PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RPGRIP1	6	DLG5	5	bioid	Gupta GD (2015)	1
GAN	4	DLG5	5	affinity chromatography technology	Johnson-Kerner BL (2015)	1
TERF1	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Wang C (2013), Wang C (2013)	2
CEP135	2	DLG5	5	bioid	Gupta GD (2015)	1
GAN	4	NINL	1	affinity chromatography technology	Johnson-Kerner BL (2015)	1
CEP135	2	CEP152	2	bioid	Gupta GD (2015)	1
CEP89	2	MED4	2	bioid	Gupta GD (2015)	1
CDH1	4	PFN1	0	bioid	Guo Z (2014)	1
CEP89	2	MARK2	6	bioid	Gupta GD (2015)	1
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
BTBD10	4	DLG5	5	two hybrid	Stelzl U (2005)	1
SORBS3	5	DLG5	5	two hybrid, pull down, affinity chromatography technology	Wakabayashi M (2003), Wakabayashi M (2003), Wakabayashi M (2003)	3
TERF1	1	DLG5	5	two hybrid	Stelzl U (2005)	1
UBC	7	DLST	3	affinity chromatography technology	Matsumoto M (2005)	1
CEP89	2	DLG5	5	bioid	Gupta GD (2015)	1
CEP152	2	FGFR1OP	0	bioid	Gupta GD (2015)	1
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
MED4	2	CEP152	2	bioid	Lambert JP (2015)	1
CEP128	1	CTNNB1	30	bioid	Gupta GD (2015)	1
CD81	0	DLG5	5	two hybrid	Stelzl U (2005)	1
SASS6	1	CEP152	2	bioid	Gupta GD (2015)	1
PFN1	0	DLG5	5	two hybrid	Stelzl U (2005)	1
GAN	4	CUL3	17	affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Bennett EJ (2010)	2
CEP152	2	DLG5	5	bioid	Gupta GD (2015)	1
MED4	2	FGFR1OP	0	bioid	Lambert JP (2015)	1
SASS6	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
MED4	2	DLG5	5	bioid	Lambert JP (2015)	1
FGFR1OP	0	DLG5	5	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	DLG5	5	affinity chromatography technology	Bennett EJ (2010)	1
CEP89	2	FGFR1OP	0	bioid	Gupta GD (2015)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
CDK1	0	DLG5	5	affinity chromatography technology	Hein MY (2015)	1
MED4	2	CEP135	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
CNTRL	5	DLG5	5	bioid	Gupta GD (2015)	1
CUL3	17	BAG5	0	affinity chromatography technology	Bennett EJ (2010)	1
CEP152	2	CEP128	1	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
CUL3	17	CTNNB1	30	affinity chromatography technology	Bennett EJ (2010)	1
CEP128	1	CEP89	2	bioid	Gupta GD (2015)	1
CEP128	1	MED4	2	bioid	Gupta GD (2015)	1
CEP135	2	FGFR1OP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
ODF2	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
MARK2	6	MARK3	2	affinity chromatography technology	Sowa ME (2009)	1
DLST	3	TPM1	0	affinity chromatography technology	Malty RH (2017)	1
NINL	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
BTRC	1	DLG5	5	bioid	Coyaud E (2015)	1
SASS6	1	DLG5	5	bioid	Gupta GD (2015)	1
CNTRL	5	CEP152	2	bioid	Gupta GD (2015)	1
BAG5	0	DLG5	5	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CUL3	17	PFN1	0	affinity chromatography technology	Bennett EJ (2010)	1
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
DLST	3	CDK1	0	affinity chromatography technology	Malty RH (2017)	1
CEP104	4	DLG5	5	bioid	Gupta GD (2015)	1
DLST	3	DLG5	5	two hybrid	Stelzl U (2005)	1
ODF2	1	DLG5	5	bioid	Gupta GD (2015)	1
BTRC	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Herrero-Ruiz J (2014), Herrero-Ruiz J (2014), Herrero-Ruiz J (2014), Herrero-Ruiz J (2014)	4
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CUL3	17	BTBD10	4	affinity chromatography technology, two hybrid, affinity chromatography technology	Bennett EJ (2010), Wang J (2011), Huttlin EL (2017)	3
NINL	1	CEP89	2	bioid	Gupta GD (2015)	1
CDH1	4	MARK2	6	bioid	Guo Z (2014)	1
CNTRL	5	ODF2	1	bioid	Gupta GD (2015)	1
CEP128	1	DLG5	5	bioid	Gupta GD (2015)	1
MARK3	2	DLG5	5	affinity chromatography technology	So J (2015)	1
CDH1	4	UBC	7	bioid	Guo Z (2014)	1
NINL	1	SASS6	1	bioid	Gupta GD (2015)	1
DLG5	5	CTNNB1	30	affinity chromatography technology	Wakabayashi M (2003)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CDH1	4	DLG5	5	bioid	Guo Z (2014)	1
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
CEP128	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
UBC	7	DLG5	5	affinity chromatography technology	Matsumoto M (2005)	1
DLST	3	PFN1	0	affinity chromatography technology	Malty RH (2017)	1
CNTRL	5	MED4	2	bioid	Gupta GD (2015)	1
TPM1	0	DLG5	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CNTRL	5	CEP89	2	bioid	Gupta GD (2015)	1
SASS6	1	MED4	2	bioid	Gupta GD (2015)	1
NINL	1	DLG5	5	bioid	Gupta GD (2015)	1
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MARK2	6	DLG5	5	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	MARK3	2	bioid	Guo Z (2014)	1
MED4	2	ODF2	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2