Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HTR3B 9177 GRANISETRON CHEMBL289469 TdgClinicalTrial
HTR3B 9177 CHEMBL28992 CHEMBL28992 antagonist GuideToPharmacologyInteractions
HTR3B 9177 TUBOCURARINE CHEMBL339427 antagonist GuideToPharmacologyInteractions
HTR3B 9177 BILOBALIDE CHEMBL133266 channel blocker GuideToPharmacologyInteractions
HTR3B 9177 CHEMBL1188853 CHEMBL1188853 TdgClinicalTrial
HTR3B 9177 DOLASETRON CHEMBL2368925 TdgClinicalTrial
HTR3B 9177 PHENYL BIGUANIDE CHEMBL13791 agonist GuideToPharmacologyInteractions
HTR3B 9177 CHEMBL266591 CHEMBL266591 agonist GuideToPharmacologyInteractions
HTR3B 9177 QUIPAZINE CHEMBL18772 agonist GuideToPharmacologyInteractions
HTR3B 9177 AZASETRON CHEMBL1598608 antagonist GuideToPharmacologyInteractions
HTR3B 9177 ONDANSETRON CHEMBL46 antagonist GuideToPharmacologyInteractions
HTR3B 9177 RG3487 CHEMBL3544952 antagonist ChemblInteractions
HTR3B 9177 TEDATIOXETINE CHEMBL2104986 antagonist ChemblInteractions
HTR3B 9177 SEROTONIN CHEMBL39 agonist GuideToPharmacologyInteractions
HTR3B 9177 PUMOSETRAG CHEMBL1643880 TdgClinicalTrial
HTR3B 9177 CILANSETRON CHEMBL2103778 antagonist ChemblInteractions, TTD
HTR3B 9177 COCAINE CHEMBL370805 antagonist GuideToPharmacologyInteractions
HTR3B 9177 (R)ZACOPRIDE CHEMBL27846 antagonist GuideToPharmacologyInteractions
HTR3B 9177 METOCLOPRAMIDE CHEMBL86 antagonist GuideToPharmacologyInteractions
HTR3B 9177 PICROTOXININ CHEMBL47244 channel blocker GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HTR3B rs45460698 del/del granisetron efficacy no Patients with cancer, treated with cisplatin who had been treated with granisetron and palonsetron. Nausea and vomiting episodes were recorded for the first 120 h post cisplatin. With regard to vomiting events, presence/absence of symptoms and the time of onset were described. Nausea severity was categorized using a 4-point Likert scale (0 = no nausea, 1 = mild nausea, 2 = moderate nausea and 3 = severe nausea) according to the subjective assessment of each patient. Genotype del/del is not associated with response to granisetron or palonosetron in people with Nausea and Vomiting as compared to genotypes AAG/AAG + AAG/del. 29177570 1449170266
HTR3B rs1176744 AA granisetron efficacy no Genotype AA is not associated with response to granisetron in healthy individuals as compared to genotypes AC + CC. 28002447 1448995581
HTR3B rs11214763 A opioids dosage no Variant was significantly associated with opioid dose in the development sample, but lost significance in the validation sample. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714104
HTR3B rs11606194 C opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele C is not associated with dose of opioids in people with Pain as compared to allele T. 21398039 1449714862
HTR3B rs7103572 C opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele C is not associated with dose of opioids in people with Pain as compared to allele T. 21398039 1449714869
HTR3B rs1176744 C opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Please note that alleles have been complemented to the positive strand. Allele C is not associated with dose of opioids in people with Pain as compared to allele A. 21398039 1449714876
HTR3B rs2276307 A opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714883
HTR3B rs7943062 A opioids dosage no Variant was significantly associated with opioid dose in the development sample, but lost significance in the validation sample. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714116
HTR3B rs3782025 A opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Please note that alleles have been complemented to the positive strand. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714892
HTR3B rs1672717 A opioids dosage no Variant had no significant association with opioid dose in either the development sample or the validation sample. Please note that alleles have been complemented to the positive strand. Allele A is not associated with dose of opioids in people with Pain as compared to allele G. 21398039 1449714901