PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NIN	4	HMGN3	0	bioid	Gupta GD (2015)	1
TERF1	1	HMGN3	0	two hybrid	Lee OH (2011)	1
TERF2	2	TERF2IP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	OConnor MS (2004), OConnor MS (2004), OConnor MS (2004), Li B (2000), Zhu XD (2000), Zhu XD (2000), Chen Y (2011), Chen Y (2011), Chen Y (2011), Chen Y (2011), Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Her YR (2009), Havugimana PC (2012), Her YR (2013), Wan C (2015), Hein MY (2015), Her J (2015), Arat N Oe (2012), Li JS (2017), Jeong YY (2016), Ilic A (2017), Ilic A (2017)	28
SRPK2	1	HMGN3	0	enzymatic study	Varjosalo M (2013)	1
SRPK1	2	HMGN3	0	enzymatic study	Varjosalo M (2013)	1
VDR	2	HMGN3	0	two hybrid	Albers M (2005)	1
TERF1	1	TERF2IP	1	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015)	6
TERF2IP	1	HMGN3	0	two hybrid	Lee OH (2011)	1
SRPK1	2	VDR	2	enzymatic study	Varjosalo M (2013)	1
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
THRB	1	HMGN3	0	two hybrid	Albers M (2005)	1
TERF2	2	HMGN3	0	two hybrid	Lee OH (2011)	1