PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UNC5CL	5	NUMBL	1	affinity chromatography technology	Huttlin EL (2017)	1
NUMBL	1	THPO	0	two hybrid	Wang J (2011)	1
TRAF5	1	NUMBL	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Tao T (2012), Tao T (2012), Wang J (2011)	3
XPO1	8	NUMBL	1	affinity chromatography technology	Kirli K (2015)	1
HNRNPL	3	CTDSPL	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	NUMBL	1	affinity chromatography technology	Fei T (2017)	1
MAGED1	0	NUMBL	1	two hybrid	Wang J (2011)	1
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
TRAF6	0	NUMBL	1	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhou L (2010), Zhou L (2010), Tao T (2012), Wang J (2011), Swarnkar G (2017)	5
NUMBL	1	SIAH1	2	two hybrid	Wang J (2011)	1
ACTN1	5	NUMBL	1	two hybrid	Wang J (2011)	1
GTSE1	3	NUMBL	1	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	LIMA1	4	bioid	Guo Z (2014)	1
RAB3IP	0	LIMA1	4	affinity chromatography technology	Boldt K (2016)	1
IKBKG	0	PSMA3	1	pull down	Fenner BJ (2010)	1
KBTBD7	3	GTSE1	3	affinity chromatography technology	Huttlin EL (2017)	1
LNX1	7	NUMBL	1	affinity chromatography technology	Lenihan JA (2017)	1
RBFOX1	1	NUMBL	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
GAA	3	NUMBL	1	two hybrid	Wang J (2011)	1
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
EGFR	5	NUMBL	1	unspecified method	Jones RB (2006)	1
HNRNPL	3	RAB3IP	0	affinity chromatography technology	Fei T (2017)	1
RBFOX1	1	ATXN1	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
RIPK1	2	TRAF5	1	affinity chromatography technology	Tada K (2001)	1
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
GPATCH8	5	NUMBL	1	two hybrid	Wang J (2011)	1
GRIP1	1	NUMBL	1	two hybrid	Ye B (2000)	1
RBFOX1	1	MAGED1	0	two hybrid, two hybrid	Lim J (2006), Corominas R (2014)	2
IKBKG	0	NUMBL	1	affinity chromatography technology	Swarnkar G (2017)	1
CTDSPL	1	NUMBL	1	bioid	St-Denis N (2016)	1
XPO1	8	RIPK1	2	affinity chromatography technology	Kirli K (2015)	1
NUMBL	1	PSMA3	1	two hybrid	Wang J (2011)	1
RAB3IP	0	NUMBL	1	affinity chromatography technology	Boldt K (2016)	1
BHLHE40	5	MAGED1	0	two hybrid	Rolland T (2014)	1
KIAA1107	3	NUMBL	1	affinity chromatography technology	Hein MY (2015)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
GTSE1	3	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	GTSE1	3	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	PSMA3	1	affinity chromatography technology	Yao Z (2017)	1
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
ESRP2	2	NUMBL	1	two hybrid	Wang J (2011)	1
BHLHE40	5	NUMBL	1	two hybrid	Wang J (2011)	1
TRAF6	0	TRAF5	1	two hybrid, two hybrid, two hybrid, pull down	Woodsmith J (2012), Rolland T (2014), Yu H (2011), Middleton AJ (2017)	4
CTDSPL	1	EGFR	5	bioid	St-Denis N (2016)	1
HNRNPL	3	ATXN1	2	affinity chromatography technology	Fei T (2017)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
KBTBD7	3	NUMBL	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	KBTBD7	3	affinity chromatography technology	Yao Z (2017)	1
NUMBL	1	RIPK1	2	two hybrid	Wang J (2011)	1
RBFOX1	1	BHLHE40	5	two hybrid	Corominas R (2014)	1
NUMBL	1	SPSB3	1	two hybrid	Rolland T (2014)	1
XPO1	8	TAB2	5	affinity chromatography technology	Kirli K (2015)	1
CDH1	4	ACTN1	5	affinity chromatography technology	Hazan RB (1998)	1
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
EGFR	5	GPATCH8	5	affinity chromatography technology	Yao Z (2017)	1
ATXN1	2	GPATCH8	5	two hybrid	Lim J (2006)	1
RIPK1	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma Q (2008), Ea CK (2006), Kanayama A (2004), Kanayama A (2004)	4
LIMA1	4	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
CDH1	4	NUMBL	1	bioid	Guo Z (2014)	1
SLC1A1	1	NUMBL	1	affinity chromatography technology	Huttlin EL (2017)	1
NUMBL	1	TAB2	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Ma Q (2008), Ma Q (2008), Ma Q (2008), Ma Q (2008), Wang J (2011)	5
ATXN1	2	NUMBL	1	two hybrid	Lim J (2006)	1
EGFR	5	CBY1	3	affinity chromatography technology	Yao Z (2017)	1
LIMA1	4	NUMBL	1	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	SLC1A1	1	affinity chromatography technology	Fei T (2017)	1
RAB3IP	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
NUMBL	1	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
NUMBL	1	TMC5	2	two hybrid	Wang J (2011)	1
EGFR	5	LIMA1	4	affinity chromatography technology	Tong J (2014)	1