N (2013), Hill SJ (2014), Loke J (2015)	13
AKAP2	0	BABAM2	2	biochemical	Kristensen AR (2012)	1
PAXIP1	1	UIMC1	4	affinity chromatography technology	Woods NT (2012)	1
SHMT2	3	LRPPRC	7	affinity chromatography technology	Castello A (2012)	1
BABAM2	2	RAD51	3	affinity chromatography technology, affinity chromatography technology, biochemical	Dong Y (2003), Dong Y (2003), Dong Y (2003)	3
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
GRB2	2	SLC25A13	1	affinity chromatography technology	Bisson N (2011)	1
TP53	0	LRPPRC	7	affinity chromatography technology, affinity chromatography technology	Lunardi A (2010), Fogeron ML (2013)	2
PAXIP1	1	MDC1	8	affinity chromatography technology	Woods NT (2012)	1
BRCA1	7	UIMC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Kim H (2007), Kim H (2007), Sobhian B (2007), Sobhian B (2007), Sowa ME (2009), Strauss C (2011), Strauss C (2011), Feng L (2009), Feng L (2009), Yan J (2007), Wang B (2007), Wang B (2007), Wang B (2007), Nikkilae J (2009), Nikkilae J (2009), Mok MT (2010), Johnson N (2013), Hill SJ (2014), Hu Y (2014), Hu Y (2014), Hu Y (2014), Renaud E (2016), Li Y (2017)	23
MMS19	5	RPN2	0	affinity chromatography technology	Stehling O (2012)	1
BRCA1	7	HNRNPA2B1	2	affinity chromatography technology, affinity chromatography technology	Goina E (2008), Ertych N (2016)	2
ABRAXAS1	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method	Wang B (2009), Shao G (2009), Hu X (2011), Feng L (2009), Wang B (2007), Wang B (2007), Liu Z (2007), Liu Z (2007), Nikkilae J (2009), Mok MT (2010), Kim H (2007), Kim H (2007), Kim H (2007), Solyom S (2012), Sevcik J (2013), Hill SJ (2014), Wu Q (2016), Wu Q (2016)	18
MDC1	8	BRCC3	0	affinity chromatography technology	Woods NT (2012)	1
HNRNPL	3	WWP2	7	affinity chromatography technology	Fei T (2017)	1
TP53	0	TTC28	6	genetic interference	Xie L (2013)	1
BABAM2	2	TTC28	6	affinity chromatography technology	Sowa ME (2009)	1
MDC1	8	TP53	0	affinity chromatography technology	Xu X (2003)	1
FAS	2	TNFRSF1A	3	biochemical	Gajate C (2005)	1
USP7	14	BRCC3	0	affinity chromatography technology	Sowa ME (2009)	1
BRCC3	0	ABRAXAS2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2010), Kristensen AR (2012), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	12
GRB2	2	TFG	3	two hybrid, affinity chromatography technology	Wang J (2008), Brehme M (2009)	2
EGFR	5	SLC25A13	1	affinity chromatography technology	Tong J (2014)	1
ABRAXAS2	1	SHMT2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Huttlin EL (2017), Zheng H (2013), Zheng H (2013), Zheng H (2013), Zheng H (2013)	5
UIMC1	4	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang B (2007), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2010), Wang B (2007), Wang B (2007), Liu Z (2007), Liu Z (2007), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Kim H (2007), Kim H (2007), Kim H (2007), Solyom S (2012), Cho HJ (2013), Hu Y (2014), Li Y (2017), Zheng H (2013)	30
SHMT2	3	UIMC1	4	affinity chromatography technology	Castello A (2012)	1
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
BABAM2	2	CHI3L1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SUMO2	0	MDC1	8	pull down	Ouyang J (2009)	1
BRCA2	6	BABAM2	2	affinity chromatography technology, biochemical, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003)	3
UBC	7	BABAM2	2	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2009), Zhang X (2017)	3
GRB2	2	BABAM1	1	affinity chromatography technology	Brehme M (2009)	1
TNS2	3	BABAM1	1	affinity chromatography technology	Li X (2016)	1
EGFR	5	MMS19	5	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
HNRNPL	3	BABAM2	2	affinity chromatography technology	Fei T (2017)	1
GRB2	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Hildt E (1999), Kurada BR (2009)	2
AKAP2	0	BABAM1	1	biochemical	Kristensen AR (2012)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
WWP2	7	UBE2D1	0	pull down, pull down	Kristariyanto YA (2015), Chen Z (2016)	2
PAXIP1	1	BRCC3	0	affinity chromatography technology	Woods NT (2012)	1
OPTN	1	UBC	7	affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down	Wild P (2011), Fenner BJ (2009), Zhu G (2007), Zhu G (2007), Wagner S (2008), Gleason CE (2011), Nagabhushana A (2011), Korac J (2012), Wild P (2011), Tumbarello DA (2015), Heo JM (2015), Ordureau A (2015), Richter B (2016), Richter B (2016), Nakazawa S (2016), Zhang X (2017), Kliza K (2017), Bansal M (2018)	18
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
FAM189B	2	BABAM1	1	affinity chromatography technology	Huttlin EL (2017)	1
BABAM1	1	ABRAXAS1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang B (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Bian C (2012), Solyom S (2012), Huttlin EL (2015), Huttlin EL (2017), Zheng H (2013)	20
BABAM2	2	PHB	0	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
BRCC3	0	TP53	0	affinity chromatography technology, affinity chromatography technology, biochemical	Dong Y (2003), Dong Y (2003), Dong Y (2003)	3
COPS5	0	HNRNPA2B1	2	affinity chromatography technology	Bennett EJ (2010)	1
MDC1	8	BARD1	4	affinity chromatography technology	Lou Z (2003)	1
UBC	7	TTC28	6	pull down	Nathan JA (2013)	1
SUMO2	0	BABAM2	2	affinity chromatography technology, pull down, affinity chromatography technology	Hu X (2012), Hu X (2012), Guzzo CM (2012)	3
BABAM2	2	UBE2D1	0	pull down	Dong Y (2003)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
EGFR	5	LRPPRC	7	affinity chromatography technology	Tong J (2014)	1
BABAM2	2	BARD1	4	affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003)	2
PHB	0	TP53	0	imaging technique, affinity chromatography technology, pull down	Fusaro G (2003), Fusaro G (2003), Fusaro G (2003)	3
TP53	0	HNRNPA2B1	2	affinity chromatography technology	Fogeron ML (2013)	1
SUMO2	0	BRCC3	0	pull down, affinity chromatography technology	Hu X (2012), Guzzo CM (2012)	2
UIMC1	4	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2007), Wang B (2007), Wang B (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Nikkilae J (2009), Wu J (2009), Shao G (2009), Cho HJ (2013)	17
EGFR	5	BABAM2	2	affinity chromatography technology	Liccardi G (2014)	1
BABAM2	2	HNRNPA2B1	2	biochemical	Kristensen AR (2012)	1
BABAM1	1	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hu X (2011), Hu X (2011), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	9
BRCC3	0	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017)	14
BABAM2	2	BABAM1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	21
GFI1B	1	TNS2	3	two hybrid	Lim J (2006)	1
GFI1B	1	BRCA1	7	two hybrid	Lim J (2006)	1
MDC1	8	RAD51	3	affinity chromatography technology, affinity chromatography technology, pull down	Zhang J (2005), Zhang J (2005), Zhang J (2005)	3
SUMO2	0	BRCA1	7	affinity chromatography technology	Hu X (2012)	1
GRB2	2	ABRAXAS2	1	affinity chromatography technology	Brehme M (2009)	1
HNRNPL	3	LRPPRC	7	affinity chromatography technology	Fei T (2017)	1
BRCA1	7	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down	Mallery DL (2002), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Morris JR (2006), Vandenberg CJ (2003), Morris JR (2006), Nhukeaw T (2014), Thakar A (2010)	14
TP53	0	NCOA3	3	pull down	Lee SK (1999)	1
BABAM1	1	TFG	3	biochemical	Kristensen AR (2012)	1
USP7	14	MMS19	5	biochemical	Kristensen AR (2012)	1
USP7	14	BABAM1	1	affinity chromatography technology	Sowa ME (2009)	1
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
HNRNPA2B1	2	HNRNPL	3	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hamilton BJ (1999), Havugimana PC (2012), Yao P (2013), Yao P (2013), Yao P (2013), Fei T (2017)	6
OPTN	1	TNFRSF1A	3	affinity chromatography technology	Klingseisen L (2012)	1
USP7	14	BABAM2	2	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	BRCC3	0	pull down, enzymatic study, pull down	Wang B (2009), Shao G (2009), Zhang X (2017)	3
TNS2	3	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
UIMC1	4	BABAM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Wu J (2009)	14
FAM189B	2	BABAM2	2	affinity chromatography technology	Huttlin EL (2017)	1
BRCC3	0	RAD51	3	affinity chromatography technology, affinity chromatography technology, biochemical	Dong Y (2003), Dong Y (2003), Dong Y (2003)	3
RAD51	3	TP53	0	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Stuerzbecher HW (1996), Stuerzbecher HW (1996), Buchhop S (1997), Nakai-Murakami C (2007), Yang Q (2004), Rasti M (2015), Rasti M (2015)	10
SUMO2	0	ABRAXAS1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hu X (2012), Hu X (2012), Guzzo CM (2012)	3
UIMC1	4	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017), Li Y (2017)	15
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
GRB2	2	BRCC3	0	affinity chromatography technology	Brehme M (2009)	1
BRCC3	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Kumaraswamy E (2007), Nikkilae J (2009), Woods NT (2012), Hill SJ (2014), Hu Y (2014)	8
BABAM2	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Li Q (2004), Li Q (2004)	2
8339	0	BRCA1	7	bioid	Lambert JP (2015)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
BRCC3	0	BARD1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Sobhian B (2007), Kumaraswamy E (2007), Kumaraswamy E (2007)	5
EGFR	5	FKBP8	1	protein complementation assay	Deribe YL (2009)	1
COPS5	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPL	3	DHRS7B	0	affinity chromatography technology	Fei T (2017)	1
RAD51	3	HNRNPA2B1	2	biochemical	Kristensen AR (2012)	1
BRCC3	0	SHMT2	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
BABAM2	2	DHRS7B	0	affinity chromatography technology	Sowa ME (2009)	1
COPS5	0	BRCC3	0	affinity chromatography technology	Cooper EM (2009)	1
DEF6	0	BABAM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	BABAM1	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
MDC1	8	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, imaging technique, imaging technique	Matsuoka S (2007), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Lou Z (2003), Mok MT (2010), Au WW (2005)	7
DEF6	0	BRCC3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAXIP1	1	BABAM2	2	affinity chromatography technology	Woods NT (2012)	1
COPS5	0	TFG	3	affinity chromatography technology	Bennett EJ (2010)	1