PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMAD2	5	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xi Q (2008), Xi Q (2008), Xi Q (2008), He W (2006)	4
SMAD2	5	MYOCD	4	pull down	Qiu P (2005)	1
PTPA	0	MYOCD	4	affinity chromatography technology	Glatter T (2009)	1
MKL1	2	SRF	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Selvaraj A (2003), Zhang M (2007), Zhang M (2007), Charbonney E (2011), Philippar U (2004)	5
MYOCD	4	MYOD1	0	pull down	Long X (2007)	1
NCOA3	3	MKL1	2	pull down	Li HJ (2007)	1
STUB1	4	MYOCD	4	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, enzymatic study	Xie P (2009), Xie P (2009), Xie P (2009), Xie P (2009), Xie P (2009)	5
SMAD3	1	MYOCD	4	affinity chromatography technology, pull down	Qiu P (2005), Qiu P (2005)	2
SMAD3	1	NCOA3	3	affinity chromatography technology	Xi Q (2008)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
MYOCD	4	MKL1	2	pull down	Du KL (2004)	1
ARRB2	5	STUB1	4	affinity chromatography technology	Zhang Z (2009)	1
SMAD2	5	HSPA4	3	affinity chromatography technology	Brown KA (2008)	1
MYOCD	4	HSP90AA1	7	affinity chromatography technology	Xie P (2009)	1
MKL1	2	SMAD3	1	affinity chromatography technology	Charbonney E (2011)	1
SMARCA4	19	MYOCD	4	affinity chromatography technology, affinity chromatography technology, pull down	Zhou J (2009), Zhou J (2009), Zhou J (2009)	3
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
SMAD2	5	STUB1	4	pull down	Li L (2004)	1
STUB1	4	HSPA4	3	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Dai Q (2005), Tateishi Y (2004), Tateishi Y (2004), Ko HS (2009), Qian SB (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Wang L (2011), Wang L (2011), Graf C (2010), Kundrat L (2010), Matsumoto K (2011), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Luo W (2010), Soss SE (2011), Zhou P (2003), Kalia LV (2011), Gao Y (2010), Gao Y (2010), Grelle G (2006), Rao SN (2010), Tetzlaff JE (2008), Kim SA (2005), Dai Q (2003), Zhang X (2011), Zhang X (2011), Muller P (2012), Jang KW (2011), Schuelke JP (2010), Jinwal UK (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Mao RF (2013), Lee JS (2013), Lee JS (2013)	42
KDM3A	11	MKL1	2	pull down, pull down	Lockman K (2007), Lockman K (2007)	2
SMAD3	1	STUB1	4	pull down	Li L (2004)	1
ARRB2	5	MYOCD	4	affinity chromatography technology	Xiao K (2007)	1
SMAD3	1	HSPA4	3	affinity chromatography technology	Brown KA (2008)	1
SMARCA4	19	SRF	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou J (2009), Zhou J (2009), Zhang M (2007)	3
GOPC	5	MYOCD	4	two hybrid	Rolland T (2014)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
KDM3A	11	MYOCD	4	pull down	Lockman K (2007)	1
SMAD3	1	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), Xi Q (2008)	2
HSP90AA1	7	MYOD1	0	pull down	Shaknovich R (1992)	1
MKL1	2	SMARCA4	19	affinity chromatography technology, pull down	Zhang M (2007), Zhang M (2007)	2
MYOCD	4	NCOA3	3	affinity chromatography technology, affinity chromatography technology, genetic interference, pull down, genetic interference	Li HJ (2007), Li HJ (2007), Li HJ (2007), Li HJ (2007), Li HJ (2007)	5
MYOCD	4	SRF	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Z (2004), Zhou J (2009), Zhou J (2009), Li HJ (2007)	4
MYOCD	4	HSPA4	3	affinity chromatography technology	Xie P (2009)	1
SMAD2	5	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), He W (2006)	2
MYOD1	0	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Philipot O (2010), de la Serna IL (2005), Forcales SV (2012)	3
ARRB2	5	PTPA	0	affinity chromatography technology	Kendall RT (2011)	1