PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HGS	5	LDOC1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
STAM	3	ITCH	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Malik R (2012), Malik R (2012), Malik R (2012), OConnor HF (2015)	4
UBQLN1	1	APP	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Stieren ES (2011), Stieren ES (2011), Hiltunen M (2006)	3
LRIG1	1	ERBB3	3	affinity chromatography technology	Gur G (2004)	1
HGS	5	ITCH	1	affinity chromatography technology, affinity chromatography technology	Marchese A (2003), OConnor HF (2015)	2
TOM1L1	1	HGS	5	two hybrid, two hybrid	Puertollano R (2005), Puertollano R (2005)	2
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
ARRB2	5	HGS	5	affinity chromatography technology, affinity chromatography technology	Han SO (2012), Malik R (2010)	2
HGS	5	STAM2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Rual JF (2005), Bache KG (2003), Bache KG (2003), Mizuno E (2004), Kanazawa C (2003), Kanazawa C (2003), Stuible M (2010), Havugimana PC (2012), Hoeller D (2006), Wan C (2015)	10
TLR4	5	UBQLN1	1	two hybrid	Biswas N (2011)	1
EGFR	5	ARMC8	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Li J (2013)	2
TSG101	1	TOM1L1	1	two hybrid, two hybrid	Puertollano R (2005), Puertollano R (2005)	2
PTPN23	7	TSG101	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007), Kharitidi D (2015)	3
HGS	5	UBQLN1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Regan-Klapisz E (2005)	2
IL2RB	1	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Yamashita Y (2008), Yamashita Y (2008), Amano Y (2011), Amano Y (2011)	4
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
STAM2	0	EPS15	1	affinity chromatography technology	Bache KG (2003)	1
SNX1	2	APP	1	pull down	Olah J (2011)	1
HAP1	1	HGS	5	two hybrid, pull down, affinity chromatography technology	Li Y (2002), Li Y (2002), Li Y (2002)	3
CLTC	12	HGS	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Raiborg C (2001), Raiborg C (2001), Nakamura M (2006), Zlatic SA (2011)	4
HGS	5	SNX5	3	affinity chromatography technology, pull down	Sun Y (2013), Sun Y (2013)	2
SMAD4	9	SMAD5	2	affinity chromatography technology, two hybrid, two hybrid	Hanai J (1999), Haag J (2006), Colland F (2004)	3
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
HGS	5	SNX1	2	pull down, affinity chromatography technology	Chin LS (2001), Popoff V (2009)	2
ERBB3	3	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Verma N (2017), Verma N (2017)	2
NEDD4	2	FGFR2	6	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
PTPN23	7	STAM	3	affinity chromatography technology	Kharitidi D (2015)	1
STAM2	0	VPS37C	3	two hybrid	Rolland T (2014)	1
PMEPA1	1	STAM	3	two hybrid, affinity chromatography technology, pull down	Luo S (2017), Luo S (2017), Luo S (2017)	3
ARRB1	2	STAM	3	affinity chromatography technology, pull down, imaging technique, pull down	Malik R (2010), Malik R (2010), Malik R (2010), Malik R (2010)	4
PELP1	3	TOM1L1	1	two hybrid	Stelzl U (2005)	1
ARRB2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down	Shenoy SK (2008), Bhandari D (2007), Bhandari D (2007)	3
SNX1	2	SNX5	3	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
HGS	5	LRIG1	1	affinity chromatography technology, imaging technique	Oh YM (2014), Oh YM (2014)	2
ARMC8	1	HGS	5	two hybrid, affinity chromatography technology	Tomaru K (2010), Tomaru K (2010)	2
UBQLN1	1	EPS15	1	pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Heir R (2006), Heir R (2006), Regan-Klapisz E (2005), Regan-Klapisz E (2005), NDiaye EN (2008)	5
ARRB1	2	UBC	7	affinity chromatography technology	Xiao K (2007)	1
PTPN23	7	HGS	5	affinity chromatography technology, affinity chromatography technology	Ali N (2013), Kharitidi D (2015)	2
ERBB3	3	HGS	5	affinity chromatography technology, affinity chromatography technology	Fosdahl AM (2017), Fosdahl AM (2017)	2
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
CLTC	12	PTPN23	7	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), St-Denis N (2016)	2
TMEM189	0	UBC	7	pull down	Duex JE (2010)	1
HGS	5	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NF2	1	EGFR	5	affinity chromatography technology, fluorescent resonance energy transfe	Guerrero PA (2015), Ivanov AA (2017)	2
TSG101	1	NEDD4	2	affinity chromatography technology	Medina G (2005)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
STAM	3	UBC	7	pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, unspecified method, pull down, pull down, x-ray crystallography, pull down	Kim MS (2006), Mizuno E (2006), Hong YH (2009), Nathan JA (2013), Nathan JA (2013), Stuible M (2010), Lim J (2011), Baiady N (2016), Kharitidi D (2015), Sundd M (2012), Zhang X (2017)	11
LTBR	0	HGS	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRB2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Han SO (2012)	2
SMAD4	9	HGS	5	affinity chromatography technology, affinity chromatography technology	Miura S (2000), Haag J (2006)	2
SMAD5	2	NEDD4	2	two hybrid	Colland F (2004)	1
EGFR	5	STAM2	0	affinity chromatography technology, pull down	Kong C (2007), Morino C (2004)	2
EGFR	5	ARRB1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
HGS	5	MIF4GD	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PELP1	3	HGS	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Rayala SK (2006), Rayala SK (2006), Rayala SK (2006), Rayala SK (2006)	4
ARRB1	2	NEDD4	2	affinity chromatography technology	Shenoy SK (2008)	1
STAM	3	STAM2	0	imaging technique	Kanazawa C (2003)	1
SCNN1A	1	NEDD4L	3	far western blotting, two hybrid, affinity chromatography technology, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Harvey KF (2001), Malbert-Colas L (2003), Zhou R (2007), Rauh R (2006), Itani OA (2003), Snyder PM (2004), Bhalla V (2006), Lott JS (2002), Ruffieux-Daidie D (2008), Xu D (2015)	10
EGFR	5	ACTN4	4	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
NF2	1	TSG101	1	affinity chromatography technology	Zhou L (2015)	1
IL4R	1	NEDD4L	3	affinity chromatography technology	Warren KJ (2016)	1
UBQLN1	1	STAM2	0	affinity chromatography technology	Regan-Klapisz E (2005)	1
NEDD4L	3	HGS	5	enzymatic study, affinity chromatography technology	Persaud A (2009), Zhou R (2010)	2
TSG101	1	HGS	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, unspecified method, unspecified method, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Rual JF (2005), Lu Q (2003), Lu Q (2003), Lu Q (2003), Kim BY (2007), Im YJ (2010), Schlundt A (2009), Schlundt A (2009), Pornillos O (2003), Pornillos O (2003), Bache KG (2003), Bache KG (2003), Bouamr F (2007), Kim HJ (2007), Kumar B (2016), Kumar B (2016)	16
NEDD4	2	PMEPA1	1	pull down, affinity chromatography technology, enzymatic study, two hybrid	Xu LL (2003), Xu LL (2003), Luo S (2017), Luo S (2017)	4
NEDD4	2	EPS15	1	enzymatic study	Woelk T (2006)	1
CLTC	12	EPS15	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Chi S (2008)	2
SMAD5	2	HGS	5	affinity chromatography technology, two hybrid	Haag J (2006), Haag J (2006)	2
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
SCNN1A	1	ITCH	1	far western blotting	Harvey KF (2001)	1
NEDD4	2	IL2RB	1	affinity chromatography technology	Malarde V (2009)	1
CLTC	12	SNX5	3	two hybrid	Towler MC (2004)	1
IL4R	1	HGS	5	affinity chromatography technology, pull down	Amano Y (2011), Amano Y (2011)	2
SCNN1A	1	HGS	5	affinity chromatography technology, affinity chromatography technology	Zhou R (2010), Zhou R (2010)	2
TOM1L1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Liu NS (2009), Liu NS (2009)	2
EPS15	1	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Woelk T (2006), De Schutter J (2009), Brehme M (2009), Hoeller D (2006), Zhang X (2017), Kristariyanto YA (2017)	6
DAZAP2	1	VPS37C	3	two hybrid	Rolland T (2014)	1
FGFR2	6	APP	1	pull down	Olah J (2011)	1
ARRB2	5	UBC	7	affinity chromatography technology, fluorescent resonance energy transfe	Xiao K (2007), Dalrymple MB (2011)	2
UBC	7	VPS37C	3	pull down	Nathan JA (2013)	1
FGFR2	6	HGS	5	affinity chromatography technology, imaging technique	Belleudi F (2009), Belleudi F (2009)	2
EGFR	5	TSG101	1	affinity chromatography technology	Yao Z (2017)	1
UBC	7	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
STAM	3	HGS	5	two hybrid, affinity chromatography technology, biochemical, pull down, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Asao H (1997), Bache KG (2003), Malik R (2010), Kanazawa C (2003), Kanazawa C (2003), Havugimana PC (2012), Sirisaengtaksin N (2014), Sirisaengtaksin N (2014), Holleman J (2014), Holleman J (2014), Wan C (2015), Berlin I (2010), Huttlin EL (2017)	14
LRIG1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Laederich MB (2004), Gur G (2004), Stutz MA (2008)	3
EPS15	1	HGS	5	pull down, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Bean AJ (2000), Bean AJ (2000), Bache KG (2003), Roxrud I (2008), Roxrud I (2008), Yan Q (2005), Gschweitl M (2016)	7
DLG4	11	HGS	5	two hybrid, affinity chromatography technology	Chetkovich DM (2002), Chetkovich DM (2002)	2
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
HGS	5	ACTN4	4	two hybrid, affinity chromatography technology, biochemical, imaging technique	Yan Q (2005), Yan Q (2005), Kristensen AR (2012), Veettil MV (2016)	4
ERBB3	3	NEDD4	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Huang Z (2014), Huang Z (2014), Huang Z (2014), Verma N (2017)	4
TOM1L1	1	CLTC	12	affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Katoh Y (2006), Liu NS (2009), Collin G (2007), Collin G (2007), Collin G (2007), Collin G (2007), Collin G (2007), Collin G (2007)	8
HGS	5	NF2	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Gutmann DH (2001), Scoles DR (2000), Scoles DR (2000), Scoles DR (2000), Scoles DR (2000), Sun CX (2002), Scoles DR (2002)	7
DAZAP2	1	STAM2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
HGS	5	TMEM189	0	fluorescent resonance energy transfe, affinity chromatography technology	Duex JE (2010), Duex JE (2010)	2
VPS37C	3	APP	1	pull down	Olah J (2011)	1
STAM2	0	UBC	7	x-ray crystallography, x-ray crystallography, pull down, pull down, pull down, pull down, pull down	Lange A (2010), Lange A (2012), Lange A (2012), Stuible M (2010), Baiady N (2016), Zhang X (2017), Hologne M (2016)	7
UBC	7	PTPN23	7	pull down	Kharitidi D (2015)	1
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
PTPN23	7	EGFR	5	affinity chromatography technology	Ali N (2013)	1
STAM2	0	PTPN23	7	affinity chromatography technology, affinity chromatography technology	Ali N (2013), Ali N (2013)	2
SCNN1A	1	TSG101	1	two hybrid	Malbert-Colas L (2003)	1
HGS	5	UBC	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Mizuno E (2006), Raiborg C (2002), Raiborg C (2002), Nathan JA (2013), Nathan JA (2013), Bishop N (2002), Stuible M (2010), Oved S (2006), Hoeller D (2006), Kharitidi D (2015), Zhang X (2017)	11
SCNN1A	1	NEDD4	2	pull down, pull down, far western blotting, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down	Farr TJ (2000), McDonald FJ (2002), Harvey KF (2001), Snyder PM (2001), Bobby R (2013), Panwalkar V (2016), Panwalkar V (2016)	7
ARRB1	2	HGS	5	affinity chromatography technology, affinity chromatography technology	Malik R (2010), Han SO (2012)	2
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
STAM2	0	TSG101	1	biochemical	Wan C (2015)	1
LYST	8	HGS	5	two hybrid, pull down	Tchernev VT (2002), Tchernev VT (2002)	2
DAZAP2	1	NEDD4L	3	two hybrid	Rolland T (2014)	1
UBC	7	TOM1L1	1	pull down	Katoh Y (2004)	1
CLTC	12	STAM	3	affinity chromatography technology, pull down	Nakamura M (2006), McCullough J (2006)	2
HGS	5	EXOC7	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TLR4	5	HGS	5	affinity chromatography technology, affinity chromatography technology	Husebye H (2006), Husebye H (2006)	2
ARRB1	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Bhandari D (2007)	2
SNX1	2	EGFR	5	affinity chromatography technology	Haft CR (1998)	1
STAM	3	SNX1	2	affinity chromatography technology	Huttlin EL (2017)	1
TRAK1	7	HGS	5	imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Webber E (2008), Webber E (2008), Webber E (2008), Webber E (2008)	4
EGFR	5	EXOC7	3	affinity chromatography technology	Foerster S (2013)	1
CLTC	12	ARRB2	5	pull down	Goodman OB (1997)	1
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
VPS37C	3	HGS	5	two hybrid, two hybrid	Eastman SW (2005), Rolland T (2014)	2
PMEPA1	1	HGS	5	two hybrid, affinity chromatography technology, pull down	Luo S (2017), Luo S (2017), Luo S (2017)	3
ARRB1	2	CLTC	12	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Xiao K (2007), McLaughlin NJ (2006), McLaughlin NJ (2006), Goodman OB (1997)	4
TSG101	1	VPS37C	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical	Eastman SW (2005), Eastman SW (2005), Stefani F (2011), Stefani F (2011), Wunderley L (2014), Rolland T (2014), Wan C (2015)	7
STAM2	0	ITCH	1	pull down, pull down	Malik R (2012), Malik R (2012)	2
EPS15	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	van Delft S (1997), Sigismund S (2005), Bertelsen V (2011), Parachoniak CA (2009), Parachoniak CA (2009), Hoeller D (2006)	6
TSG101	1	ACTN4	4	biochemical	Wan C (2015)	1