PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XPO1	8	SH3BP5	0	affinity chromatography technology	Kirli K (2015)	1
ALB	1	APP	1	pull down	Olah J (2011)	1
MAPK9	3	MAPK10	0	affinity chromatography technology	Varjosalo M (2013)	1
SH3BP5	0	SYNE1	26	two hybrid	Camargo LM (2007)	1
MAPK9	3	MAPK8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
SH3BP5	0	DST	13	two hybrid	Camargo LM (2007)	1
DISC1	6	SPTBN1	6	two hybrid	Camargo LM (2007)	1
DISC1	6	SYNE1	26	affinity chromatography technology, two hybrid, two hybrid	Morris JA (2003), Morris JA (2003), Camargo LM (2007)	3
MOV10	6	SH3BP5	0	affinity chromatography technology	Castello A (2012)	1
LIMA1	4	SPTBN1	6	affinity chromatography technology	Hein MY (2015)	1
LIMA1	4	APP	1	pull down	Olah J (2011)	1
SH3BP5	0	BTK	1	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Matsushita M (1998), Matsushita M (1998), Yamadori T (1999), Yamadori T (1999)	4
NXF1	0	SH3BP5	0	affinity chromatography technology	Castello A (2012)	1
RAB11B	4	APP	1	pull down	Olah J (2011)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
DISC1	6	CDC5L	2	two hybrid	Camargo LM (2007)	1
ALB	1	SH3BP5	0	affinity chromatography technology	Zhou M (2004)	1
CDC5L	2	DST	13	two hybrid	Camargo LM (2007)	1
DISC1	6	DST	13	two hybrid	Camargo LM (2007)	1
DISC1	6	TNKS	12	two hybrid	Camargo LM (2007)	1
CDC5L	2	SYNE1	26	two hybrid	Camargo LM (2007)	1
EXOC1	3	SH3BP5	0	two hybrid	Camargo LM (2007)	1
LIMA1	4	SH3BP5	0	affinity chromatography technology	Hein MY (2015)	1
RAB11B	4	SH3BP5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SH3BP5	0	TNKS	12	two hybrid	Camargo LM (2007)	1
CDC5L	2	SPTBN1	6	two hybrid, affinity chromatography technology	Camargo LM (2007), Lleres D (2010)	2
NXF1	0	SPTBN1	6	biochemical	Wan C (2015)	1
DISC1	6	SH3BP5	0	two hybrid	Camargo LM (2007)	1
SH3BP5	0	SOS1	5	two hybrid	Camargo LM (2007)	1
NXF1	0	LIMA1	4	affinity chromatography technology	Castello A (2012)	1
MAPK8	3	APP	1	pull down, enzymatic study, pull down	Olah J (2011), Scheinfeld MH (2003), Scheinfeld MH (2003)	3
CDC5L	2	EXOC1	3	two hybrid, two hybrid	Camargo LM (2007), Camargo LM (2007)	2
SH3BP5	0	MAPK9	3	pull down	Wiltshire C (2002)	1
SH3BP5	0	APP	1	pull down	Olah J (2011)	1
SH3BP5	0	MAPK10	0	pull down	Wiltshire C (2002)	1
BTK	1	APP	1	pull down	Olah J (2011)	1
SH3BP5	0	MAPK8	3	pull down, two hybrid, enzymatic study, imaging technique	Wiltshire C (2002), Wiltshire C (2002), Wiltshire C (2002), Wiltshire C (2002)	4
SH3BP5	0	SPTBN1	6	two hybrid	Camargo LM (2007)	1
XPO1	8	TNKS	12	affinity chromatography technology	Kirli K (2015)	1
RAB11A	4	RAB11B	4	biochemical	Havugimana PC (2012)	1
MAPK10	0	APP	1	pull down	Olah J (2011)	1
MOV10	6	LIMA1	4	affinity chromatography technology	Castello A (2012)	1
EXOC1	3	DST	13	two hybrid	Camargo LM (2007)	1
RAB11A	4	SH3BP5	0	affinity chromatography technology	Huttlin EL (2017)	1
DISC1	6	EXOC1	3	two hybrid	Camargo LM (2007)	1
CDC5L	2	SH3BP5	0	two hybrid	Camargo LM (2007)	1
LIMA1	4	DST	13	affinity chromatography technology	Hein MY (2015)	1