PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CD3E	0	LCK	0	affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003)	2
CD38	0	CD247	1	affinity chromatography technology, biochemical	Munoz P (2003), Munoz P (2003)	2
CBL	7	ZAP70	5	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, x-ray crystallography	Lupher ML (1996), Meng W (1999), Wang HY (2001), Rao N (2000), Lupher ML (1997), Okabe S (2006), Zhang Z (1999), Lupher ML (1996), Dou H (2012), Dou H (2012), Gabrielsen M (2017)	11
CD38	0	FCGR3A	0	fluorescent resonance energy transfe	Deaglio S (2002)	1
LCK	0	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pelosi M (1999), Thome M (1995), Lupher ML (1996)	3
CD247	1	LCK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Yang M (2015)	3
LCK	0	CBL	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Rao N (2002), Tsygankov AY (1996), Reedquist KA (1996), Nervi S (2005)	4
CD38	0	ZAP70	5	biochemical	Munoz P (2003)	1
CD247	1	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mustelin T (1995), Wang HY (2001), La Face DM (1997), Huang H (2010), Huang H (2010), Hubert P (1996), Yang M (2015)	7
ZAP70	5	CD3E	0	pull down, affinity chromatography technology	Bu JY (1995), Hubert P (1996)	2
CD3E	0	CD247	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Munoz P (2003), Munoz P (2003), Chen TC (2014)	3
CD38	0	LCK	0	affinity chromatography technology	Munoz P (2003)	1
CD38	0	CD3E	0	affinity chromatography technology, biochemical	Munoz P (2003), Munoz P (2003)	2
CBL	7	CD247	1	affinity chromatography technology, affinity chromatography technology	Wang HY (2001), Wang HY (2001)	2
CBL	7	CD38	0	fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Shen M (2009), Shen M (2008), Shen M (2008)	3