PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VPS37C	3	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
EYA4	1	MAPK1IP1L	0	affinity chromatography technology	Li X (2016)	1
EWSR1	2	MAPK1IP1L	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Wang J (2011), Rolland T (2014)	3
MTMR14	4	MAPK1IP1L	0	affinity chromatography technology	Li X (2016)	1
PTPDC1	3	MAPK1IP1L	0	affinity chromatography technology	Li X (2016)	1
SCLT1	1	MAPK1IP1L	0	bioid	Gupta GD (2015)	1
PDCD6	2	MAPK1IP1L	0	two hybrid	Rual JF (2005)	1
SUMO1	0	391257	0	two hybrid	Rolland T (2014)	1
EGLN3	0	LENG8	2	affinity chromatography technology	Rodriguez J (2016)	1
TFG	3	CEP55	2	two hybrid	Rolland T (2014)	1
PDCD6	2	HNRNPUL1	1	biochemical	Wan C (2015)	1
EWSR1	2	TFG	3	two hybrid, bioid	Rolland T (2014), Elzi DJ (2014)	2
EGLN3	0	EYA4	1	affinity chromatography technology	Rodriguez J (2016)	1
PTPN5	0	MAPK1IP1L	0	affinity chromatography technology	Li X (2016)	1
HNRNPUL1	1	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
PTPN7	3	MAPK1IP1L	0	affinity chromatography technology	Li X (2016)	1
EWSR1	2	CEP55	2	bioid	Elzi DJ (2014)	1
EGLN3	0	MTMR14	4	affinity chromatography technology	Rodriguez J (2016)	1
RBFOX2	5	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
PDCD6	2	VPS37C	3	two hybrid	Rolland T (2014)	1
EGLN3	0	RBFOX2	5	affinity chromatography technology	Rodriguez J (2016)	1
EWSR1	2	SUMO1	0	bioid	Elzi DJ (2014)	1
TFG	3	VPS37C	3	two hybrid	Rolland T (2014)	1
CDC25B	4	MAPK1IP1L	0	affinity chromatography technology	Li X (2016)	1
TFG	3	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
UBE2I	0	391257	0	two hybrid	Rolland T (2014)	1
PTPRR	3	MAPK1IP1L	0	affinity chromatography technology	Li X (2016)	1
EWSR1	2	HNRNPUL1	1	two hybrid	Wang J (2011)	1
HGS	5	CEP55	2	two hybrid	Morita E (2007)	1
LENG8	2	MAPK1IP1L	0	two hybrid	Venkatesan K (2009)	1
UBE2I	0	HGS	5	two hybrid	Rual JF (2005)	1
MTMR3	8	MAPK1IP1L	0	affinity chromatography technology	Li X (2016)	1
MAPK1IP1L	0	391257	0	two hybrid	Rolland T (2014)	1
TFG	3	ARHGEF16	1	two hybrid	Rolland T (2014)	1
RBFOX2	5	C1orf94	1	two hybrid	Rolland T (2014)	1
CEP152	2	MAPK1IP1L	0	bioid	Gupta GD (2015)	1
PDCD6	2	TFG	3	affinity chromatography technology	McGourty CA (2016)	1
CEP55	2	VPS37C	3	affinity chromatography technology, two hybrid, two hybrid	Morita E (2007), Morita E (2007), Rolland T (2014)	3
VPS37C	3	C1orf94	1	two hybrid	Rolland T (2014)	1
SUMO1	0	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
EGLN3	0	MTMR3	8	affinity chromatography technology	Rodriguez J (2016)	1
SS18L1	2	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
EGLN3	0	MAPK1IP1L	0	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPUL1	1	VPS37C	3	two hybrid	Rolland T (2014)	1
ARHGEF16	1	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
MAPK1IP1L	0	MAPK1IP1L	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CEP55	2	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
UBE2I	0	MAPK1IP1L	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
C1orf94	1	MAPK1IP1L	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
VPS37C	3	HGS	5	two hybrid, two hybrid	Eastman SW (2005), Rolland T (2014)	2
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
SUMO1	0	HGS	5	two hybrid	Rolland T (2014)	1
EIF3E	1	MAPK1IP1L	0	two hybrid	Yu H (2011)	1
HGS	5	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1