PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MED10	0	MED11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Sato S (2003), Zhang X (2005), Havugimana PC (2012), Wan C (2015)	7
TRIP4	2	MED8	0	affinity chromatography technology	Malovannaya A (2010)	1
NFKB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Deng WG (2003), Deng WG (2003), Furia B (2002), Wang H (2010), Wang H (2010), Sen GS (2011), Hassa PO (2003), Hassa PO (2003), Deng WG (2003)	9
PPARG	0	CREBBP	29	pull down, two hybrid, unspecified method, pull down, two hybrid, pull down, unspecified method	Li M (2000), Chen Q (2004), Lee G (2002), Carmona MC (2007), Carmona MC (2007), Jeninga EH (2007), Koppen A (2009)	7
MED28	2	5430	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Malovannaya A (2010)	2
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
PPARG	0	KIF11	5	unspecified method	Koppen A (2009)	1
MED4	2	KIF11	5	bioid	Lambert JP (2015)	1
TRIP4	2	MED10	0	affinity chromatography technology	Malovannaya A (2010)	1
ESR2	1	MED23	3	pull down	Kang YK (2002)	1
MED28	2	MED13	11	affinity chromatography technology, pull down, affinity chromatography technology	Sato S (2004), Zhang X (2005), Malovannaya A (2010)	3
RARA	5	MED25	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Lee HK (2007), Lee HK (2007), Lee HK (2007), Lee HK (2007)	4
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
MED12	11	MED24	4	affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Hein MY (2015)	3
PPARG	0	MED1	4	fluorescent resonance energy transfe, pull down, two hybrid, pull down, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, unspecified method, pull down, pull down, two hybrid, unspecified method	Iannone MA (2001), Yang W (2000), Shao G (2000), Treuter E (1999), Albers M (2005), Feige JN (2007), Feige JN (2007), Qin C (2004), Lee G (2002), Agostini M (2006), Carmona MC (2007), Carmona MC (2007), Koppen A (2009)	13
MED1	4	MED24	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, genetic interference	Yuan CX (1998), Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Horlbeck MA (2018)	8
NTRK1	1	RELA	1	affinity chromatography technology	Emdal KB (2015)	1
MED25	1	MED17	0	affinity chromatography technology, affinity chromatography technology	Mittler G (2003), Mittler G (2003)	2
MED1	4	MED23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, genetic interference	Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Lambert JP (2015), Huttlin EL (2017), Horlbeck MA (2018)	6
MED15	6	MED24	4	biochemical	Wan C (2015)	1
MED8	0	MED27	0	biochemical	Wan C (2015)	1
MED13	11	MED27	0	biochemical	Wan C (2015)	1
NCOA1	6	TRIP4	2	two hybrid, pull down	Kim HJ (1999), Kim HJ (1999)	2
ASCC1	0	TRIP4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
SRF	1	CREBBP	29	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Ramirez S (1997), Ramirez S (1997)	4
TRIP4	2	MED27	0	affinity chromatography technology	Malovannaya A (2010)	1
TRIP4	2	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
UBC	7	ASCC2	3	pull down	Zhang X (2017)	1
CREBBP	29	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, genetic interference, genetic interference, genetic interference, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Jang HD (2004), Zhong H (2002), Zhong H (2002), Parry GC (1997), Parry GC (1997), Parry GC (1997), Aarnisalo P (1998), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Liu GH (2008), Vanden Berghe W (1999), Naeaer AM (1999), Merika M (1998), Park J (2007), Verma UN (2004), Verma UN (2004), Verma UN (2004), Johnson J (2007), Aksoy E (2007), Azran I (2005), Silverman ES (1998), Huang WC (2007), Huang WC (2007), Aarnisalo P (1998), Kim HJ (1999), Hsu DS (2014), Chen Y (2015), Huang SM (2002)	30
MED1	4	5430	0	affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Huttlin EL (2017)	2
ESR1	0	MED23	3	affinity chromatography technology, pull down	Kang YK (2002), Kang YK (2002)	2
EP300	36	ESR1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Fajas L (2002), Fan S (2002), Fan S (2002), Fan S (2002), Kang YK (2002), Kang YK (2002), Hao L (2010), Jin W (2008), Cui Y (2006), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Kim SH (2010), Ma Y (2010), Ma Y (2010), Fujita T (2003), Likhite VS (2004), Band AM (2011), Loven MA (2004), Nalvarte I (2010), Yi P (2015)	21
MED10	0	MED1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Sato S (2004), Tomomori-Sato C (2004), Zhang X (2005), Zhang X (2005), Zhang X (2005), Zhang X (2005), Malik S (2000), Huttlin EL (2017), Horlbeck MA (2018)	9
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
MED15	6	MED13	11	affinity chromatography technology	Mittler G (2003)	1
MED8	0	MED17	0	biochemical	Wan C (2015)	1
MED28	2	MED25	1	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Malovannaya A (2010)	2
MED15	6	MED27	0	biochemical	Wan C (2015)	1
TRIP4	2	MED1	4	affinity chromatography technology	Malovannaya A (2010)	1
EP300	36	RXRA	1	affinity chromatography technology, affinity chromatography technology	Zhao WX (2007), Zhao WX (2007)	2
ESR2	1	MED17	0	pull down, affinity chromatography technology	Kang YK (2002), Nassa G (2011)	2
NTRK1	1	MED1	4	affinity chromatography technology	Emdal KB (2015)	1
RELA	1	JUN	0	two hybrid, genetic interference	Yang X (1999), Yang X (1999)	2
MED10	0	MED12	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sato S (2004), Sato S (2004), Zhang X (2005), Malovannaya A (2010), Malik S (2000), Wan C (2015), Hein MY (2015)	7
MED12	11	MED11	0	affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Hein MY (2015)	3
MED17	0	MED24	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MED11	0	MED8	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TRIP4	2	RCOR1	0	affinity chromatography technology	Malovannaya A (2010)	1
NTRK1	1	KIF11	5	affinity chromatography technology	Emdal KB (2015)	1
MED11	0	MED24	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
XPO1	8	5430	0	affinity chromatography technology	Kirli K (2015)	1
MED11	0	MED17	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
EP300	36	5430	0	affinity chromatography technology, affinity chromatography technology	Cho H (1998), Fousteri M (2006)	2
TRIP4	2	MED11	0	affinity chromatography technology	Malovannaya A (2010)	1
SRF	1	TRIP4	2	pull down, pull down, two hybrid	Jung DJ (2002), Jung DJ (2002), Jung DJ (2002)	3
NR2F2	4	TRIP4	2	two hybrid	Ravasi T (2010)	1
TRIP4	2	MED17	0	affinity chromatography technology	Malovannaya A (2010)	1
RELA	1	UBC	7	affinity chromatography technology	Schweitzer K (2015)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
ASCC1	0	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
ESR1	0	NCOA1	6	pull down, pull down, pull down, pull down, two hybrid, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	DiRenzo J (2000), Sheppard HM (2001), Kalkhoven E (1998), Kang YK (2002), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Tremblay A (2001), Llopis J (2000), Chien PY (1999), Webb P (1998), Webb P (1998), Lazennec G (1997), Heery DM (1997), Heery DM (1997), Torchia J (1997), Torchia J (1997), Fleming FJ (2004), Fujita T (2003), Fujita T (2003), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Kraichely DM (2000), Kraichely DM (2000), Gong EY (2010), Eng FC (1998), Needham M (2000), Needham M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Albers M (2005), Kurtev V (2004), DiRenzo J (1997), Han SJ (2016), Han SJ (2016)	37
ESR1	0	CREBBP	29	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Sheppard HM (2001), Fan S (2002), Fan S (2002), Fan S (2002), Jin W (2008), Jaber BM (2004), Jaber BM (2004), Heery DM (1997), Ku TK (2007), Crowe DL (2006)	10
NTRK1	1	XPO1	8	affinity chromatography technology	Emdal KB (2015)	1
ESR1	0	MED12	11	affinity chromatography technology, pull down, affinity chromatography technology	Kang YK (2002), Kang YK (2002), Han SJ (2016)	3
ESR1	0	XBP1	2	pull down, affinity chromatography technology	Ding L (2003), Ding L (2003)	2
NTRK1	1	ASCC2	3	affinity chromatography technology	Emdal KB (2015)	1
CREBBP	29	NCOA1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Sheppard HM (2001), Sheppard HM (2001), Sheppard HM (2001), Wu RC (2002), Torchia J (1997), Torchia J (1997), Matsuda S (2004), DiRenzo J (2000), Nakuci E (2006), Ruas JL (2005), Huang SM (2002)	11
PAX9	0	TRIP4	2	two hybrid	Ravasi T (2010)	1
MED23	3	MED17	0	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
MED1	4	MED15	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Mittler G (2003), Wan C (2015), Huttlin EL (2017)	6
MED25	1	RXRA	1	two hybrid, pull down, affinity chromatography technology	Lee HK (2007), Lee HK (2007), Lee HK (2007)	3
ESR2	1	TRIP4	2	fluorescent resonance energy transfe	Iannone MA (2001)	1
RARA	5	MED1	4	affinity chromatography technology, pull down, fluorescent resonance energy transfe, two hybrid, x-ray crystallography	Llopis J (2000), Llopis J (2000), Llopis J (2000), Lee HK (2007), Rochel N (2011)	5
5430	0	RELA	1	imaging technique	Freaney JE (2013)	1
XPO1	8	RELA	1	affinity chromatography technology	Kirli K (2015)	1
MED24	4	MED8	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MED10	0	MED13	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Zhang X (2005), Zhang X (2005), Malik S (2000), Wan C (2015)	5
MED23	3	5430	0	bioid	Lambert JP (2015)	1
MED10	0	MED25	1	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Zhang X (2005)	2
RELA	1	RXRA	1	pull down, imaging technique, pull down	Na SY (1999), Chen TC (2014), Gu X (2006)	3
EP300	36	TRIP4	2	two hybrid	Kim HJ (1999)	1
NEK6	2	TRIP4	2	two hybrid, pull down, enzymatic study	Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010)	3
RARA	5	TRIP4	2	pull down	Kim HJ (1999)	1
ALKBH3	1	ASCC1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED12	11	MED15	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Mittler G (2003), Hein MY (2015)	3
ASCC2	3	TRIP4	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
MED23	3	MED27	0	bioid	Lambert JP (2015)	1
MED1	4	MED27	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
MED23	3	MED8	0	bioid	Lambert JP (2015)	1
ASCC2	3	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
ASCC1	0	EP300	36	affinity chromatography technology	Yoo HM (2014)	1
MED27	0	MED4	2	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
MED1	4	MED25	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Mittler G (2003), Lee HK (2007), Lee HK (2007), Huttlin EL (2017)	6
RXRA	1	5430	0	imaging technique	Sinkkonen L (2005)	1
MED24	4	MED25	1	biochemical	Wan C (2015)	1
MED1	4	MED11	0	affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Havugimana PC (2012), Huttlin EL (2017)	3
XPO1	8	MED12	11	affinity chromatography technology	Kirli K (2015)	1
MED25	1	CREBBP	29	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Lee HK (2007), Lee HK (2007), Lee HK (2007), Lee HK (2007)	4
MED10	0	5430	0	affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Sato S (2004), Wan C (2015)	3
MED28	2	MED12	11	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Zhang X (2005), Malovannaya A (2010), Malovannaya A (2010)	4
ESR1	0	MED1	4	affinity chromatography technology, pull down, pull down, pull down, pull down, two hybrid, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, two hybrid	Kang YK (2002), Kang YK (2002), Wada-Hiraike O (2005), Burakov D (2000), Burakov D (2000), Burakov D (2000), Burakov D (2000), Llopis J (2000), Llopis J (2000), Fujita T (2003), Fujita T (2003)	11
MED23	3	MED4	2	bioid, affinity chromatography technology, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015), Lambert JP (2015)	3
RELA	1	TRIP4	2	two hybrid, pull down, pull down, two hybrid	Wang J (2011), Jung DJ (2002), Jung DJ (2002), Jung DJ (2002)	4
MED11	0	MED4	2	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
THRB	1	RXRA	1	pull down, pull down, two hybrid, far western blotting, two hybrid, pull down, pull down, pull down, imaging technique	Monden T (1997), Jeyakumar M (1997), Tagami T (2009), Li H (1997), Albers M (2005), White DM (1997), Garcia-Fernandez LF (1998), Liao CS (2009), Liao CS (2009)	9
ESR2	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical	Ogawa S (1998), Ogawa S (1998), Ogawa S (1998), Poelzl G (2000), Rossi V (2009), Monroe DG (2003), Nassa G (2011)	7
ALKBH3	1	TRIP4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MED1	4	MED4	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015), Huttlin EL (2017)	7
ESR1	0	MED24	4	affinity chromatography technology, pull down	Kang YK (2002), Kang YK (2002)	2
NCOA1	6	ESR2	1	two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, two hybrid, two hybrid	Northrop JP (2000), Iannone MA (2001), Fleming FJ (2004), Bai Y (2003), Bramlett KS (2001), Kraichely DM (2000), Kraichely DM (2000), Needham M (2000), Albers M (2005)	9
XPO1	8	NFKB1	2	affinity chromatography technology	Kirli K (2015)	1
ESR2	1	EP300	36	affinity chromatography technology, fluorescent resonance energy transfe	Jin W (2008), Iannone MA (2001)	2
MED11	0	MED27	0	biochemical	Wan C (2015)	1
XBP1	2	TRIP4	2	two hybrid	Ravasi T (2010)	1
MED28	2	RCOR1	0	affinity chromatography technology	Malovannaya A (2010)	1
JUN	0	TRIP4	2	pull down, pull down, two hybrid	Jung DJ (2002), Jung DJ (2002), Jung DJ (2002)	3
NFKB1	2	5430	0	imaging technique	Williams SA (2006)	1
TRIP4	2	MED25	1	affinity chromatography technology	Malovannaya A (2010)	1
CREBBP	29	RARA	5	affinity chromatography technology, affinity chromatography technology	Reineke EL (2007), Tsai LN (2008)	2
MED12	11	MED25	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Mittler G (2003), Hein MY (2015)	3
PPARG	0	JUN	0	unspecified method	Lee G (2002)	1
RELA	1	PPARG	0	affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Hou Y (2012), Hou Y (2012), Lu X (2013), Chen F (2003), Chen F (2003), Perez A (2008), Jeninga EH (2007)	7
MED25	1	MED13	11	affinity chromatography technology	Mittler G (2003)	1
MED4	2	5430	0	bioid	Lambert JP (2015)	1
ESR2	1	MED24	4	pull down	Kang YK (2002)	1
MED12	11	MED13	11	affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Wan C (2015), Hein MY (2015)	3
THRB	1	NCOA1	6	pull down, genetic interference, pull down, unspecified method, two hybrid, two hybrid, pull down, pull down	Liu Y (1998), Jeyakumar M (1997), Jeyakumar M (1997), Jeyakumar M (1997), Albers M (2005), Chan CM (2013), Kim HJ (1999), DiRenzo J (1997)	8
NTRK1	1	5430	0	affinity chromatography technology	Emdal KB (2015)	1
MED27	0	MED17	0	biochemical	Wan C (2015)	1
MED12	11	MED17	0	affinity chromatography technology, biochemical, affinity chromatography technology	Malovannaya A (2010), Wan C (2015), Hein MY (2015)	3
MED12	11	MED8	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	4
CDT1	2	TRIP4	2	affinity chromatography technology	Hein MY (2015)	1
FUS	0	RELA	1	affinity chromatography technology, pull down	Uranishi H (2001), Uranishi H (2001)	2
XPO1	8	ESR1	0	affinity chromatography technology	Castoria G (2012)	1
MED12	11	MED4	2	affinity chromatography technology, biochemical, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015), Hein MY (2015)	6
TRIP4	2	MED13	11	affinity chromatography technology	Malovannaya A (2010)	1
MED28	2	MED15	6	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Malovannaya A (2010)	2
NTRK1	1	FUS	0	affinity chromatography technology	Emdal KB (2015)	1
MED1	4	MED8	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
RELA	1	MED15	6	pull down	Naeaer AM (1999)	1
RXRA	1	TRIP4	2	pull down, two hybrid	Kim HJ (1999), Kim HJ (1999)	2
MED28	2	MED27	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Malovannaya A (2010)	2
SRF	1	NCOA1	6	two hybrid, pull down	Kim HJ (1998), Kim HJ (1998)	2
SRF	1	NFKB1	2	pull down	Schroeter H (1990)	1
MED15	6	MED8	0	biochemical	Wan C (2015)	1
FUS	0	UBC	7	affinity chromatography technology	Wang T (2014)	1
MED4	2	MED17	0	biochemical, bioid, affinity chromatography technology	Wan C (2015), Lambert JP (2015), Lambert JP (2015)	3
MED23	3	EP300	36	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
NTRK1	1	MED23	3	affinity chromatography technology	Emdal KB (2015)	1
ESR2	1	MED12	11	pull down	Kang YK (2002)	1
MED1	4	MED17	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Liu X (2008), Malovannaya A (2010), Donner AJ (2010), Wan C (2015), Huttlin EL (2017)	7
FUS	0	TRIP4	2	affinity chromatography technology	Wang T (2014)	1
MED24	4	MED27	0	biochemical	Wan C (2015)	1
MED4	2	MED25	1	affinity chromatography technology	Lambert JP (2015)	1
RELA	1	MED23	3	pull down	Naeaer AM (1999)	1
ALKBH3	1	ASCC2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RARA	5	NCOA1	6	pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Llopis J (2000), Llopis J (2000), Llopis J (2000), Mouchon A (1999), Torchia J (1997), Reineke EL (2007), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Cai SY (2010), DiRenzo J (1997)	11
JUN	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teyssier C (2001), Baron S (2007), Ruiz ML (2013), Ruiz ML (2013)	4
MED28	2	MED24	4	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Malovannaya A (2010)	2
ESR1	0	MED13	11	pull down	Kang YK (2002)	1
MED10	0	MED4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, bioid, affinity chromatography technology	Sato S (2004), Tomomori-Sato C (2004), Zhang X (2005), Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	7
PPARG	0	NCOA1	6	fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, unspecified method, pull down, two hybrid, pull down, two hybrid, pull down, two hybrid, pull down, unspecified method	Iannone MA (2001), Yang W (2000), Feige JN (2007), DiRenzo J (1997), Needham M (2000), Heinlein CA (1999), Qin C (2004), Chan CM (2013), Chou WL (2007), Nolte RT (1998), Lee G (2002), Agostini M (2006), Waku T (2010), Waku T (2010), Carmona MC (2007), Molnar F (2005), Chintharlapalli S (2007), Jeninga EH (2007), Koppen A (2009)	19
MED1	4	MED12	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Malovannaya A (2010), Donner AJ (2010), Davis MA (2013), Tsai KL (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	10
MED24	4	RXRA	1	pull down	Yuan CX (1998)	1
MED12	11	RCOR1	0	affinity chromatography technology	Malovannaya A (2010)	1
ESR1	0	MED10	0	affinity chromatography technology, pull down	Kang YK (2002), Kang YK (2002)	2
MED10	0	MED27	0	affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Zhang X (2005), Wan C (2015)	3
MED17	0	MED13	11	biochemical	Wan C (2015)	1
EP300	36	CDT1	2	enzymatic study	Glozak MA (2009)	1
SRF	1	RELA	1	pull down	Franzoso G (1996)	1
CREBBP	29	5430	0	biochemical, affinity chromatography technology	Cho H (1998), Cho H (1998)	2
MED25	1	ESR1	0	two hybrid, two hybrid, affinity chromatography technology	Lee HK (2007), Shi Z (2014), Shi Z (2014)	3
MED25	1	MED15	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang F (2004), Mittler G (2003), Mittler G (2003), Mittler G (2003)	4
XPO1	8	CDT1	2	affinity chromatography technology	Kirli K (2015)	1
MED10	0	MED28	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Sato S (2004), Malovannaya A (2010)	3
MED28	2	MED4	2	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sato S (2004), Malovannaya A (2010), Lambert JP (2015), Lambert JP (2015)	4
MED23	3	CREBBP	29	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
TRIP4	2	MED24	4	affinity chromatography technology	Malovannaya A (2010)	1
UBC	7	TRIP4	2	pull down	Zhang X (2017)	1
FUS	0	RXRA	1	pull down	Powers CA (1998)	1
ESR2	1	CREBBP	29	affinity chromatography technology	Jin W (2008)	1
XPO1	8	PPARG	0	affinity chromatography technology	von Knethen A (2010)	1
ESR1	0	CSRP1	0	two hybrid	Arroyo R (2015)	1
RARA	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Subbaramaiah K (2002), Reineke EL (2007)	2
NTRK1	1	TRIP4	2	affinity chromatography technology	Emdal KB (2015)	1
TRIP4	2	MED4	2	affinity chromatography technology	Malovannaya A (2010)	1
MED28	2	MED8	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Malovannaya A (2010)	2
MED15	6	MED17	0	affinity chromatography technology, biochemical	Mittler G (2003), Wan C (2015)	2
MED10	0	MED8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Sato S (2003), Zhang X (2005), Brower CS (2002), Wan C (2015)	8
XPO1	8	TRIP4	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	ASCC1	0	affinity chromatography technology	Kirli K (2015)	1
MED28	2	MED23	3	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Malovannaya A (2010)	2
NCOA1	6	NFKB1	2	pull down, pull down	Lee SK (2000), Na SY (1998)	2
THRB	1	TRIP4	2	pull down, two hybrid	Kim HJ (1999), Kim HJ (1999)	2
NTRK1	1	MED17	0	affinity chromatography technology	Emdal KB (2015)	1
MED23	3	MED13	11	bioid	Lambert JP (2015)	1
ESR2	1	MED1	4	pull down, fluorescent resonance energy transfe, pull down, pull down, two hybrid	Kang YK (2002), Iannone MA (2001), Burakov D (2000), Burakov D (2000), Burakov D (2000)	5
MED4	2	MED13	11	two hybrid, biochemical, bioid, affinity chromatography technology	Nakayama M (2002), Havugimana PC (2012), Lambert JP (2015), Lambert JP (2015)	4
MED23	3	MED24	4	biochemical, bioid, affinity chromatography technology	Wan C (2015), Lambert JP (2015), Lambert JP (2015)	3
TRIP4	2	MED15	6	affinity chromatography technology	Malovannaya A (2010)	1
ESR1	0	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Olivier S (2006), Nettles KW (2008), Nettles KW (2008), Rubio MF (2006), Rubio MF (2006)	5
EP300	36	PPARG	0	pull down, fluorescent resonance energy transfe, affinity chromatography technology, pull down, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, affinity chromatography technology	Fajas L (2002), Iannone MA (2001), Gelman L (1999), Gelman L (1999), Gelman L (1999), Feige JN (2007), Feige JN (2007), Debril MB (2004), Subbaramaiah K (2012), Lee G (2002), Koppen A (2009), Wang C (2001)	12
MED24	4	MED4	2	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
MED4	2	MED8	0	biochemical, biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
MED10	0	MED24	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Zhang X (2005), Malik S (2000)	3
NFKB1	2	TRIP4	2	pull down, pull down, two hybrid	Jung DJ (2002), Jung DJ (2002), Jung DJ (2002)	3
ESR1	0	FUS	0	affinity chromatography technology	Tarallo R (2011)	1
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
MED13	11	MED8	0	biochemical	Wan C (2015)	1
MED15	6	MED23	3	affinity chromatography technology, bioid	Mittler G (2003), Lambert JP (2015)	2
ESR1	0	MED17	0	pull down	Kang YK (2002)	1
MED15	6	MED4	2	biochemical, affinity chromatography technology	Wan C (2015), Lambert JP (2015)	2
NTRK1	1	MED12	11	affinity chromatography technology	Emdal KB (2015)	1
ESR1	0	TRIP4	2	pull down	Kim HJ (1999)	1
MED28	2	MED17	0	affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Sato S (2004), Zhang X (2005), Malovannaya A (2010), Havugimana PC (2012)	4
PPARG	0	TRIP4	2	fluorescent resonance energy transfe, unspecified method	Iannone MA (2001), Koppen A (2009)	2
MED12	11	MED23	3	affinity chromatography technology, bioid, affinity chromatography technology	Malovannaya A (2010), Lambert JP (2015), Hein MY (2015)	3
TRIP4	2	CREBBP	29	pull down, pull down	Kim HJ (1999), Kim HJ (1999)	2
ESR1	0	5430	0	affinity chromatography technology, imaging technique, imaging technique, pull down	Ambrosino C (2010), Zhang H (2006), Zhang H (2006), Nalvarte I (2010)	4
ASCC1	0	NCOA1	6	affinity chromatography technology	Yoo HM (2014)	1
MED1	4	MED13	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang X (2005), Zhang X (2005), Malovannaya A (2010), Donner AJ (2010), Davis MA (2013), Tsai KL (2013), Wan C (2015), Huttlin EL (2017)	8
MED28	2	MED11	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Malovannaya A (2010)	2
NFKB1	2	RXRA	1	pull down	Na SY (1999)	1
RARA	5	SRF	1	two hybrid, pull down	Kim SW (2001), Kim SW (2001)	2
TRIP4	2	MED23	3	affinity chromatography technology	Malovannaya A (2010)	1
MED23	3	RCOR1	0	affinity chromatography technology	Lambert JP (2015)	1
ESR2	1	MED10	0	pull down	Kang YK (2002)	1
ESR2	1	MED4	2	affinity chromatography technology	Nassa G (2011)	1
TRIP4	2	MED28	2	affinity chromatography technology	Malovannaya A (2010)	1
NFKB1	2	PPARG	0	affinity chromatography technology, pull down	Perez A (2008), Perez A (2008)	2
ASCC1	0	ASCC2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
PPARG	0	UBC	7	enzymatic study	Hou Y (2012)	1
RXRA	1	MED1	4	imaging technique, pull down, two hybrid, two hybrid	Sinkkonen L (2005), Yang W (2000), Shao G (2000), Osburn DL (2001)	4
MED10	0	MED23	3	affinity chromatography technology, affinity chromatography technology, biochemical, bioid	Sato S (2004), Zhang X (2005), Wan C (2015), Lambert JP (2015)	4
TRIP4	2	5430	0	affinity chromatography technology	Malovannaya A (2010)	1
MED24	4	PPARG	0	pull down	Yuan CX (1998)	1
ASCC1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology	Yoo HM (2014), Yoo HM (2014)	2
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
MED13	11	MED24	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MED10	0	MED17	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Tomomori-Sato C (2004), Sato S (2003), Sato S (2003), Zhang X (2005), Zhang X (2005), Malik S (2000), Brower CS (2002), Wan C (2015)	9
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
KIF11	5	TRIP4	2	affinity chromatography technology	Hein MY (2015)	1
NCOA1	6	EP300	36	affinity chromatography technology, imaging technique, pull down, pull down	Matsuda S (2004), Wang F (2010), Kino T (2002), Nasrin N (2000)	4
MED12	11	MED27	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Malovannaya A (2010), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	4
MED10	0	MED15	6	affinity chromatography technology, affinity chromatography technology, biochemical	Sato S (2004), Zhang X (2005), Wan C (2015)	3
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
MED25	1	MED23	3	affinity chromatography technology, biochemical, bioid, affinity chromatography technology	Mittler G (2003), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
ESR1	0	MED27	0	pull down	Nalvarte I (2010)	1
RXRA	1	RARA	5	pull down, biochemical, affinity chromatography technology, x-ray crystallography, far western blotting, two hybrid, imaging technique, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Benkoussa M (2002), Bugge TH (1992), Wu Q (2004), Pogenberg V (2005), Li H (1997), Albers M (2005), Bellodi C (2006), Garcia-Fernandez LF (1998), Wang J (2011), Rochel N (2011), Rochel N (2011), Perlmann T (1995), Perlmann T (1995), DiRenzo J (1997), Martin PJ (2003), Martin PJ (2003), Chen TC (2014), Fujiu K (2005), Fujiu K (2005)	19
RXRA	1	SRF	1	two hybrid	Kim SW (2001)	1
TRIP4	2	MED12	11	affinity chromatography technology	Malovannaya A (2010)	1
MED15	6	MED11	0	biochemical	Wan C (2015)	1
JUN	0	UBC	7	two hybrid, protein complementation assay	Bandyopadhyay S (2010), Fang D (2004)	2
MED28	2	MED1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Zhang X (2005), Malovannaya A (2010), Malovannaya A (2010), Huttlin EL (2017)	5
NCOA1	6	JUN	0	pull down, pull down, two hybrid, pull down	Lee SK (1999), Lee SK (2000), Lee SK (1998), Lee SK (1998)	4