PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DLGAP2	4	TSPOAP1	9	two hybrid	Corominas R (2014)	1
DLGAP2	4	KRTAP4-2	0	two hybrid	Rolland T (2014)	1
SHANK2	8	DLGAP2	4	two hybrid	Boeckers TM (1999)	1
SHANK2	8	DLG4	11	affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Boeckers TM (1999)	2
DGCR6	0	DLGAP2	4	two hybrid	Corominas R (2014)	1
SHANK3	18	DLGAP2	4	two hybrid	Boeckers TM (1999)	1
DLGAP2	4	KRT40	0	two hybrid	Rolland T (2014)	1
DLG4	11	DLGAP2	4	two hybrid, pull down	Takeuchi M (1997), Takeuchi M (1997)	2