PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HAND2	1	NPM1	0	two hybrid	Dai YS (2002)	1
TCF3	7	EP300	36	biochemical, affinity chromatography technology, enzymatic study, genetic interference, enzymatic study, pull down	Bradney C (2003), Bradney C (2003), Bradney C (2003), Bradney C (2003), Hyndman BD (2012), Kim JY (2004)	6
COPS5	0	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
HOXD13	0	HAND2	1	affinity chromatography technology, affinity chromatography technology	Galli A (2010), Galli A (2010)	2
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
PPP2R5D	29	HAND2	1	two hybrid, pull down	Firulli BA (2003), Firulli BA (2003)	2
DNMT3L	2	HAND2	1	pull down	Pacaud R (2014)	1
TCF3	7	HAND2	1	two hybrid	Dai YS (2002)	1
EP300	36	GATA4	4	affinity chromatography technology	Takaya T (2008)	1
TCF4	26	HAND2	1	two hybrid	Rolland T (2014)	1
TCF4	26	EP300	36	affinity chromatography technology	Li J (2007)	1
HAND2	1	HAND2	1	pull down	Dai YS (2002)	1
PRKACA	2	HAND2	1	enzymatic study	Firulli BA (2003)	1
PHOX2A	1	HAND2	1	pull down, affinity chromatography technology	Rychlik JL (2003), Rychlik JL (2003)	2
PRKCA	7	HAND2	1	enzymatic study	Firulli BA (2003)	1
NPM1	0	PRKCA	7	affinity chromatography technology	Chen R (2013)	1
GATA4	4	HAND2	1	pull down, affinity chromatography technology	Dai YS (2002), Dai YS (2002)	2
EP300	36	NPM1	0	enzymatic study	Swaminathan V (2005)	1
HAND2	1	COPS5	0	two hybrid	Dai YS (2002)	1
HAND2	1	EP300	36	pull down	Dai YS (2002)	1
PRKCA	7	EP300	36	enzymatic study, affinity chromatography technology	Yuan LW (2000), Rath S (2016)	2
HAND2	1	CENPB	0	two hybrid	Dai YS (2002)	1