PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	LRP8	4	affinity chromatography technology	Choudhury NR (2017)	1
ITGB1BP1	0	FIGNL1	2	two hybrid	Rolland T (2014)	1
ITGB1BP1	0	TANK	1	affinity chromatography technology	Rothe M (1996)	1
TANK	1	APP	1	pull down	Olah J (2011)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
SMURF1	4	XPO1	8	affinity chromatography technology	Tajima Y (2003)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
LRP8	4	ITGB1BP1	0	two hybrid	Gotthardt M (2000)	1
ITGB1BP1	0	APP	1	pull down	Olah J (2011)	1
ITGB1BP1	0	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
TRIM25	5	ITGB1BP1	0	affinity chromatography technology	Choudhury NR (2017)	1
ITGB1BP1	0	SMURF1	4	affinity chromatography technology, pull down	Bouin AP (2017), Bouin AP (2017)	2
LRP1	25	APP	1	affinity chromatography technology	Lakshmana MK (2009)	1
APP	1	LRP2	13	pull down	Hammad SM (1997)	1
CCM2	2	SMURF1	4	affinity chromatography technology, pull down, affinity chromatography technology	Crose LE (2009), Crose LE (2009), Crose LE (2009)	3
ITGB1BP1	0	FAF1	1	two hybrid	Vinayagam A (2011)	1
LRP1	25	ITGB1BP1	0	two hybrid, pull down	Gotthardt M (2000), Gotthardt M (2000)	2
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	ITGB1BP1	0	affinity chromatography technology	Kirli K (2015)	1
CCM2	2	ITGB1BP1	0	affinity chromatography technology	Huttlin EL (2017)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
SMURF2	3	ITGB1BP1	0	pull down	Bouin AP (2017)	1
LRP2	13	ITGB1BP1	0	two hybrid, pull down	Gotthardt M (2000), Gotthardt M (2000)	2
SMURF1	4	EEF1A1	0	affinity chromatography technology	Xie Y (2013)	1
SMURF2	3	XPO1	8	affinity chromatography technology, affinity chromatography technology, pull down	Kim DG (2016), Kim DG (2016), Kim DG (2016)	3
CCM2	2	KRIT1	1	two hybrid, affinity chromatography technology	Grossmann A (2015), Huttlin EL (2017)	2
ITGB1	4	ITGB1BP1	0	pull down, affinity chromatography technology, pull down, pull down, pull down	Chang DD (1997), Chang DD (1997), Chang DD (2002), Bouin AP (2017), Bouin AP (2017)	5
ITGB1BP1	0	PGRMC1	1	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
TRIM25	5	FAF1	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PGRMC1	1	affinity chromatography technology	Choudhury NR (2017)	1
KRIT1	1	ITGB1BP1	0	two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology	Zhang J (2001), Zhang J (2001), Zhang J (2001), Zawistowski JS (2002), Zawistowski JS (2002), Zawistowski JS (2002), Grossmann A (2015), Huttlin EL (2017)	8
TRIM25	5	CCM2	2	affinity chromatography technology	Choudhury NR (2017)	1
SMURF2	3	CCM2	2	affinity chromatography technology	Crose LE (2009)	1
TRIM25	5	EEF1A1	0	biochemical	Wan C (2015)	1