PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDKN1A	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Ono T (2000), McKenzie PP (2003), McKenzie PP (2003), Law BK (2002), Harper JW (1993), Harper JW (1993), Yam CH (1999), Selma Dagtas A (2010), Naderi S (2005), Varshochi R (2005), Jeong JH (2010), Hsu SP (2008), Scholz A (2003), Peiretti A (2003), Peiretti A (2003), Derjuga A (2001), Kim YB (2000), Park US (2000), Kim WH (2000), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bendjennat M (2003), Zheleva DI (2002), Mandal M (1998), Bao GC (2006), Mattock H (2001), Chen Z (2002), Chen J (1996), Chen J (1996), Levkau B (1998), Levkau B (1998), Ramachandran N (2004), Lacy ER (2005), Akagi M (1996), Zhao J (1998), Zhang Y (1999), Poon RY (1998), Gorospe M (1996), Varjosalo M (2013), Varjosalo M (2013), Fogeron ML (2013), Huttlin EL (2015), Hall JR (2014), Hein MY (2015), Hein MY (2015), Chen TC (2014), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	51
VAPA	1	VAPB	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishimura Y (1999), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
GMPPB	2	CCNB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCNB2	3	TSPYL2	4	affinity chromatography technology	Li Y (2008)	1
PAXIP1	1	CIRBP	1	affinity chromatography technology	Woods NT (2012)	1
CKS2	0	PKMYT1	1	affinity chromatography technology	Huttlin EL (2017)	1
CCNB1	3	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Di Fiore B (2010), Nishiyama A (2000), Wolthuis R (2008), Desai D (1995), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
CDC25C	0	CDK1	0	pull down, affinity chromatography technology	Morris MC (2000), St-Denis N (2016)	2
DDX3Y	0	CCNB2	3	biochemical	Wan C (2015)	1
CCDC14	2	CCNB2	3	bioid	Firat-Karalar EN (2014)	1
CKS1B	0	CCNB2	3	pull down, affinity chromatography technology	Radulovic M (2010), Huttlin EL (2017)	2
CDK7	0	CDK2	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Drapkin R (1996), Cheng A (2005), Xu X (1999), Higashi H (1996), Aprelikova O (1995), Moisan A (2004), Larochelle S (2012), Larochelle S (2006), Larochelle S (2006), Garrett S (2001), Garrett S (2001), Lolli G (2004), Varjosalo M (2013), So J (2015)	14
CDKN1A	1	CKS2	0	affinity chromatography technology	Fogeron ML (2013)	1
PCM1	5	DIAPH3	7	bioid	Gupta GD (2015)	1
CCNB1	3	CKS2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Radulovic M (2010), Hein MY (2015), Huttlin EL (2017)	4
CDK1	0	CCNB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
CCNB1	3	CDKN1A	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Amador V (2007), Garcia-Wilson E (2005), Ando T (2001), Poon RY (1996), Fogeron ML (2013), Chen TC (2014)	6
CDH1	4	VAPA	1	bioid	Guo Z (2014)	1
GHITM	1	CCNB2	3	affinity chromatography technology	Huttlin EL (2017)	1
CCNB1	3	HNRNPLL	1	biochemical	Wan C (2015)	1
CCNB2	3	CDK7	0	biochemical	Wan C (2015)	1
SCAF4	9	VAPB	2	biochemical	Havugimana PC (2012)	1
CKS2	0	CCNB2	3	pull down, affinity chromatography technology	Radulovic M (2010), Huttlin EL (2017)	2
NIN	4	CCNB2	3	bioid	Gupta GD (2015)	1
CEP128	1	CCNB2	3	bioid	Gupta GD (2015)	1
CCNB1	3	DIAPH3	7	biochemical	Wan C (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CDK1	0	PKMYT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	4
XPO1	8	PAXIP1	1	affinity chromatography technology	Kirli K (2015)	1
CDC25C	0	CCNB1	3	pull down	Morris MC (2000)	1
XPO1	8	DIAPH3	7	affinity chromatography technology	Kirli K (2015)	1
CEP128	1	CCNB1	3	bioid	Gupta GD (2015)	1
TGFBR2	0	CCNB1	3	pull down	Liu JH (1999)	1
CCNB1	3	CCNB2	3	biochemical	Wan C (2015)	1
FAM234B	0	CCNB2	3	affinity chromatography technology	Huttlin EL (2017)	1
NIN	4	PCM1	5	bioid	Gupta GD (2015)	1
CCNB1	3	TSPYL2	4	affinity chromatography technology, pull down	Li Y (2008), Li Y (2008)	2
CDH1	4	VAPB	2	bioid	Guo Z (2014)	1
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
CDKN1A	1	CKS1B	0	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Huttlin EL (2017)	2
CDH1	4	DIAPH3	7	bioid	Guo Z (2014)	1
ATR	6	MCM2	3	enzymatic study	Cortez D (2004)	1
CCNB1	3	CDK7	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Garrett S (2001), Huttlin EL (2015), Huttlin EL (2017)	3
HNRNPLL	1	CCNB2	3	biochemical	Wan C (2015)	1
CCNB2	3	PDS5A	5	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	CCNB2	3	bioid	Guo Z (2014)	1
CCNB2	3	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ramachandran N (2004), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
CDK1	0	CKS1B	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Havugimana PC (2012), Hixon ML (1998), Varjosalo M (2013), Radulovic M (2010), Rolland T (2014), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	11
CCNB2	3	KRT73	1	affinity chromatography technology	Hein MY (2015)	1
WDFY1	0	CCNB2	3	affinity chromatography technology	Huttlin EL (2017)	1
CDC25C	0	CCNB2	3	affinity chromatography technology	St-Denis N (2016)	1
PAXIP1	1	HNRNPLL	1	two hybrid	Woods NT (2012)	1
CDK1	0	CKS2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Varjosalo M (2013), Radulovic M (2010), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
CCNB2	3	PKMYT1	1	affinity chromatography technology	Hein MY (2015)	1
CKS1B	0	CKS2	0	affinity chromatography technology	Huttlin EL (2017)	1
PCM1	5	CCDC14	2	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CCNB2	3	DIAPH3	7	biochemical	Wan C (2015)	1
CCNB1	3	PKMYT1	1	affinity chromatography technology	Hein MY (2015)	1
CCNB2	3	CDKN1A	1	pull down	Ramachandran N (2004)	1
CDK2	0	TSPYL2	4	enzymatic study	Chai Z (2001)	1
PCM1	5	CCNB1	3	bioid	Gupta GD (2015)	1
ATR	6	CCNB2	3	biochemical	Havugimana PC (2012)	1
XPO1	8	CCNB1	3	affinity chromatography technology	Kirli K (2015)	1
CRHBP	2	CCNB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCNB2	3	PAXIP1	1	affinity chromatography technology	Hein MY (2015)	1
CDK1	0	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amador V (2007), Ando T (2001), Lin ML (2011), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
NIN	4	CCNB1	3	bioid	Gupta GD (2015)	1
XPO1	8	CCNB2	3	affinity chromatography technology	Kirli K (2015)	1
CCNB2	3	TGFBR2	0	pull down, pull down	Liu JH (1999), Liu JH (1999)	2
CIRBP	1	CCNB2	3	biochemical	Wan C (2015)	1
CDK2	0	CKS1B	0	x-ray crystallography, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bourne Y (1996), Xu S (2007), Yao ZP (2006), Seeliger MA (2005), Varjosalo M (2013), Radulovic M (2010), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	12
MCM2	3	XPO1	8	affinity chromatography technology	Drissi R (2015)	1
VAPA	1	CCNB2	3	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	VAPA	1	affinity chromatography technology	Drissi R (2015)	1
CKS1B	0	PKMYT1	1	affinity chromatography technology	Huttlin EL (2017)	1
CDK1	0	CDK7	0	enzymatic study	Garrett S (2001)	1
CCNB1	3	RNASEH2C	0	biochemical	Wan C (2015)	1
PCM1	5	CCNB2	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CCNB1	3	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Yang Q (2000), Pines J (1989), Kong M (2000), Amador V (2007), Paulsen MT (2006), Niida H (2005), Pereg Y (2010), Tamura D (2010), Kiviharju-af Haellstroem TM (2007), Pan ZQ (1993), Pan ZQ (1993), Pan ZQ (1993), van Zon W (2010), Desai D (1995), Vazquez-Novelle MD (2010), Smith EM (2008), Poon RY (1996), OConnor PM (1993), Fosbrink M (2009), Linares JF (2011), Varjosalo M (2013), Felzien LK (1998), Toby GG (2003), So J (2015), Huttlin EL (2015), Wan C (2015), Jenkins RH (2014), Hein MY (2015), Hein MY (2015), Voets E (2015), Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	34
CCNB2	3	MCM2	3	pull down	Ramachandran N (2004)	1
CEP128	1	CCDC14	2	bioid	Gupta GD (2015)	1
NIN	4	DIAPH3	7	bioid	Gupta GD (2015)	1
CCNB2	3	RNASEH2C	0	biochemical	Wan C (2015)	1
CDK2	0	CDC25C	0	enzymatic study, enzymatic study	Cheng A (2005), Sebastian B (1993)	2
CKS2	0	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Radulovic M (2010), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
VAPB	2	CCNB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC14	2	CDK1	0	bioid	Firat-Karalar EN (2014)	1
CEP128	1	NIN	4	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CDK1	0	TSPYL2	4	enzymatic study	Chai Z (2001)	1
MCM2	3	DDX3Y	0	affinity chromatography technology	Drissi R (2015)	1
CCNB2	3	SCAF4	9	affinity chromatography technology	Hein MY (2015)	1
CCNB1	3	CKS1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Hein MY (2015), Huttlin EL (2017)	3