PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP1LC3B	1	ATG3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Tanida I (2004), Gao W (2013)	3
WDFY3	17	ATG16L1	1	affinity chromatography technology	Filimonenko M (2010)	1
CAPN2	1	XPO1	8	biochemical	Kristensen AR (2012)	1
MEOX2	2	ATG5	0	two hybrid	Rolland T (2014)	1
MAP1LC3C	0	ATG16L1	1	affinity chromatography technology	Behrends C (2010)	1
IKBIP	2	ATG5	0	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	ATG12	1	affinity chromatography technology	Kirli K (2015)	1
EXOC4	2	ATG5	0	affinity chromatography technology	Bodemann BO (2011)	1
IKBIP	2	EXOC4	2	affinity chromatography technology	Huttlin EL (2017)	1
ATG12	1	ATG16L1	1	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Behrends C (2010)	2
TKT	2	VCP	6	biochemical	Wan C (2015)	1
ELAVL1	0	IKBIP	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ATG5	0	WDFY3	17	affinity chromatography technology, pull down	Filimonenko M (2010), Filimonenko M (2010)	2
RB1CC1	9	ATG5	0	affinity chromatography technology	Gammoh N (2013)	1
ATG5	0	CALCOCO2	0	pull down	Fracchiolla D (2016)	1
BCL2L1	0	ATG5	0	affinity chromatography technology	Yousefi S (2006)	1
ATG3	4	ATG5	0	affinity chromatography technology, pull down, affinity chromatography technology	Behrends C (2010), Qiu Y (2013), Huttlin EL (2017)	3
CALCOCO2	0	RB1CC1	9	two hybrid	Wang J (2011)	1
KEAP1	0	XPO1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaspar JW (2012), Kaspar JW (2012), Kirli K (2015)	3
CALCOCO2	0	SQSTM1	0	affinity chromatography technology	Cemma M (2011)	1
XPO1	8	ATG5	0	affinity chromatography technology	Kirli K (2015)	1
CAV1	0	ATG12	1	affinity chromatography technology, affinity chromatography technology	Chen ZH (2014), Chen ZH (2014)	2
ATG5	0	KEAP1	0	two hybrid	Rolland T (2014)	1
ATG3	4	ATG16L1	1	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
MAP1LC3B	1	SQSTM1	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Behrends C (2010), Vinayagam A (2011), Kirkin V (2009), Kirkin V (2009), Liang X (2013), Liang X (2013), Novak I (2010), Novak I (2010), Rogov VV (2012), Gao W (2013), Maruyama Y (2014), Maruyama Y (2014), Maruyama Y (2014), Yamashita SI (2014), Wurzer B (2015), Wurzer B (2015), Wurzer B (2015), Sun A (2017), Cohen-Kaplan V (2016), Dou Z (2015), Galindo-Moreno M (2017)	22
VCP	6	ATG5	0	two hybrid	Rolland T (2014)	1
ATG12	1	TECPR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Chen D (2012)	3
MAP1LC3B	1	ATG5	0	affinity chromatography technology	Behrends C (2010)	1
WIPI2	5	ATG5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dooley HC (2014), Huttlin EL (2015), Huttlin EL (2017)	3
OPTN	1	WIPI2	5	affinity chromatography technology, pull down	Bansal M (2018), Bansal M (2018)	2
CAPN2	1	ATG5	0	enzymatic study	Yousefi S (2006)	1
IKBIP	2	ATG16L1	1	affinity chromatography technology	Huttlin EL (2017)	1
EXOC4	2	ATG12	1	affinity chromatography technology	Bodemann BO (2011)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
ATG16L1	1	ATG5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, x-ray crystallography, two hybrid, pull down, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Chen D (2012), Chen D (2012), Ravikumar B (2010), Itoh T (2008), Kristensen AR (2012), Gammoh N (2013), Otomo C (2013), Wan C (2015), Kim JH (2014), Kim JH (2014), Kim JH (2014), Zheng Y (2017)	14
MAP1LC3C	0	ATG3	4	affinity chromatography technology	Behrends C (2010)	1
WIPI2	5	ATG12	1	affinity chromatography technology	Dooley HC (2014)	1
OPTN	1	MAP1LC3C	0	two hybrid	Tumbarello DA (2015)	1
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
MAP1LC3B	1	KEAP1	0	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3B	1	ATG16L1	1	affinity chromatography technology	Behrends C (2010)	1
CAV1	0	VCP	6	affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Kirchner P (2013), Kirchner P (2013), Chen SF (2013), Chen SF (2013)	4
ELAVL1	0	ATG5	0	affinity chromatography technology	Abdelmohsen K (2009)	1
XPO1	8	ATG16L1	1	affinity chromatography technology	Kirli K (2015)	1
ATG5	0	TKT	2	affinity chromatography technology	Behrends C (2010)	1
ELAVL1	0	ATG16L1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CALCOCO2	0	TAB3	1	affinity chromatography technology	Thurston TL (2009)	1
TAB3	1	ATG5	0	imaging technique	Takaesu G (2012)	1
HTT	14	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang H (2010), Yu CC (2013), Fujita K (2013), Fujita K (2013)	4
TKT	2	HTT	14	affinity chromatography technology	Huttlin EL (2017)	1
ATG5	0	CCHCR1	2	two hybrid	Rolland T (2014)	1
CAPN1	3	ATG5	0	enzymatic study	Yousefi S (2006)	1
TAB3	1	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011)	4
SQSTM1	0	MAP1LC3C	0	affinity chromatography technology	Kirkin V (2009)	1
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
XPO1	8	BCL10	0	affinity chromatography technology	Kirli K (2015)	1
KEAP1	0	SQSTM1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Jain A (2010), Jain A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Inami Y (2011), Fan W (2010), Copple IM (2010), Copple IM (2010), Wright T (2013), Tanji K (2013), Ichimura Y (2013), Ichimura Y (2013), Ichimura Y (2013), Hast BE (2014), Hast BE (2014), Lerner C (2013), Rolland T (2014), Gjyshi O (2015), Bakkar N (2015), Milan E (2015), Park S (2016), Ge W (2017), Mildenberger J (2017), Lu K (2017), Lee Y (2017)	30
ATG12	1	ATG5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Behrends C (2010), Behrends C (2010), Chen D (2012), Zheng Y (2017)	5
MAP1LC3B	1	CALCOCO2	0	affinity chromatography technology	Verlhac P (2015)	1
SQSTM1	0	CAV1	0	affinity chromatography technology, affinity chromatography technology	Liang X (2013), Luo X (2017)	2
BCL10	0	SQSTM1	0	affinity chromatography technology	Paul S (2012)	1
ATG5	0	TECPR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, biochemical, x-ray crystallography, two hybrid, pull down	Behrends C (2010), Behrends C (2010), Chen D (2012), Chen D (2012), Chen D (2012), Chen D (2012), Chen D (2012), Chen D (2012), Kim JH (2014), Kim JH (2014), Kim JH (2014)	11
XPO1	8	ATG3	4	affinity chromatography technology	Kirli K (2015)	1
BCL10	0	ATG5	0	affinity chromatography technology	Paul S (2012)	1
ATG5	0	OPTN	1	pull down, affinity chromatography technology, pull down	Fracchiolla D (2016), Bansal M (2018), Bansal M (2018)	3
ATG3	4	TECPR1	0	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010)	2
FADD	1	ATG12	1	affinity chromatography technology	Pyo JO (2005)	1
ATG5	0	SIRT1	3	affinity chromatography technology	Lee IH (2008)	1
CAV1	0	ATG5	0	affinity chromatography technology, affinity chromatography technology	Chen ZH (2014), Chen ZH (2014)	2
SQSTM1	0	TKT	2	pull down	Pridgeon JW (2004)	1
ATG5	0	TEKT4	1	two hybrid	Rolland T (2014)	1
TAB2	5	ATG5	0	imaging technique	Takaesu G (2012)	1
MAP1LC3C	0	CALCOCO2	0	affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology	von Muhlinen N (2012), von Muhlinen N (2012), von Muhlinen N (2012), Tumbarello DA (2015), Verlhac P (2015)	5
MAP1LC3C	0	WDFY3	17	affinity chromatography technology, pull down	Lystad AH (2014), Lystad AH (2014)	2
MAP1LC3C	0	RB1CC1	9	affinity chromatography technology	Behrends C (2010)	1
HTT	14	OPTN	1	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid	Faber PW (1998), Hattula K (2001), Hattula K (2001), Hattula K (2001), Suter B (2013)	5
ELAVL1	0	SIRT1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
OPTN	1	SQSTM1	0	affinity chromatography technology, pull down	Liu Z (2014), Liu Z (2014)	2
XPO1	8	TAB2	5	affinity chromatography technology	Kirli K (2015)	1
ELAVL1	0	BCL10	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ATG3	4	ATG12	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanida I (2002), Behrends C (2010), Behrends C (2010), Radoshevich L (2010), Qiu Y (2013), Huttlin EL (2017)	6
MAP1LC3C	0	ATG5	0	affinity chromatography technology	Behrends C (2010)	1
HTT	14	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Filimonenko M (2010), Zhou L (2014), Rui YN (2015), Rui YN (2015)	4
CAPN1	3	CAPN2	1	affinity chromatography technology	Huttlin EL (2017)	1
WDFY3	17	ATG12	1	affinity chromatography technology	Filimonenko M (2010)	1
SQSTM1	0	WDFY3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hocking LJ (2010), Clausen TH (2010), Clausen TH (2010), Isakson P (2013)	4
BSN	9	ATG5	0	affinity chromatography technology	Okerlund ND (2017)	1
ATG5	0	SQSTM1	0	pull down, affinity chromatography technology	Fracchiolla D (2016), Fracchiolla D (2016)	2
HTT	14	ATG5	0	affinity chromatography technology	Filimonenko M (2010)	1
WIPI2	5	ATG16L1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dooley HC (2014), Huttlin EL (2015), Huttlin EL (2017)	3
MAP1LC3B	1	OPTN	1	imaging technique, unspecified method, pull down, x-ray crystallography, affinity chromatography technology, pull down	Wild P (2011), Wild P (2011), Rogov VV (2013), Rogov VV (2013), Rogov VV (2013), Wild P (2011)	6
ATG5	0	FADD	1	pull down, affinity chromatography technology, imaging technique	Pyo JO (2005), Pyo JO (2005), Pyo JO (2005)	3
RB1CC1	9	ATG16L1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Fujita N (2013), Fujita N (2013), Gammoh N (2013), Gammoh N (2013), Gammoh N (2013), Gammoh N (2013), Dooley HC (2014)	7
OPTN	1	ATG16L1	1	affinity chromatography technology, pull down	Bansal M (2018), Bansal M (2018)	2
ATG5	0	IMPDH2	3	affinity chromatography technology	Ewing RM (2007)	1