PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRIK2	4	PICK1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Hirbec H (2003), Hirbec H (2003), Hirbec H (2003), Laezza F (2008)	4
GRIA3	2	GRIA4	4	affinity chromatography technology	Huttlin EL (2017)	1
PICK1	2	DSE	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	GPATCH2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRIA1	5	PICK1	2	pull down	Hirbec H (2002)	1
COIL	1	PICK1	2	two hybrid	Lim J (2006)	1
ERBIN	5	PICK1	2	two hybrid	Jaulin-Bastard F (2001)	1
PRKCA	7	PICK1	2	affinity chromatography technology	Dev KK (2000)	1
PICK1	2	AAED1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GFI1B	1	PICK1	2	two hybrid	Lim J (2006)	1
AKT1	1	PICK1	2	two hybrid	Arroyo R (2015)	1
PRKN	1	GRIK2	4	affinity chromatography technology	Maraschi A (2014)	1
ATXN7L3	0	ATXN7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao Y (2008), Zhao Y (2008), Janer A (2010), Lang G (2011), Huttlin EL (2015), Huttlin EL (2017), Li W (2016)	7
PRKCG	3	PICK1	2	two hybrid	Lim J (2006)	1
PICK1	2	GRIA3	2	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
ATXN7	0	PICK1	2	two hybrid	Lim J (2006)	1
PICK1	2	NDRG3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATXN3	2	PICK1	2	two hybrid	Lim J (2006)	1
ERBB2	6	PICK1	2	two hybrid, affinity chromatography technology	Jaulin-Bastard F (2001), Jaulin-Bastard F (2001)	2
EHD2	3	PICK1	2	two hybrid	Wang J (2011)	1
PRKN	1	SLC6A3	6	affinity chromatography technology	Jiang H (2004)	1
PICK1	2	QSOX2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GFI1	0	PICK1	2	two hybrid	Lim J (2006)	1
PRKCA	7	GRM7	8	affinity chromatography technology	Dev KK (2000)	1
CIC	9	PICK1	2	two hybrid	Lim J (2006)	1
SACS	15	PICK1	2	two hybrid	Lim J (2006)	1
PRKN	1	PICK1	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Joch M (2007), Joch M (2007), Joch M (2007), Joch M (2007)	4
PICK1	2	GNPTAB	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRLHR	0	PICK1	2	affinity chromatography technology	Lin SH (2001)	1
BIN3	1	PICK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	GPR37	3	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, genetic interference	Imai Y (2001), Imai Y (2001), Imai Y (2002), Imai Y (2002), Takahashi R (2003), Yang Y (2003)	6
SLC6A3	6	PICK1	2	two hybrid, affinity chromatography technology	Torres GE (2001), Torres GE (2001)	2
TCP10L	0	PICK1	2	affinity chromatography technology	Huttlin EL (2017)	1
DPEP1	1	ILVBL	4	affinity chromatography technology	Huttlin EL (2017)	1
ASIC1	2	PICK1	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Leonard AS (2003), Hruska-Hageman AM (2002), Hruska-Hageman AM (2002)	3
USP7	14	PICK1	2	two hybrid	Lim J (2006)	1
ATXN1L	0	PICK1	2	two hybrid	Lim J (2006)	1
EFNB2	0	EFNB1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKCA	7	PRKCG	3	affinity chromatography technology	Huttlin EL (2017)	1
PRKCG	3	GRIA4	4	affinity chromatography technology, pull down	Correia SS (2003), Correia SS (2003)	2
APTX	3	PICK1	2	two hybrid	Lim J (2006)	1
PICK1	2	PKD2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	EPHA7	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	KLHL11	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	NFS1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FXN	0	PICK1	2	two hybrid	Lim J (2006)	1
GRM3	0	PICK1	2	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
ATXN3	2	ASIC1	2	two hybrid	Shen L (2005)	1
PICK1	2	GRIA2	4	two hybrid, pull down, pull down	Hirbec H (2002), Hirbec H (2002), Dutta P (2014)	3
ATXN7L3	0	PICK1	2	two hybrid	Lim J (2006)	1
PICK1	2	ATP11A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	ZNF24	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRIK2	4	GRIA1	5	affinity chromatography technology	Wenthold RJ (1994)	1
RASSF7	0	PICK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	ITGA6	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	LDB1	2	affinity chromatography technology	Huttlin EL (2017)	1
PICK1	2	FAM117A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DPEP1	1	ASIC1	2	affinity chromatography technology	Huttlin EL (2017)	1
PICK1	2	EFNB2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	ATP6AP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLHL24	1	PICK1	2	affinity chromatography technology	Laezza F (2008)	1
GRIK1	9	PICK1	2	two hybrid, pull down, affinity chromatography technology	Hirbec H (2003), Hirbec H (2003), Hirbec H (2003)	3
ATP6AP2	2	PICK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	NECTIN2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP6AP1	0	GFI1B	1	genetic interference	Horlbeck MA (2018)	1
GRIK2	4	GRIA2	4	affinity chromatography technology	Wenthold RJ (1994)	1
GRIA1	5	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Leuschner WD (1999), Correia SS (2008)	2
PICK1	2	ARFIP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	FHOD1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	UGCG	0	affinity chromatography technology	Huttlin EL (2015)	1
GRM7	8	PICK1	2	two hybrid, pull down, affinity chromatography technology, enzymatic study, two hybrid, pull down	Dev KK (2000), Dev KK (2000), Dev KK (2000), Dev KK (2000), Hirbec H (2002), Hirbec H (2002)	6
GRIA4	4	GRIA1	5	affinity chromatography technology	Ripellino JA (1998)	1
RASSF7	0	GNPTAB	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATXN1L	0	COIL	1	two hybrid	Lim J (2006)	1
ERBIN	5	ERBB2	6	pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Jaulin-Bastard F (2001), Jaulin-Bastard F (2001), Jaulin-Bastard F (2001), Jaulin-Bastard F (2001), Borg JP (2000), Borg JP (2000), Huang YZ (2003)	7
PICK1	2	ILVBL	4	affinity chromatography technology	Huttlin EL (2017)	1
PICK1	2	GRIA4	4	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
PRKN	1	ATXN3	2	pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography	Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Bai JJ (2013)	7
PICK1	2	AMIGO1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	UACA	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP6AP2	2	ATP6AP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
PICK1	2	EFNB1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERBB2	6	ATP6AP1	0	two hybrid	Arroyo R (2015)	1
PICK1	2	F11R	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	BNC1	2	two hybrid, affinity chromatography technology	Hruska-Hageman AM (2002), Hruska-Hageman AM (2002)	2
MAGEA1	0	PICK1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PICK1	2	ICA1L	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERBB2	6	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBQLN4	2	PICK1	2	two hybrid	Lim J (2006)	1
PICK1	2	ICA1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DPEP1	1	PICK1	2	affinity chromatography technology	Huttlin EL (2017)	1
PICK1	2	CEP89	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GPR37	3	PICK1	2	two hybrid, pull down, affinity chromatography technology	Dutta P (2014), Dutta P (2014), Dutta P (2014)	3