PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MYOT	0	TFG	3	two hybrid	Wang J (2011)	1
MYOT	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TRIM55	2	FLNC	8	two hybrid	Witt CC (2008)	1
TRIM63	0	MYOT	0	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
GPRASP2	0	MYOT	0	two hybrid	Wang J (2011)	1
ST7	2	MYOT	0	two hybrid	Battle MA (2003)	1
MYOT	0	NME7	0	two hybrid	Rolland T (2014)	1
TRIM63	0	FLNC	8	two hybrid	Witt CC (2008)	1
MYOT	0	MYOT	0	two hybrid	van der Ven PF (2000)	1
MYOT	0	FLNC	8	affinity chromatography technology	van der Ven PF (2000)	1
TRIM55	2	MYOT	0	two hybrid	Witt CC (2008)	1
AXIN1	1	MYOT	0	two hybrid	Wang J (2011)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
AXIN1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down	Li Q (2011), Li Q (2011), He Y (2013), He Y (2013), He Y (2013), He Y (2013)	6
TP53	0	MYOT	0	genetic interference	Xie L (2013)	1
ACTN1	5	MYOT	0	affinity chromatography technology	Salmikangas P (2003)	1
TRIM63	0	APP	1	pull down	Olah J (2011)	1