PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CYTH2	2	PNPLA2	2	two hybrid, affinity chromatography technology	Ellong EN (2011), Ellong EN (2011)	2
CYTH2	2	CCDC120	1	two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2017)	3
ARL4D	0	ARF6	0	imaging technique	Li CC (2007)	1
TRIM23	3	CYTH2	2	pull down	Vitale N (2000)	1
ARF1	1	GGA3	6	two hybrid, two hybrid, two hybrid, pull down, pull down	DellAngelica EC (2000), Puertollano R (2001), Puertollano R (2001), DellAngelica EC (2000), Takatsu H (2002)	5
ARF6	0	GNAQ	1	affinity chromatography technology	Giguere P (2006)	1
CCDC40	6	CYTH2	2	affinity chromatography technology	Huttlin EL (2017)	1
MAPK6	1	CYTH2	2	two hybrid	Vinayagam A (2011)	1
SFN	1	CYTH2	2	affinity chromatography technology	Benzinger A (2005)	1
GGA3	6	ARF6	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Cho HJ (2010), Frittoli E (2008), Jing J (2009), Li CC (2007)	4
CYTH2	2	ARF6	0	enzymatic study, affinity chromatography technology, pull down	Frank S (1998), Yano H (2008), Laroche G (2007)	3
FOSL2	2	CYTH2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ADORA2A	0	CYTH2	2	two hybrid, pull down, affinity chromatography technology	Gsandtner I (2005), Gsandtner I (2005), Gsandtner I (2005)	3
CYTH2	2	ARL4D	0	affinity chromatography technology, two hybrid, pull down, imaging technique	Li CC (2007), Li CC (2007), Li CC (2007), Li CC (2007)	4
MTMR7	0	CYTH2	2	affinity chromatography technology	Li X (2016)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
CYTH2	2	ARRB1	2	affinity chromatography technology, pull down	Claing A (2001), Claing A (2001)	2
CYTIP	3	CYTH2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
C1orf106	0	CYTH2	2	affinity chromatography technology	Huttlin EL (2017)	1
ARRB1	2	ARF6	0	affinity chromatography technology, pull down	Claing A (2001), Claing A (2001)	2
GNAQ	1	PIK3CA	8	affinity chromatography technology	Ballou LM (2003)	1
APC	5	CYTH2	2	two hybrid	Bandyopadhyay S (2010)	1
CYTH2	2	ARRB2	5	affinity chromatography technology, pull down	Claing A (2001), Claing A (2001)	2
PIK3CA	8	CYTH2	2	protein complementation assay	Miao B (2010)	1
CYTH2	2	GNAQ	1	affinity chromatography technology, pull down	Giguere P (2006), Giguere P (2006)	2
SFN	1	APC	5	affinity chromatography technology	Benzinger A (2005)	1
CYTH2	2	ARF1	1	enzymatic study	Frank S (1998)	1
GGA3	6	CYTH2	2	pull down	Li CC (2007)	1
IPCEF1	2	CYTH2	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Venkateswarlu K (2003), Venkateswarlu K (2003), Venkateswarlu K (2003), Venkateswarlu K (2003), Huttlin EL (2017)	5
ARRB2	5	ARF6	0	affinity chromatography technology	Claing A (2001)	1
CNKSR1	2	CYTH2	2	affinity chromatography technology	Huttlin EL (2017)	1
CYTH2	2	ARL4A	0	two hybrid	Li CC (2007)	1