PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRSF2	0	U2AF1	0	two hybrid, two hybrid, two hybrid	Zhang WJ (1996), Hegele A (2012), Hegele A (2012)	3
NEK6	2	FANCI	1	affinity chromatography technology	Ewing RM (2007)	1
CIR1	1	RBM12	6	affinity chromatography technology	Huttlin EL (2017)	1
CIR1	1	SRSF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Maita H (2005), Maita H (2005), Maita H (2005)	3
AGO3	4	CIR1	1	affinity chromatography technology	Hein MY (2015)	1
CIR1	1	SAP30	1	two hybrid	Hsieh JJ (1999)	1
SNW1	0	NCOR2	12	affinity chromatography technology, two hybrid, two hybrid	Zhou S (2000), Zhou S (2000), Leong GM (2004)	3
CIR1	1	RP9	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Maita H (2005), Maita H (2005), Maita H (2005), Maita H (2005)	4
CIR1	1	CCNYL1	0	affinity chromatography technology	Huttlin EL (2017)	1
CIR1	1	UBR3	13	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	U2AF1	0	affinity chromatography technology	Lleres D (2010)	1
SNW1	0	SRSF2	0	affinity chromatography technology	Lleres D (2010)	1
CIR1	1	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
FANCI	1	CIR1	1	affinity chromatography technology	Hein MY (2015)	1
SRSF1	0	U2AF1	0	pull down, two hybrid, biochemical, two hybrid	Xiao SH (1998), Zhang WJ (1996), Havugimana PC (2012), Wang J (2011)	4
CIR1	1	DCAF10	2	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	FANCI	1	affinity chromatography technology	Lleres D (2010)	1
CIR1	1	GCA	0	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	SRSF1	0	affinity chromatography technology	Lleres D (2010)	1
SNW1	0	RBPJ	1	pull down, affinity chromatography technology, pull down, two hybrid	Zhou S (2000), Zhou S (2000), Zhou S (2000), Zhou S (2000)	4
CIR1	1	CTNNA2	6	affinity chromatography technology	Huttlin EL (2017)	1
RBPJ	1	CIR1	1	two hybrid	Hsieh JJ (1999)	1
RBPJ	1	NCOR2	12	two hybrid, two hybrid	Beatus P (2001), Zhou S (2001)	2
CIR1	1	EPHA2	3	affinity chromatography technology	Huttlin EL (2017)	1
CIR1	1	CDCA3	0	affinity chromatography technology	Huttlin EL (2017)	1
CIR1	1	U2AF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Maita H (2005), Maita H (2005), Maita H (2005), Maita H (2005)	4
CIR1	1	SRSF2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Maita H (2005), Maita H (2005), Maita H (2005)	3
CIR1	1	CEP76	1	two hybrid	Rolland T (2014)	1
U2AF1	0	RP9	0	two hybrid, pull down, affinity chromatography technology	Maita H (2004), Maita H (2004), Maita H (2004)	3
SNW1	0	CIR1	1	affinity chromatography technology, two hybrid, two hybrid	Zhou S (2000), Zhou S (2000), Zhou S (2000)	3
NEK6	2	CIR1	1	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
SRSF1	0	SRSF2	0	two hybrid, two hybrid, biochemical	Zhang WJ (1996), Zhang WJ (1996), Wan C (2015)	3
NCOR2	12	SAP30	1	biochemical	Underhill C (2000)	1
CIR1	1	NCOR2	12	two hybrid	Zhou S (2001)	1