PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
MSH2	4	ATM	9	biochemical	Wang Y (2000)	1
YWHAE	0	KPNB1	3	affinity chromatography technology	Zuo S (2010)	1
EXO1	3	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, pull down	Engels K (2011), Engels K (2011), Andersen SD (2012), Andersen SD (2012)	4
MYEF2	2	EXO1	3	affinity chromatography technology	Hein MY (2015)	1
KLC3	3	EXO1	3	affinity chromatography technology	Hein MY (2015)	1
LLGL2	4	EXO1	3	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	MSH2	4	affinity chromatography technology	Choudhury NR (2017)	1
BLM	2	UBE2I	0	two hybrid, affinity chromatography technology	Eladad S (2005), Eladad S (2005)	2
EXO1	3	MLH1	6	pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, pull down	Schmutte C (2001), Schmutte C (2001), Dherin C (2009), Dherin C (2009), Cannavo E (2007), Engels K (2011), Engels K (2011), Nielsen FC (2004), Andersen SD (2012), Jaeger AC (2001)	10
MSH2	4	MLH1	6	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Wang Y (2000), Matton N (2000), Plotz G (2003), Plotz G (2003), Chen TC (2014)	5
EGLN3	0	BLM	2	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	SFN	1	affinity chromatography technology	Urano T (2002)	1
PMS2	4	PCNA	0	affinity chromatography technology, far western blotting, pull down	Cannavo E (2007), Dzantiev L (2004), Genschel J (2017)	3
PMS2	4	KPNB1	3	affinity chromatography technology	Cannavo E (2007)	1
KPNA4	0	EXO1	3	pull down	Andersen SD (2012)	1
ATM	9	RBBP8	1	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Li S (2000), Li S (2000), Kim ST (1999), Li S (2000)	4
PMS1	3	EXO1	3	affinity chromatography technology	Cannavo E (2007)	1
EGLN3	0	EXO1	3	affinity chromatography technology	Rodriguez J (2016)	1
PCNA	0	EXO1	3	imaging technique, far western blotting	Nielsen FC (2004), Dzantiev L (2004)	2
COMT	2	EXO1	3	affinity chromatography technology	Hein MY (2015)	1
BLM	2	EXO1	3	affinity chromatography technology	Nimonkar AV (2008)	1
MSH2	4	MSH3	4	affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, biochemical, pull down	Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Palombo F (1996), Havugimana PC (2012), Owen BA (2009)	8
YWHAH	0	EXO1	3	two hybrid, pull down	Andersen SD (2012), Andersen SD (2012)	2
EGLN3	0	YWHAE	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
EXO1	3	SENP6	2	affinity chromatography technology, pull down	Bologna S (2015), Bologna S (2015)	2
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
MLH1	6	PCNA	0	far western blotting, pull down	Dzantiev L (2004), Genschel J (2017)	2
UBE2I	0	EXO1	3	enzymatic study	Bologna S (2015)	1
YWHAZ	1	SFN	1	biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	3
MLH1	6	MSH3	4	affinity chromatography technology, two hybrid	Cannavo E (2007), Rolland T (2014)	2
EGLN3	0	YWHAZ	1	affinity chromatography technology	Rodriguez J (2016)	1
EXO1	3	MSH3	4	pull down	Schmutte C (2001)	1
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
PMS1	3	MSH2	4	affinity chromatography technology	Matton N (2000)	1
MLH1	6	ATM	9	biochemical	Wang Y (2000)	1
WDR83	1	EXO1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EXO1	3	PMS2	4	affinity chromatography technology, affinity chromatography technology	Schmutte C (2001), Cannavo E (2007)	2
YWHAQ	0	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
YWHAH	0	KLC3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting	Ichimura T (2002), Ichimura T (2002), Ichimura T (2002), Ichimura T (2002)	4
MLH1	6	PMS2	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, pull down, affinity chromatography technology	Mac Partlin M (2003), Mac Partlin M (2003), Kondo E (2001), Kondo E (2001), Kondo E (2001), Kondo E (2001), Guerrette S (1999), Dherin C (2009), Cannavo E (2007), Cannavo E (2007), Cannavo E (2007), Cannavo E (2007), Xie J (2010), Peng M (2007), Nielsen FC (2004), Matton N (2000), Plotz G (2003), Havugimana PC (2012), Brieger A (2010), Dzantiev L (2004), Jaeger AC (2001), Sacho EJ (2008), Hein MY (2015)	23
KPNB1	3	EXO1	3	pull down	Andersen SD (2012)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
EXO1	3	ATM	9	affinity chromatography technology, pull down	Bolderson E (2010), Bolderson E (2010)	2
YWHAQ	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pozuelo-Rubio M (2010), Huttlin EL (2015), Huttlin EL (2017)	3
EGLN3	0	PCNA	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
PMS2	4	MSH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Matton N (2000), Plotz G (2003)	3
TRIM25	5	PCNA	0	affinity chromatography technology, affinity chromatography technology	Park JM (2014), Park JM (2014)	2
BLM	2	ACTR5	1	genetic interference	Vizeacoumar FJ (2013)	1
DNA2	3	RBBP8	1	affinity chromatography technology, pull down	Hoa NN (2015), Hoa NN (2015)	2
TRIM25	5	YWHAQ	0	affinity chromatography technology	Choudhury NR (2017)	1
PMS2	4	MSH3	4	affinity chromatography technology	Cannavo E (2007)	1
YWHAE	0	KLC3	3	affinity chromatography technology	Gloeckner CJ (2007)	1
MSH2	4	BLM	2	biochemical, affinity chromatography technology	Wang Y (2000), Yang Q (2004)	2
MLH1	6	BLM	2	biochemical, pull down, two hybrid, far western blotting, affinity chromatography technology, far western blotting, two hybrid, affinity chromatography technology, far western blotting, two hybrid, unspecified method, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Langland G (2001), Langland G (2001), Langland G (2001), Langland G (2001), Freire R (2001), Pedrazzi G (2001), Pedrazzi G (2001), Pedrazzi G (2001), Dherin C (2009), Dherin C (2009), Meetei AR (2003), Meetei AR (2003)	13
TRIM25	5	YWHAZ	1	affinity chromatography technology	Choudhury NR (2017)	1
PMS1	3	MLH1	6	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Kondo E (2001), Cannavo E (2007), Cannavo E (2007), Mastrocola AS (2010), Matton N (2000), Hein MY (2015)	6
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	YWHAB	1	affinity chromatography technology	Choudhury NR (2017)	1
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
TRIM25	5	YWHAE	0	affinity chromatography technology	Choudhury NR (2017)	1
RBBP8	1	PCNA	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Gu B (2009), Gu B (2009), Gu B (2009), Gu B (2009)	4
EXO1	3	YWHAB	1	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Engels K (2011), Engels K (2011), Andersen SD (2012), Andersen SD (2012), Couzens AL (2013)	5
SFN	1	EXO1	3	two hybrid, pull down	Andersen SD (2012), Andersen SD (2012)	2
KPNA4	0	KPNB1	3	pull down, affinity chromatography technology, affinity chromatography technology	Koehler M (1999), Hein MY (2015), Mukherjee S (2016)	3
YWHAB	1	YWHAH	0	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
MSH3	4	PCNA	0	far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid	Kleczkowska HE (2001), Kleczkowska HE (2001), Clark AB (2000), Ohta S (2002), Ohta S (2002), Rolland T (2014)	6
YWHAZ	1	YWHAH	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	4
ACTR5	1	EXO1	3	affinity chromatography technology	Hein MY (2015)	1
MLH1	6	KPNB1	3	affinity chromatography technology	Cannavo E (2007)	1
EGLN3	0	YWHAQ	0	affinity chromatography technology	Rodriguez J (2016)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
YWHAQ	0	EXO1	3	two hybrid, pull down	Andersen SD (2012), Andersen SD (2012)	2
EXO1	3	YWHAZ	1	two hybrid, affinity chromatography technology, two hybrid, pull down	Engels K (2011), Engels K (2011), Andersen SD (2012), Andersen SD (2012)	4
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
EGLN3	0	KPNB1	3	affinity chromatography technology	Rodriguez J (2016)	1
YWHAG	5	EXO1	3	two hybrid, pull down	Andersen SD (2012), Andersen SD (2012)	2
YWHAG	5	KLC3	3	affinity chromatography technology	Ewing RM (2007)	1
PCNA	0	MSH2	4	affinity chromatography technology, far western blotting	Ohta S (2002), Dzantiev L (2004)	2
EGLN3	0	MSH2	4	affinity chromatography technology	Rodriguez J (2016)	1
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
TRIM25	5	EXO1	3	affinity chromatography technology	Choudhury NR (2017)	1
RBBP8	1	EXO1	3	affinity chromatography technology	Broderick R (2016)	1
CD14	3	EXO1	3	affinity chromatography technology	Hein MY (2015)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
SFN	1	YWHAB	1	affinity chromatography technology	Huttlin EL (2017)	1
ATM	9	BLM	2	biochemical, pull down, affinity chromatography technology	Wang Y (2000), Beamish H (2002), Beamish H (2002)	3
DNA2	3	EXO1	3	genetic interference	Karanja KK (2012)	1
MSH2	4	EXO1	3	two hybrid, pull down, pull down, pull down, pull down	Rasmussen LJ (2000), Schmutte C (1998), Schmutte C (2001), Dherin C (2009), Andersen SD (2012)	5
UBE2I	0	KPNB1	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3