PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AMFR	2	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Morito D (2008), Ballar P (2007), Ye Y (2005), Zhong Y (2011)	4
AMFR	2	ERLIN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jo Y (2011), Jo Y (2011), Jo Y (2011), Pearce MM (2007), Huber MD (2013), Christianson JC (2012)	6
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
UBQLN1	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim PJ (2009), Yu CC (2013), Lim PJ (2009), Lim PJ (2009)	4
AMFR	2	PDIA2	3	affinity chromatography technology	Bernardi KM (2010)	1
DERL1	2	CANX	4	affinity chromatography technology	You H (2017)	1
KCNA3	3	CD3D	0	fluorescent resonance energy transfe	Panyi G (2003)	1
CD3D	0	AMFR	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Chen B (2006)	2
CD3D	0	CANX	4	affinity chromatography technology, imaging technique	van Leeuwen JE (1996), Chen TC (2014)	2
ERLIN2	2	DERL1	2	affinity chromatography technology	Pearce MM (2007)	1
ERLIN2	2	CANX	4	affinity chromatography technology	Jo Y (2011)	1
CD3D	0	CD8A	0	fluorescent resonance energy transfe, affinity chromatography technology	Doucey MA (2003), Doucey MA (2003)	2
VCP	6	CANX	4	affinity chromatography technology, biochemical	Yu CC (2013), Wan C (2015)	2
CD3D	0	PDIA2	3	affinity chromatography technology	Lee SO (2010)	1
ERLIN2	2	CD3D	0	affinity chromatography technology	Pearce MM (2007)	1
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
CD3D	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Zhong X (2004)	2
AMFR	2	CANX	4	affinity chromatography technology	Jo Y (2011)	1
CD3D	0	DERL1	2	affinity chromatography technology	Ballar P (2007)	1
UBQLN1	1	CD3D	0	affinity chromatography technology	Lim PJ (2009)	1