PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LCK	0	SYK	3	affinity chromatography technology, pull down, two hybrid	Thome M (1995), Thome M (1995), Moon KD (2005)	3
CD3E	0	LCK	0	affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003)	2
PTPN22	3	CD247	1	affinity chromatography technology	Wu J (2006)	1
CD3E	0	FAM241B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CD3E	0	CD3G	0	affinity chromatography technology	Borroto A (1998)	1
LCK	0	PIK3R1	6	pull down	Kapeller R (1994)	1
CSK	3	CD3E	0	pull down	Catipovic B (1996)	1
CD3E	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	de Aos I (1997), Alcazar I (2009)	2
LAT	0	PIK3R1	6	affinity chromatography technology, pull down	Paz PE (2001), Paz PE (2001)	2
PTPN22	3	LCK	0	affinity chromatography technology, affinity chromatography technology	Wu J (2006), Wu J (2006)	2
CD3E	0	CD3EAP	3	affinity chromatography technology, pull down	Yamazaki T (1999), Yamazaki T (1999)	2
LCK	0	LAT	0	biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Jiang Y (2007), Jiang Y (2007)	4
SYK	3	PIK3R1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Moon KD (2005), Moon KD (2005), Moon KD (2005), Moon KD (2005), Huang ZY (2006)	5
CD38	0	CD247	1	affinity chromatography technology, biochemical	Munoz P (2003), Munoz P (2003)	2
PTPN22	3	CSK	3	bioid, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
NCK1	0	PIK3R1	6	affinity chromatography technology	Gelkop S (2001)	1
CD3E	0	JAK3	3	affinity chromatography technology	Tomita K (2001)	1
CD3E	0	GHDC	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCL	1	CD3EAP	3	pull down	Kobayashi J (2012)	1
NCK2	2	NCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCK2	2	CD3E	0	pull down, pull down, two hybrid	Gil D (2002), Gil D (2002), Gil D (2002)	3
LCK	0	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pelosi M (1999), Thome M (1995), Lupher ML (1996)	3
NCL	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Huddleson JP (2006), Huddleson JP (2006)	2
CD247	1	JAK3	3	affinity chromatography technology, pull down	Tomita K (2001), Tomita K (2001)	2
SNTA1	1	CD3E	0	unspecified method	Boisguerin P (2004)	1
CD247	1	LCK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Yang M (2015)	3
CD3E	0	HLA-A	0	affinity chromatography technology	Huttlin EL (2015)	1
NCK1	0	CD3E	0	pull down	Gil D (2002)	1
SYK	3	PIK3R2	3	two hybrid	Moon KD (2005)	1
SYK	3	NCK1	0	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
ZAP70	5	LAT	0	enzymatic study, enzymatic study, imaging technique, affinity chromatography technology	Paz PE (2001), Perez-Villar JJ (2002), Houtman JC (2006), Xie JJ (2013)	4
CSK	3	ZAP70	5	pull down	Catipovic B (1996)	1
CD38	0	ZAP70	5	biochemical	Munoz P (2003)	1
PTPN22	3	ZAP70	5	affinity chromatography technology, affinity chromatography technology	Wu J (2006), Wu J (2006)	2
CD247	1	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mustelin T (1995), Wang HY (2001), La Face DM (1997), Huang H (2010), Huang H (2010), Hubert P (1996), Yang M (2015)	7
SYK	3	CD3E	0	pull down	Bu JY (1995)	1
ZAP70	5	CD3E	0	pull down, affinity chromatography technology	Bu JY (1995), Hubert P (1996)	2
PIK3R1	6	CD247	1	affinity chromatography technology	Fang D (2001)	1
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
CD3E	0	GP1BB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTPN22	3	CD3E	0	affinity chromatography technology, affinity chromatography technology	Wu J (2006), Wu J (2006)	2
CD3E	0	CD247	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Munoz P (2003), Munoz P (2003), Chen TC (2014)	3
CD38	0	LCK	0	affinity chromatography technology	Munoz P (2003)	1
CD38	0	CD3E	0	affinity chromatography technology, biochemical	Munoz P (2003), Munoz P (2003)	2
CD3E	0	TM2D3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LAT	0	CD247	1	affinity chromatography technology	Munoz P (2003)	1
SYK	3	LAT	0	enzymatic study	Paz PE (2001)	1
CD3E	0	PIK3R2	3	affinity chromatography technology	Alcazar I (2009)	1
CD3E	0	LNPEP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSK	3	CD247	1	pull down, affinity chromatography technology	Catipovic B (1996), Catipovic B (1996)	2
CD3E	0	ITPRIPL1	4	affinity chromatography technology	Huttlin EL (2015)	1
CD3E	0	NCL	1	pull down	Gil D (2001)	1
LAT	0	CD3E	0	affinity chromatography technology	Munoz P (2003)	1
PIK3R1	6	ZAP70	5	affinity chromatography technology	Moon KD (2005)	1
CD3E	0	TOP2B	9	affinity chromatography technology, pull down	Nakano H (1996), Nakano H (1996)	2