PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
TP53INP1	0	HIPK2	0	pull down, pull down, affinity chromatography technology	Tomasini R (2003), Tomasini R (2003), Tomasini R (2003)	3
TP53	0	ASPM	9	affinity chromatography technology	Lunardi A (2010)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
TP53INP1	0	KAT14	2	affinity chromatography technology	Huttlin EL (2017)	1
TP53INP1	0	ZBTB9	0	affinity chromatography technology	Huttlin EL (2017)	1
TP53INP1	0	GABARAP	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Seillier M (2012), Seillier M (2012), Seillier M (2012)	3
TP53INP1	0	GABARAPL2	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Seillier M (2012), Seillier M (2012), Seillier M (2012)	3
HNRNPL	3	TBC1D4	6	affinity chromatography technology	Fei T (2017)	1
TP53INP1	0	ASPM	9	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	GABARAPL2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPL	3	HIPK2	0	affinity chromatography technology	Fei T (2017)	1
GABARAP	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
HNRNPL	3	TP53INP1	0	affinity chromatography technology	Fei T (2017)	1
TP53	0	HIPK2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Kim EJ (2002), Sung KS (2005), Li Q (2011), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), Lee MG (2014), Mancini F (2016)	12
HNRNPL	3	YEATS2	1	affinity chromatography technology	Fei T (2017)	1
GABARAP	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Behrends C (2010), Kirkin V (2009), Maruyama Y (2014), Dunlop EA (2014), Wurzer B (2015), Wurzer B (2015)	6
SQSTM1	0	GABARAPL2	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Behrends C (2010), Vinayagam A (2011), Shvets E (2011), Kirkin V (2009), Kirkin V (2009), Maruyama Y (2014), Rolland T (2014), Yu H (2011)	9
MAP1LC3A	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, affinity chromatography technology	Shvets E (2008), Shvets E (2008), Behrends C (2010), Gao Z (2010), Pan JA (2011), Pankiv S (2007), Pankiv S (2007), Shvets E (2011), Tung YT (2010), Bjorkoy G (2005), Kirkin V (2009), Lim J (2011), Lim J (2011), Pan JA (2012), Lee DY (2013), Wang BS (2013), Wang BS (2013), Sansanwal P (2012), Shi J (2013), Fujita N (2013), Chen X (2014), Liu XD (2014), Noda NN (2008), Noda NN (2008), Matsuzawa Y (2015), Matsuzawa Y (2015), Rui YN (2015), Rui YN (2015), Ciuffa R (2015), Wang N (2013), Hua F (2015), Rui YN (2015), Cha-Molstad H (2015), Paul S (2012), Puvirajesinghe TM (2016), Wang L (2017), Cha-Molstad H (2017), Peng H (2017), Lee Y (2017)	39
TP53INP1	0	SQSTM1	0	fluorescent resonance energy transfe	Seillier M (2012)	1
TP53	0	SQSTM1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Lello P (2006), Horikawa I (2014), Kang JH (2016), Kang JH (2016)	4
TP53	0	TBC1D4	6	affinity chromatography technology	Fogeron ML (2013)	1
TP53INP1	0	MAP1LC3A	0	affinity chromatography technology, fluorescent resonance energy transfe	Seillier M (2012), Seillier M (2012)	2
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53INP1	0	TP53	0	pull down, pull down, affinity chromatography technology, pull down	Tomasini R (2003), Tomasini R (2003), Tomasini R (2003), Okamura S (2001)	4
TP53INP1	0	TBC1D4	6	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	TP53INP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
YEATS2	1	KAT14	2	affinity chromatography technology	Wang YL (2008)	1
TP53INP1	0	YEATS2	1	affinity chromatography technology	Huttlin EL (2017)	1