PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CD2	2	CD58	1	x-ray crystallography, pull down	Kim M (2001), Ramani SR (2012)	2
PTPRC	1	LCK	0	affinity chromatography technology, pull down, affinity chromatography technology	Koretzky GA (1993), Ng DH (1996), Jury EC (2004)	3
UBC	7	LCK	0	unspecified method, x-ray crystallography	Kang J (2008), Kang J (2008)	2
CD2	2	LGALS1	1	affinity chromatography technology	Walzel H (2000)	1
CD2	2	FYN	1	pull down	Lin H (1998)	1
CD2	2	PTPRC	1	pull down	Schraven B (1990)	1
CD2	2	CD53	2	affinity chromatography technology	Bell GM (1992)	1
CD2	2	LCK	0	affinity chromatography technology, pull down	Bell GM (1996), Bell GM (1996)	2
CD2	2	CD2BP2	0	two hybrid, pull down, affinity chromatography technology, pull down	Nishizawa K (1998), Nishizawa K (1998), Nishizawa K (1998), Kofler M (2005)	4
CD2	2	CD2AP	0	pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down	Hutchings NJ (2003), Moncalian G (2006), Tibaldi EV (2003), Ceregido MA (2013), Ceregido MA (2013), Ceregido MA (2013)	6
LGALS1	1	PTPRC	1	affinity chromatography technology	Pace KE (1999)	1
CD2	2	CD5	1	affinity chromatography technology	Carmo AM (1999)	1
CD48	1	LCK	0	affinity chromatography technology	Hawash IY (2002)	1
CD2	2	ITK	7	affinity chromatography technology	Lin H (1998)	1
CD5	1	LCK	0	affinity chromatography technology	Bamberger M (2011)	1
LCK	0	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
UBC	7	SH3KBP1	1	pull down, x-ray crystallography, pull down, x-ray crystallography, pull down, x-ray crystallography	Bezsonova I (2008), Korzhnev DM (2009), Ortega Roldan JL (2013), Ortega Roldan JL (2013), Stamenova SD (2007), Bezsonova I (2008)	6
ITK	7	FYN	1	pull down, pull down	Bunnell SC (2000), Bunnell SC (1996)	2
CD2	2	197196	0	two hybrid	Wang J (2011)	1
CD2	2	LYAR	0	two hybrid	Wang J (2011)	1
SH3KBP1	1	CD2AP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tossidou I (2010), Gaidos G (2007), Huttlin EL (2017)	3
FYN	1	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
CD2	2	CD48	1	pull down	Zhu B (2002)	1
UBC	7	CD2AP	0	pull down, x-ray crystallography	Ortega Roldan JL (2013), Ortega Roldan JL (2013)	2
CD5	1	FYN	1	affinity chromatography technology	Bamberger M (2011)	1
CD2	2	SH3KBP1	1	pull down, two hybrid, affinity chromatography technology, x-ray crystallography, pull down, pull down	Hutchings NJ (2003), Tibaldi EV (2003), Tibaldi EV (2003), Ceregido MA (2013), Ceregido MA (2013), Ceregido MA (2013)	6
UBC	7	CD2	2	pull down	Nathan JA (2013)	1
CD2	2	PSTPIP1	3	two hybrid, pull down	Li J (1998), Li J (1998)	2