PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MYC	2	AKAP6	6	affinity chromatography technology	Agrawal P (2010)	1
RYR2	26	AKAP6	6	biochemical, pull down	Marx SO (2000), Marx SO (2001)	2
CFTR	5	AKAP6	6	affinity chromatography technology	Wang X (2006)	1
CFTR	5	CALM1	0	affinity chromatography technology	Pankow S (2015)	1
CDC5L	2	AKAP6	6	two hybrid	Camargo LM (2007)	1
PRKAR2A	0	AKAP6	6	unspecified method	Alto NM (2003)	1
DISC1	6	CDC5L	2	two hybrid	Camargo LM (2007)	1
RYR2	26	PRKAR2A	0	biochemical	Marx SO (2000)	1
CFTR	5	RYR2	26	affinity chromatography technology	Wang X (2006)	1
PDE4D	4	AKAP6	6	affinity chromatography technology	Dodge KL (2001)	1
CALM1	0	CDC5L	2	pull down, affinity chromatography technology	Shen X (2005), Shen X (2005)	2
CALM1	0	RYR2	26	pull down, affinity chromatography technology	Nyegaard M (2012), Vassilakopoulou V (2015)	2
PRKAR2A	0	PDE4A	1	affinity chromatography technology, affinity chromatography technology	Dodge KL (2001), Dodge KL (2001)	2
AKAP6	6	PDE4A	1	affinity chromatography technology, affinity chromatography technology	Dodge KL (2001), Dodge KL (2001)	2
MYC	2	CALM1	0	affinity chromatography technology, pull down	Agrawal P (2010), Raffeiner P (2017)	2
DTNBP1	1	AKAP6	6	two hybrid	Camargo LM (2007)	1
CALM1	0	AKAP6	6	pull down	Shen X (2005)	1
DISC1	6	AKAP6	6	two hybrid	Camargo LM (2007)	1