PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SHANK1	7	SHANK3	18	affinity chromatography technology	Mameza MG (2013)	1
APC	5	CTNNB1	30	affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su LK (1993), Su LK (1993), Kucerova D (2001), Tickenbrock L (2003), Davies G (2001), Ryo A (2001), Homma MK (2002), Tickenbrock L (2003), Davies G (2001), Satoh K (1997), Eklof Spink K (2001), Eklof Spink K (2001), Sierra J (2006), Choi J (2004), Huang X (2009), Brocardo MG (2011), Xing Y (2004), Xing Y (2004), Xing Y (2004), Hamada F (2004), Hamada F (2004), Schneikert J (2013), Hsi LC (1999), Hein MY (2015), Hein MY (2015), Chen TC (2014), Kuslansky Y (2016), Novellasdemunt L (2017), Novellasdemunt L (2017)	29
DYNLL1	0	MYO5A	17	pull down, pull down, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Lo KW (2001)	4
ITSN2	7	DLGAP1	6	two hybrid	Wong KA (2012)	1
GRIN2A	13	DLG3	1	two hybrid, affinity chromatography technology, pull down	Irie M (1997), Lim IA (2002), Lim IA (2002)	3
DLG3	1	DLGAP1	6	two hybrid	Takeuchi M (1997)	1
DYNLL1	0	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
DLGAP1	6	DYNLL2	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000)	6
ITSN1	5	ITSN2	7	protein complementation assay	Wong KA (2012)	1
ITSN1	5	DLGAP1	6	two hybrid	Wong KA (2012)	1
DLG1	2	DLGAP1	6	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, far western blotting	Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Satoh K (1997), Wu H (2000), Wu H (2000), Kim E (1997), Kim E (1997)	8
GRIN2A	13	DLG2	4	two hybrid	Irie M (1997)	1
SHANK2	8	DYNLL1	0	affinity chromatography technology	Naisbitt S (2000)	1
SHANK3	18	DLGAP1	6	two hybrid	Boeckers TM (1999)	1
GRIN2A	13	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology	Hou XY (2002), Hou XY (2002), Irie M (1997), Irie M (1997), Satoh K (1997), Sans N (2000), Lim IA (2002), Lim IA (2002), Niethammer M (1996), Niethammer M (1996), Papadakis M (2004)	11
DLG3	1	APC	5	pull down, two hybrid	Makino K (1997), Makino K (1997)	2
SHANK2	8	DYNLL2	0	affinity chromatography technology	Naisbitt S (2000)	1
DYNLL2	0	DLG4	11	pull down, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000)	2
DYNLL2	0	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
DLGAP1	6	MYO5A	17	pull down	Naisbitt S (2000)	1
GRB2	2	DLGAP1	6	two hybrid	Bandyopadhyay S (2010)	1
DLGAP1	6	DLG4	11	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Takeuchi M (1997), Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Boeckers TM (1999), Wu H (2000), Kim E (1997), Kim E (1997), Kim E (1997), Kim E (1997)	11
SORBS2	2	DLGAP1	6	pull down	Kawabe H (1999)	1
DLG3	1	DLG4	11	two hybrid, pull down	Masuko N (1999), Masuko N (1999)	2
DLGAP1	6	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
DLGAP1	6	DYNLL1	0	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Lo KW (2001)	6
DLGAP1	6	CTNNB1	30	affinity chromatography technology	Satoh K (1997)	1
SHANK1	7	DLGAP1	6	x-ray crystallography	Im YJ (2003)	1
SHANK2	8	DLG4	11	affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Boeckers TM (1999)	2
DLGAP1	6	GRIN2A	13	affinity chromatography technology	Satoh K (1997)	1
DLG3	1	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
APC	5	DLGAP1	6	affinity chromatography technology	Satoh K (1997)	1
GRB2	2	SHANK3	18	two hybrid	Wang J (2011)	1
DYNLL1	0	DYNLL2	0	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
DLGAP1	6	SHANK2	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Boeckers TM (1999), Boeckers TM (1999), Boeckers TM (1999)	5
SHANK2	8	MYO5A	17	affinity chromatography technology	Naisbitt S (2000)	1
DYNLL1	0	DLG4	11	pull down, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000)	2
DYNLL2	0	MYO5A	17	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Puthalakath H (2001)	5
GRIN2A	13	DLG1	2	affinity chromatography technology, pull down, two hybrid	Gardoni F (2003), Gardoni F (2003), Niethammer M (1996)	3