Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
NRXN1	rs4971678	T	duloxetine	efficacy	yes	Variant was suggestively significant, but did not reach genome-wide significance. Response was defined by >50% decrease in Montgomery-Asberg Depression Rating Scale (MADRS) score at the end of treatment.	Allele T is associated with decreased response to duloxetine in people with Depressive Disorder, Major as compared to allele A.	29407288	1449167736
NRXN1	rs12467557	AA	antipsychotics	efficacy	yes	Patients homozygous for the A allele had significant improvement in positive symptoms (p=0.002), general psychopathology (p=0.005), thought disturbance (p=0.005), activation (p=0.005) and negative symptoms (p=0.005), while patients carrying the G allele showed no overall response. No significant results were seen for anergia (p=0.0505), paranoid belligerence (p=0.1212) or depression (p=0.1183). Additionally, no significant results were seen when the associations for positive and negative symptoms and general psychopathology were tested for replication in a different cohort (CATIE study).	Genotype AA is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotypes AG + GG.	24633560	1447674758
NRXN1	rs10490162	TT	antipsychotics	efficacy	yes	Patients homozygous for the T allele had significant improvement in positive symptoms (p=0.0045), general psychopathology (p=0.0146), thought disturbance (p=0.0029), activation (p=0.008), anergia (p=0.0266) and negative symptoms (p=0.0047), while patients carrying the C allele showed no overall response. No significant results were seen for paranoid belligerence (p=0.1598) or depression (p=0.1869). Additionally, no significant results were seen when the associations for positive and negative symptoms and general psychopathology were tested for replication in a different cohort (CATIE study). Please note that alleles have been complemented to the plus chromosomal strand.	Genotype TT is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotypes CC + CT.	24633560	1447674771